What is NMN? Effects, effects, side effects [supplements].

What if we stopped growing old? Eternal youth is a desire as old as humanity. Have we just discovered the holy grail of longevity?

Nicotinamide mononucleotide, available in dietary supplements under the much easier-to-remember name NMN, is supposed to be the cure for all the evils of the passing years. However, for the time being, studies confirming its efficacy in humans are also... scarce.

See also:

• NAC (N-acetylcysteine)
.
• Alpha-lipoic acid
• Vitamin B3 (niacin)
• B vitamins
• Vitamin A
.
• Vitamin C
• Vitamin D3
• Vitamin E
• Vitamin K
• Vitamin K2
• ADEK vitamins

What is NMN?

NMN (nicotinamide mononucleotide) is a naturally occurring chemical compound - a nucleotide - in the body. It is a product of the metabolism of vitamin B3 and a precursor of NAD+ (nicotinamide adenine dinucleotide). This means that after oral administration, NMN is eventually converted to NAD+. Thus, it affects the concentration of NAD+ in the bodyand.

Why is NAD+ important?

NAD+ is also a nucleotide found in the body. It is involved in cellular respiration and converting what you eat into metabolic energy. In addition, it stimulates enzymes that are responsible for repairing damage in DNA chainsand.

Furthermore, NAD+ is a chemical compound that is involved in many cellular processes in the body. For example, it is essential for the proper functioning of mitochondriaand.

Simply put, NAD+ slows down the body's ageing process, because it makes your cells work more efficiently and are repaired more effectively. However, the concentration of NAD+ in the body decreases with ageand.

How to increase the concentration of NAD+ in the body?

One way to increase the concentration of NAD+ in the body is to take its precursor, NMN. Nicotinamide mononucleotide has high bioavailability, meaning it is easily absorbed into the bodyand.

Pure composition

YANGO NMN precursor NAD+

5.0

• NMN content: 500 mg
.
• Additional active ingredients: none
.
• Form: capsules
.
• Dose: 1 capsule per day
.
• Sufficient for: 60 days
.

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in the Natu.Care shop

Product description

The dietary supplement Yango NMN (Nicotinamide Mononucleotide) is a high-quality product containing β-nicotinamide mononucleotide, a key chemical in energy production in the cellsór. It is a precursor of NAD+, an important coenzyme in metabolic processes, intracellularórk communication and DNA repair. 

Supplementation with NMN may support normal energy metabolism and help prevent ageing. The filler-free product, encapsulated in a vegan capsule, guarantees the highest quality and safety.

Supplementation of NMN can help to support energy metabolism.

Pros and cons

The dietary supplement Yango NMN (Nicotinamide Mononucleotide) is a high-quality product containing β-nicotinamide mononucleotide, a key chemical in energy production in the cellsór. It is a precursor of NAD+, an important coenzyme in metabolic processes, intracellularórk communication and DNA repair. 

Supplementation with NMN may support normal energy metabolism and help prevent ageing. The filler-free product, encapsulated in a vegan capsule, guarantees the highest quality and safety.

Supplementation of NMN can help to support energy metabolism.

Additional information

The dietary supplement Yango NMN (Nicotinamide Mononucleotide) is a high-quality product containing β-nicotinamide mononucleotide, a key chemical in energy production in the cellsór. It is a precursor of NAD+, an important coenzyme in metabolic processes, intracellularórk communication and DNA repair. 

Supplementation with NMN may support normal energy metabolism and help prevent ageing. The filler-free product, encapsulated in a vegan capsule, guarantees the highest quality and safety.

Supplementation of NMN can help to support energy metabolism.

Nicotinamide mononucleotide can also be synthesised in the body. This happens when enzymes using NAD+ produce nicotinamide, which is then converted to NMN as a spare substance in the rescue pathway, adds pharmacist.

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.
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Properties of NMN

NMN is credited with many health-promoting properties. As a precursor to NAD+, it is thought to have anti-ageing effects, increase performance and regulate metabolism. In addition, some scientists see it as having therapeutic potential for lifestyle and age-related diseases such as diabetes, Alzheimer's disease and cardiovascular conditionsand.

Unfortunately, there are currently few human studies that can unequivocally confirm the beneficial properties of NMN. Most of the scientific work on this compound is preclinical research, conducted on mice, pigs and even insects .

Based on this, it is difficult to say how NMN actually affects humans. Most of the study results seem optimistic, but there is also no shortage of studies that suggest that taking NMN had no significant effect on the human bodyand.

How does NMN work?

NMN is credited with preventing cellular ageing, protecting chromosomes or regenerating DNA damage. The compound can also support the proper functioning of mitochondria, which are the energy centre of cells. NMN supplementation may also support the maintenance of normal insulin balance and regulate metabolismand.

Aging at the cellular level can be defined as a decrease in energy production in cells. And it is these cells that make up our entire body, including our internal organs. Consequently, when cells stop working efficiently, the functioning of the entire body deteriorates.

Aging at the cellular level can be defined as a decline in energy production.

Maintaining an adequate concentration of NAD+ is supposed to ensure that cells produce energy more efficiently and function optimally. In practice, this means slowing down the ageing of the body. NMN supplementation is supposed to help ensure proper NAD+ levelsand.

NMN and NAD+ deficiency

Magister of Pharmacy Ilona Krzak explains further: depletion of NAD+ can occur in response to excessive DNA damage from free radical attack or ultraviolet radiation. Thus, people who spend long periods of time in the sun without UV filters should increase their intake of nicotinamide mononucleotide.

NMN deficiency may also be indirectly caused by an excess supply of lecithin, which inhibits the formation of niacin.

Effects of NMN supplementation

NMN, as a precursor to NAD+, can regulate metabolism and inhibit the body's ageing processes. Most studies confirm that NMN increases NAD+ levels in blood cells, which is important for energy production, metabolic regulation and overall health. It is also possible that NMN supplementation may help prevent heart disease or neurodegenerative conditionsand.

NMN and performance and fitness

Taking NMN may benefit respiratory capacity, as well as muscle strength and endurance.

A study conducted on 48 amateur runners showed that NMN supplementation for six weeks increased the aerobic capacity of those included in the experiment. However, it is worth noting that, along with taking NMN, the subjects exercised 5-6 times a weekand.

In contrast, a study conducted on a group of older, healthy men suggested that NMN supplementation improved gait speed and grip strength, and therefore muscle performance and strength. At the same time, the researchers did not observe an increase in muscle mass in the subjectsand.

This NMN seems great, huh? Possibly, but I'm tossing you another study. In 2019, researchers showed that aerobic and resistance training (without any additional supplementation) also stops the decline of NAD+ in skeletal muscleand. Ot, movement is health.

NMN and diabetes prevention

Maintaining adequate insulin sensitivity in the body's cells is key to preventing diseases such as type 2 diabetes and insulin resistance. It can also support normal metabolism.

A study conducted on people aged 40-65 years suggests a beneficial effect of NMN supplementation on cellular insulin sensitivityand. This effect is also supported by positive insulin sensitivity findings in postmenopausal pre-diabetic women .

NMN and cardiovascular disease

Researchers attribute NMN supplementation's potentially beneficial effect on the prevention of cardiovascular disease, as metabolic disorders are the cause of many of them.

However, a 12-week study, during which 36 middle-aged people supplemented with NMN, showed no changes in blood parameters, hormones or biochemical testsand. 

The researchers also tested the effect of NMN on pulse waves, an indicator used to test arterial stiffness. Arterial stiffness is one of the risk factors for developing cardiovascular diseaseand.

Interestingly, in people with normal body mass index and blood glucose levels, taking NMN did not result in significant changes. However, in a group of people with an elevated body mass index and high blood glucose levels - i.e. those at risk of hypertension - NMN resulted in a lower pulse waveand.

Is this enough to consider NMN as a remedy for cardiovascular disease? Certainly not. Despite some promising animal studies and the human study cited above, further studies are needed, taking into account a larger group of subjects.

Other

There are still several unpleasant effects associated with the ageing process. These include, for example, problems getting pregnant. Preliminary animal studies suggest that NMN supplementation, and consequently increased NAD+ concentrations, may counteract the deterioration of female germ cells (oocytes)and.

Another problem that occurs with age is insomnia. Research is currently underway into the effect of taking NMNs on improving sleep physiology .

NAD+ plays an important role in intestinal homeostasis, and supplementation with NMN, one of the precursors of NAD+, increases its biosynthesis in the gut. These precursors exhibit anti-inflammatory effects, which positively affects people with intestinal mucositis, explains pharmacist.

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.
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Dosing of NMN

One thing the research results seem to agree on is that NMN supplementation is safeand. So you can verify for yourself the claims made by scientists and see if taking NMN will benefit your wellbeing and health.

What daily dose of NMN would be appropriate? When studying the effects of NMN supplementation on the human body, participants were most often given doses ranging from 150 mg to as much as 900 mg of NMN. However, the most common daily portions of this ingredient are about 300-500 mgand.

In the 2023 study, participants were divided into three groups given 300 mg, 600 mg and 900 mg of nicotinamide mononucleotide daily, respectively. The group taking 600 mg per day of NMN showed better supplementation effects than the group consuming 300 mg, but the differences between the group taking 600 mg and 900 mg were no longer as significantand.

Taking this into account, taking a daily dose of NMN above 600 mg does not seem necessary.

Foods with NMN

Most nutrients such as vitamins and minerals are best supplemented with a healthy and balanced diet. But it won't be so easy with NMN because it's scarce in food. Well, because, can you manage to eat about 50 kg of avocado or broccoli to provide yourself 500 mg of NMN?

Does NMN have side effects?

In the majority of studies, no side effects of taking NMN were observed, so its supplementation is considered safe. The exception is a 2021 scientific paper in which some participants taking 250 mg NMN daily for 12 weeks experienced mild gastrointestinal and upper respiratory complaintsand.

NMN - expert opinions

"NMN is new to the world of supplements. Although most of the studies are no more than 5 years old, I personally use it among clinical patients, especially those with predominantly cardiovascular diseases. Especially as it is not uncommon for them to additionally have diabetes and be elderly with limited physical activity. 

The niacin metabolite, or NMN component, is such an 'energy distribution booster in the body', for the reason that its action mainly focuses on the mitochondria. NMN is a cofactor of mitochondrial processes, and is responsible for genomic stability, DNA production and cell repair. 

"Studies show promising results regarding the safety of taking NMN.

Our population is ageing and every year we have more patients with metabolic syndrome, vascular disease or heart conditions.

The cardioprotective effects and improvement of glucose metabolism and insulin sensitivity outweigh the minor side effects of supplementation. 

It has been suggested that NMN may be effective in reducing the risk of Alzheimer's disease, which is very important as it is estimated that more and more people will face this condition over time. So we need effective measures to guard against it.

See also:

• How to take care of your health
• What are antioxidants
• What is oxidative stress
• NAC (N-acetylcysteine)
.

Summary