Melatonin: effects, dosage and contraindications

Melatonin - everything you need to know about the darkness hormone.

Nina Wawryszuk - AuthorAuthorNina Wawryszuk
Nina Wawryszuk - Author
AuthorNina Wawryszuk
Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Learn more about our editorial process

.
Witold Tomaszewski - Reviewed byReviewed byWitold Tomaszewski
Verified by an expert
Witold Tomaszewski - Reviewed by
Reviewed byWitold Tomaszewski
Doctor of Medicine

Doctor of Medicine, food and pharmaceutical law expert and experienced medical professional.

Learn more about our editorial process

.
Michael Tomaszewski - Edited byEdited byMichael Tomaszewski
Michael Tomaszewski - Edited by
Edited by
Michael Tomaszewski
Editor

Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

Learn more about our editorial process

.
Ludwig Jelonek - Fact-checkingFact-checkingLudwig Jelonek
Ludwig Jelonek - Fact-checking
Fact-checkingLudwig Jelonek
Natu.Care Editor

Ludwik Jelonek is the author of more than 2,500 texts published on leading portals. His content has found its way into services such as Ostrovit and Kobieta Onet. At Natu.Care, Ludwik educates people in the most important area of life - health.

Learn more about our editorial process

.
Melatonin: effects, dosage and contraindications
17 March, 2024
17 min
Why you can trust us

Why you can trust us

Articles on Natu.Care are written based on scientific research, data from government websites and other reliable sources. The texts are written in cooperation with doctors, nutritionists and other health and beauty experts. Articles are reviewed before publication and during significant updates.

.

Learn more about our editorial process

.
Information on advertisements

Information about advertisements

Content on Natu.Care may contain links to products from the sale of which we may receive a commission. When creating content, we adhere to high editorial standards and take care to be objective about the products discussed. The presence of affiliate links is not dictated by our partners, and we select the products we review ourselves completely independently.

.

Learn more about our terms and Conditions

.
Media about us:

They call it the 'Queen of Sleep'. Melatonin, or the darkness hormone. It's what makes you start to yawn in the evening and your eyes close on their own. Unfortunately, sometimes instead of a natural surge of sleepiness there is rolling from side to side, nervously checking the time or waking up frequently.

In this article, you will read how melatonin aids sleep and what other interesting properties it has that you certainly haven't heard about.

.

In this article you will find the following information:

  • Melatonin - what is it and where does it come from?
  • .
  • Melatonin in tablets, drops or maybe with CBD?
  • .
  • Indications for the use of melatonin
  • .
  • Dosing of melatonin
  • .
  • Contraindications to use
  • .
  • Interactions - what not to combine melatonin with
  • .
  • Side effects of taking melatonin
  • .
  • What foods are rich in melatonin
  • .

Editor's choice

Natu.Care Sleep Well

Natu.Care Sleep Well
5.0
  • Active ingredients: melatonin, lemon balm leaf extract, valerian root extract, herb extract See price
    in the Natu.Care shop
Product description

Safe tablets to help you fall asleep and improve the quality of your sleep. They contain only natural ingredients that will calm your body and prepare you for a good night's rest. This way, you will wake up in the morning relaxed and rested.

.

Melatonin is a hormone thatós naturally found in the body. Its secretion is linked to the diurnal rhythm and increases after nightfall. Blue light, which we are exposed to while watching TV, sitting at the computer or browsing on the phone, means that the natural synthesis of melatonin can be disrupted.

.

This is why it is worthwhile to support the process of falling asleep with a supplement with melatonin, whose action has been supplemented with plant extracts, encapsulated in the CALMOMIX® complex. They will help your body to calm down before falling asleep and maintain uninterrupted, healthy sleep.

Pros and cons

Safe tablets to help you fall asleep and improve the quality of your sleep. They contain only natural ingredients that will calm your body and prepare you for a good night's rest. This way, you will wake up in the morning relaxed and rested.

.

Melatonin is a hormone thatós naturally found in the body. Its secretion is linked to the diurnal rhythm and increases after nightfall. Blue light, which we are exposed to while watching TV, sitting at the computer or browsing on the phone, means that the natural synthesis of melatonin can be disrupted.

.

This is why it is worthwhile to support the process of falling asleep with a supplement with melatonin, whose action has been supplemented with plant extracts, encapsulated in the CALMOMIX® complex. They will help your body to calm down before falling asleep and maintain uninterrupted, healthy sleep.

Additional information

Safe tablets to help you fall asleep and improve the quality of your sleep. They contain only natural ingredients that will calm your body and prepare you for a good night's rest. This way, you will wake up in the morning relaxed and rested.

.

Melatonin is a hormone thatós naturally found in the body. Its secretion is linked to the diurnal rhythm and increases after nightfall. Blue light, which we are exposed to while watching TV, sitting at the computer or browsing on the phone, means that the natural synthesis of melatonin can be disrupted.

.

This is why it is worthwhile to support the process of falling asleep with a supplement with melatonin, whose action has been supplemented with plant extracts, encapsulated in the CALMOMIX® complex. They will help your body to calm down before falling asleep and maintain uninterrupted, healthy sleep.

User review

Safe tablets to help you fall asleep and improve the quality of your sleep. They contain only natural ingredients that will calm your body and prepare you for a good night's rest. This way, you will wake up in the morning relaxed and rested.

.

Melatonin is a hormone thatós naturally found in the body. Its secretion is linked to the diurnal rhythm and increases after nightfall. Blue light, which we are exposed to while watching TV, sitting at the computer or browsing on the phone, means that the natural synthesis of melatonin can be disrupted.

.

This is why it is worthwhile to support the process of falling asleep with a supplement with melatonin, whose action has been supplemented with plant extracts, encapsulated in the CALMOMIX® complex. They will help your body to calm down before falling asleep and maintain uninterrupted, healthy sleep.

See also:

.

Melatonin - what is it and where does it come from?

.

Melatonin is a neurohormone produced by the pineal gland (a gland located deep in the brain) in response to darkness. During the day, the pineal gland remains inactive. In the evening, as darkness falls, the light entering our retina begins to fade. The pineal gland switches on and produces melatonin.

.

When the melatonin content in the blood rises, we start to feel sleepy. The highest concentration is recorded between 2.00 and 4.00 at nightand. Melatonin coordinates your biological clock.

.

Properties of melatonin

.

Melatonin is mainly associated with its positive effects on the nervous system and the regulation of the diurnal rhythm of sleep and wakefulness. However, this neurohormone has many more propertiesand:

    .
  • It is an antioxidant and exhibits anti-inflammatory effects.
  • Increases the body's immunity against viral, bacterial and parasitic infections.
  • .
  • Has a positive effect on the digestive system, including supporting the pancreas.
  • .
  • Acts osteogenically, i.e. stimulates the building of bone mass.
  • .
  • Influences the regulation of blood pressure.
  • .
  • Exerts a oncostatic effect, i.e. inhibits tumour growth.
  • .

Melatonin in tablets, drops or perhaps with CBD?

.

In Poland, melatonin is sold in pharmacies as an OTC (over-the-counter) medicine or dietary supplement. It is available in doses ranging from 1 mg to as much as 12 mg. There is a wide range of melatonin forms available to suit your preferences.

Melatonin can be purchased:

.
  • in tablet, capsule form,
  • .
  • in spray,
  • .
  • in drops,
  • .
  • in leaves,
  • .
  • in the form of gels,
  • .
  • inhalation,
  • .
  • in combination with CBD oil,
  • .
  • in combination with other herbal substances e.g. ashwagandha,
  • .

Indications for the use of melatonin

.

The use of melatonin has overwhelming support in the scientific literature, regardless of the reasons for its supplementation. 

Deficiency

.

As we age, melatonin secretion decreasesand. This process begins around the age of 50 until the day-night rhythm almost disappears in people over 65. Older people may then notice a decline in the quality of their sleep or problems falling asleep. Melatonin supplementation supports the maintenance of the diurnal rhythm and supplements its deficiency in older people. A dosage of 0.3 mg to 2 mg taken approximately one hour before bedtimeand.

is recommended.

Sleep disorders

.

More than 50% of Poles suffer from sleep disordersand. These disorders include insomnia, difficulty falling asleep, frequent awakenings and nightmares, among others. Melatonin is often the first choice for people trying to improve their sleep quality. It is safe to use and does not cause addiction, unlike prescription sleep medicationsand.

.
Sleep disorders affect our daily functioning. They can contribute to a worsened sense of wellbeing, problems with appetite and a decrease in productivity. If the problem is short-term, melatonin supplementation can help. However, when sleep difficulties do not go away, it is worth seeing a specialist to regain restful sleep with their help.
.
Malgorzata Kaczmarek.

Malgorzata Kaczmarekpsychotherapist and psychologist

.
.

See also:

.

Shift work

.

People who work shifts run the risk of upsetting their diurnal rhythm. When most people go to bed in the evening, many are just starting their day. There is no evidence to support taking melatonin before the daytime sleep that occurs after the night shiftand. It is possible to support with melatonin, but it is worth consulting your doctor as to which intake regimen will be most effective.

Jet lag

.

This is the name for a syndrome involving sleep disturbances resulting from a sudden change in time zonesand. It mainly affects air travellers. Symptoms of jet lag include: 

.
  • excessive sleepiness, 
  • .
  • insomnia, 
  • .
  • irritability, 
  • .
  • decrease in concentration, 
  • .

Adequate intake of melatonin can alleviate or even eliminate the unpleasant discomforts associated with time zone changes and faster adaptation to the new time zone. 

Melatonin for children

.

Scientific evidence suggests that melatonin should be safe for childrenand. The researchers looked at a small group of children who took melatonin regularly for about three years. The researchers found that none of the children had any negative side effects associated with the supplement.

Taking melatonin is beneficial for children aged 3 to 15 years if they have: AD (atopic dermatitis)and, sleep disorders, neurodevelopmental disorders (e.g. autism, ADHD) , sleep difficulties, frequent awakenings during the night and reduced total sleep time. Such melatonin therapies, however, must be carried out under close medical supervision. 

Blind people

.

Most people who are completely blind exhibit circadian rhythmsand. Unfortunately, some experience cyclical or periodic episodes of poor sleep and dysfunction during the dayand that severely disrupt their social or working lives. Melatonin supplementation supports the regulation of the diurnal cycle of blind people and improves their functioning.

See also articles on health:

.

Dosing of melatonin

.

The dosage of melatonin is usually from 0.5 mg to 3 mg per day. Such doses appear to be safe and effective in action, particularly in problems with diurnal rhythm regulationand. The dose should be selected individually.

Melatonin can be bought in doses as low as 12 mg - just why? There is no scientific justification for this. Interestingly, in clinical trials, a dose of 0.5 mg produced improvements in sleepand. There is no official recommended dose of melatonin for adults. In Poland, the lowest dose available for purchase is 1 mg. 

.

Dosing in sleep disorders

.

For sleep problems, it is recommended to dose between 0.5 mg and 3 mg about one hour before bedtime . In studies carried out people suffering from insomnia responded positively to a dose of 0.3 mg . As you can see, lower doses are not at all less effective than higher doses. Start with the lowest possible and see how your body reacts. Remember the sleep hygiene rules for the best effect.

Dosing to prevent jet lag

.

Melatonin taken close to the usual time for falling asleep at your destination (10pm to midnight), alleviates the effects of jet-lag syndrome. A dose of 0.5 mg to 5 mg is recommended. It is worth noting that, according to studies, doses above 5 mg do not appear to be more effective than doses of 3 mgand.

Dosing for shift workers

.

Till now there is no strong evidence to support taking melatonin before the daytime sleep that occurs after the night shift . For those working such a regime, attention is paid to healthy habits that help the body adapt to changes in circadian rhythms. These include scheduled naps, physical activity and avoiding caffeine six hours before bedtime.

Dosing for children

.

Supplementation for children should be under close medical supervision. If a child has sleep problems, start supplementation with the lowest possible dose -1 mgand. Melatonin should be given to the child about 1 hour before bedtime, remembering to keep the child quiet and limit blue light and other stimulating stimuli (loud music, vigorous play). 

Dosing in case of deficiency

.

Older people who are at risk of melatonin deficiency, are advised to use the lowest possible dose to best mimic the normal physiological circadian rhythm of melatonin. This is 0.5 to 2 mg consumed approximately one hour before bedtimeand.

Higher doses have been shown to carry a greater risk of side effects and, most notably, cause a state of elevated melatonin, resulting in a feeling of sluggishness the following dayand. The dose should be chosen individually, depending on the problem you are experiencing. 

What is the best dose of melatonin for me?

.

Always read the leaflet available in the pack and check what the manufacturer suggests, and if in doubt, advise your doctor or pharmacist. Supplementation is tailored to individual needs. 

Dosing is recommended differently when preventing jet lag and differently when having daily sleep difficulties. Be sure to check for possible interactions with other medications. Remember also that it is very important to take melatonin systematically.

.

See also:

Melatonin overdose

.

Melatonin overdose is difficult to define as there is no official safe dose for alland. Individual reactions to this supplement can vary widely. Symptoms of overdose are most common: headache, nightmares, insomnia, rash, gastritisand.

Is it possible to become addicted to melatonin?

.

No, it is not possible to become addicted to melatonin. There is no scientific evidence that melatonin users develop a tolerance to this supplementand. It does not contain compounds with addictive potential.

Contraindications to the use of melatonin

.

Contraindications to the use of melatonin areand:

    .
  • hypersensitivity to melatonin,
  • .
  • pregnancy,
  • .
  • breastfeeding,
  • .
  • autoimmune diseases (e.g. rheumatoid arthritis),
  • .
  • diseases of the liver, kidney,
  • .

Not sure if you can use melatonin? Consult your doctor or pharmacist

Interactions - what not to combine melatonin with?

.

Melatonin should not be combined withand:

.
    .
  • steroid medicines,
  • .
  • anti-coagulants,
  • .
  • drugs used in the treatment of diabetes,
    • .
    • some antidepressants,
    • .
    • benzodiazepines,
    • .

    Melatonin versus alcohol and other stimulants

    .

    While taking melatonin supplementation, you should not consume alcohol and should refrain from consuming products with nicotineand. These reduce the effect of melatonin and can exacerbate the side effects.

    Side effects of taking melatonin

    .

    Some people may experience some side effects with higher doses and extended-release formulations. 

    The most commonly reported side effects of melatonin use includeand:

    • headache,
    • .
    • sleepiness during the day,
    • .
    • nausea, 
    • .
    • dizziness,
    • .

    Clinical studies indicate that long-term treatment with melatonin causes only mild side effects comparable to placeboand. It is worth noting that, unlike prescription sleep medications, melatonin taken in the evening does not impair our psychomotor performance the following day .

    Does melatonin make you fat?

    .

    You do not get fat from melatonin. However, the quality of sleep does affect body weightand. Sleep disturbances affect hormones - not getting enough sleep can result in increased appetite and the consumption of more kilocalories. Therefore, melatonin is often erroneously attributed to weight gain. 

    Melatonin for coronavirus?

    .

    There is a very interesting study currently underway by US researchers. The researchers are looking at melatonin given to patients with COVID-19 and how the patient's infection is affected by the administration of melatonin with vitamin Cand. The work looks very promising, but we will have to wait a while for official results.

    Scientists are also investigating the prevalence of sleep disorders after COVID-19 infection, a problem that affects almost half of American recovering patientsand!

    What foods are rich in melatonin?

    .

    Although melatonin is naturally produced by our body, we can also obtain it from food. 

    Products rich in melatonin include: 

    .
    • eggs,
    • .
    • fatty fish, e.g. salmon, sardines,
    • .
    • walnuts, almonds, pistachios,
    • .
    • fruits e.g. kiwi, cherries, cranberries, strawberries,
    • .
    • milk, especially malted milk,
    • .
    • rice,
    • .
    • corn,
    • .
    • wheat,
    • .

    Melatonin isn't everything: take care of your sleep hygiene

    .

    Are you looking for information about melatonin because you suffer from a sleep disorder? Would you like to help yourself? It's a good idea to start with sleep hygiene and a proper diet.

    These are the 8 most important principles of sleep hygiene:

    1. Try to develop a routine of going to bed and getting up at the same times.
    2. Try to develop a routine of going to bed and getting up at the same times.
    3. Avoid naps during the day.
    4. Avoid naps during the day.
    5. Care to relax. Difficult conversations, a chilling horror movie screening or physical exertion before bed are not good ideas. Try to calm down, meditate, take a bath.
    6. Take a bath.
    7. Avoid late, heavy-digested dinners and excessive fluids. A laden stomach and full bladder will prevent you from getting enough sleep.
    8. Avoid blue light (TV, smartphone) two hours before bedtime.
    9. .
    10. Consume caffeine a maximum 6 hours before bedand.
    11. .
    12. Remember - alcohol makes it easier to fall asleep, but significantly degrades the quality of sleep!
    13. .
    14. Prepare your bedroom for sleep: air out the room, make sure the temperature is optimal - around 18 °C and look for a comfortable mattress for yourselfand.
    15. .

    See also:

    .

    Summary

    .
    .
    • Melatonin occurs naturally in everyone's body.
    • Melatonin is an essential component of the human body.
    • His deficiency can be supplemented with supplementation and a proper diet.
    • It is safe to take.
    • It is safe to use, does not cause addiction, and rarely has side effects.
    • It is also a good source of energy.
    • It is helpful in the treatment of sleep disorders, helps the blind and shift-workers to regulate their diurnal rhythm, alleviates or prevents jet lag syndrome, supplements deficiencies in the elderly and is used to treat ailments of various origins in children.
    • It is a good supplement for the elderly.
    • Pay attention to the interaction of melatonin with drugs and stimulants so as not to interfere with its absorption and avoid side effects.

    FAQ

    .
    . Is it worth taking melatonin?.

    Yes, it is worth taking melatonin because it is helpful for sleep disorders (e.g. insomnia, problems falling asleep, frequent waking) and regulates the diurnal rhythm (e.g. for jet-lag). Scientific studies suggest that as little as 0.3 mg of melatonin facilitates falling asleep and improves the quality and length of sleep.

    . What should melatonin not be combined with?.

    Melatonin must not be combined with alcohol, sedative drugs, antidepressants (e.g. fluvoxamine), benzodiazepines, oestrogens (e.g. in oral contraception), anticoagulants (e.g. warfarin), antiepileptic drugs, anti-inflammatory drugs (e.g. ibuprofen), glucocorticosteroids.

    . After what time does melatonin start to take effect?.

    The effect of melatonin is observed gradually, usually after 2 weeks of regular consumption. To help you fall asleep, it is recommended to consume melatonin tablets about 30 minutes before going to bed and melatonin drops, leaves and sprays about 15 minutes before bedtime.

    . What is melatonin and how does it work?.

    Melatonin is a neurohormone naturally produced by the pineal gland in response to darkness. Melatonin is responsible for regulating our diurnal rhythm and regulating the day-night cycle. Thanks to it, when darkness falls, we feel sleepy in the evening and prepare our body for sleep.

    . What for sleep instead of melatonin?.

    For sleep disorders or regulation of the circadian rhythm, instead of melatonin, consider dietary supplements or infusions of plants such as valerian, passionflower, valerian, lemon balm, hops, lavender, chamomile. They are well tolerated, safe to use and have a positive effect on sleep.

    . What is melatonin in?.

    Products rich in melatonin include eggs, oily fish (e.g. salmon, sardines), nuts (e.g. walnuts, almonds, pistachios), fruit (e.g. kiwi, cherries, cranberries, strawberries), malted milk, white rice, corn, wheat. It is worth consuming these foods at dinner to support the body's production of melatonin.

    . Does melatonin help with sleep?.

    Yes, according to scientific studies melatonin helps with sleep, by aiding the process of falling asleep, improving sleep quality and reducing the number of awakenings during the night. Melatonin supplementation can be an effective support for moderate sleep problems.

    . Do you get fat from melatonin?.

    No, one does not get fat from melatonin. However, the quality of our sleep does affect weight gain. Sleep disturbance affects our hormonal balance - not getting enough sleep can result in increased appetite and the consumption of more calories. This is why melatonin is often mistakenly attributed to weight gain.

    . What is the best dose of melatonin for me?.

    Supplementation is tailored to individual needs. In research studies, doses of 0.3 mg were effective in supporting sleep in people with sleep disorders. It is quality, not quantity, that counts. Always read the package leaflet and check what the manufacturer suggests, and if in doubt, advise your doctor or pharmacist.

    . Which melatonin is the best?.

    The best melatonin to help with sleep and improve the quality and length of our sleep is, for example, Sleep Well with melatonin 1 mg and the standardised herbal extract complex CALMOMIX, which interestingly complete the formulation. The dietary supplement has good reviews among sleepy users.

    .
    .

    Sources

    .
    . See all.

    Abdulwahab, D. A., El-Missiry, M. A., Shabana, S., Othman, A. I., & Amer, M. E. (2021). Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats. Heliyon, 7(3), e06474. https://doi.org/10.1016/j.heliyon.2021.e06474

    Andersen, L. P. H., Gögenur, I., Rosenberg, J., & Reiter, R. J. (2016). The Safety of Melatonin in Humans. Clinical Drug Investigation, 36(3), 169-175. https://doi.org/10.1007/s40261-015-0368-5

    Baghdasht, M. S. B. (2020). Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients (Clinical trial registration No. NCT04409522). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04409522

    Can You Overdose on Melatonin? (2021, May 13). Sleep Foundation. https://www.sleepfoundation.org/melatonin/melatonin-overdose

    Chang, Y.-S., Lin, M.-H., Lee, J.-H., Lee, P.-L., Dai, Y.-S., Chu, K.-H., Sun, C., Lin, Y.-T., Wang, L.-C., Yu, H.-H., Yang, Y.-H., Chen, C.-A., Wan, K.-S., & Chiang, B.-L. (2016). Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial. JAMA Pediatrics, 170(1), 35-42. https://doi.org/10.1001/jamapediatrics.2015.3092

    Circadin 2 mg Prolonged-release Tablets-Summary of Product Characteristics (SmPC)-(Emc). (n.d.). Retrieved March 16, 2023, from https://www.medicines.org.uk/emc/product/2809/smpc#gref

    Garcia, M. S. (2022). Safety and Efficacy of Drugs Given Off-label for COVID-19 (Clinical trial registration No. NCT05596617). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT05596617

    .

    Grivas, T. B., & Savvidou, O. D. (2007). Melatonin the "light of night" in human biology and adolescent idiopathic scoliosis. Scoliosis, 2(1), 6. https://doi.org/10.1186/1748-7161-2-6

    Hardeland, R. (2012). Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction. The Scientific World Journal, 2012, e640389. https://doi.org/10.1100/2012/640389

    Instituto de Investigación Hospital Universitario La Paz. (2021). Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts. (Clinical trial registration No. NCT04353128). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04353128

    Kimszal, E., & Damme-Ostapowicz, K. V. (2015). JET LAG - sudden onset time shift syndrome. http://www.przeglad.amp.edu.pl/uploads/2015/4/271_4_45_2015.pdf 

    Lancaster General Hospital. (2022). The Effect of Melatonin and Vitamin C on COVID-19 (Clinical trial registration No NCT04530539). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04530539

    Lu, X., Yu, S., Chen, G., Zheng, W., Peng, J., Huang, X., & Chen, L. (2021). Insight into the roles of melatonin in bone tissue and bone-related diseases (Review). International Journal of Molecular Medicine, 47(5), 82. https://doi.org/10.3892/ijmm.2021.4915

    MD, N. Y. (2022). Prognostic Value of Serum Melatonin as a Biomarker for the Determination of Severe COVID-19 Infection in Pregnant Women (Clinical trial registration No. NCT05318144). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT05318144

    MD, R. M. (2021). Selective Estrogen Modulation and Melatonin in Early COVID-19 (Clinical trial registration No. NCT04531748). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04531748

    .

    Melatonin Dosage by Age and Weight. (2021, May 28). Sleep Foundation. https://www.sleepfoundation.org/melatonin/melatonin-dosage-how-much-should-you-take

    Melatonin Interactions Checker. (n.d.). Drugs.Com. Retrieved March 16, 2023, from https://www.drugs.com/drug-interactions/melatonin.html

    Melatonin, M. (2013). The role of melatonin in type 2 diabetes mellitus. Clinical Diabetology, 2(4), Article 4. https://journals.viamedica.pl/clinical_diabetology/article/download/35633/25831 

    Mixing Alcohol & Melatonin: Does Alcohol Affect Melatonin | Learn More. (n.d.). The Recovery Village Drug and Alcohol Rehab. Retrieved March 16, 2023, from https://www.therecoveryvillage.com/alcohol-abuse/alcohol-and-melatonin/

    Pharmamel S.L. (2021). A Phase II, Single-center, Double-blind, Randomized Placebo-controlled Trial to Explore the Efficacy and Safety of Intravenous Melatonin in Patients With COVID-19 Admitted to the Intensive Care Unit (MelCOVID Study) (Clinical trial registration No. NCT04568863). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04568863

    PhD, M. L. D. (2022). A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection (Clinical trial registration No. NCT04474483). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04474483

    Piovezan, R. D. (2020). Adjuvant Therapeutic Effects of Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19 (Clinical trial registration No. NCT04470297). clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT04470297

    Pros and cons of melatonin. (n.d.). Mayo Clinic. Retrieved March 16, 2023, from https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/melatonin-side-effects/faq-20057874

    Quera Salva, M. A., Hartley, S., Léger, D., & Dauvilliers, Y. A. (2017). Non-24-Hour Sleep-Wake Rhythm Disorder in the Totally Blind: Diagnosis and Management. Frontiers in Neurology, 8. https://www.frontiersin.org/articles/10.3389/fneur.2017.00686

    Srinivasan, V., Maestroni, G., Cardinali, D., Esquifino, A., Perumal, S. P., & Miller, S. (2005). Melatonin, immune function and aging. Immunity & Ageing, 2, 17. https://doi.org/10.1186/1742-4933-2-17

    Sumsuzzman, D. Md., Choi, J., Jin, Y., & Hong, Y. (2021). Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials. Neuroscience & Biobehavioral Reviews, 127, 459-473. https://doi.org/10.1016/j.neubiorev.2021.04.034

    Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004). Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index. PLOS Medicine, 1(3), e62. https://doi.org/10.1371/journal.pmed.0010062

    The Best Temperature for Sleep: Advice & Tips. (2020, October 29). Sleep Foundation. https://www.sleepfoundation.org/bedroom-environment/best-temperature-for-sleep

    Tordjman, S., Chokron, S., Delorme, R., Charrier, A., Bellissant, E., Jaafari, N., & Fougerou, C. (n.d.). Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology, 15(3), 434-443. https://pubmed.ncbi.nlm.nih.gov/28503116/ 

    Vural, E. M. S., van Munster, B. C., & de Rooij, S. E. (2014a). Optimal Dosages for Melatonin Supplementation Therapy in Older Adults: A Systematic Review of Current Literature. Drugs & Aging, 31(6), 441-451. https://doi.org/10.1007/s40266-014-0178-0

    Vural, E. M. S., van Munster, B. C., & de Rooij, S. E. (2014b). Optimal Dosages for Melatonin Supplementation Therapy in Older Adults: A Systematic Review of Current Literature. Drugs & Aging, 31(6), 441-451. https://doi.org/10.1007/s40266-014-0178-0

    What Treatments Are Available for Shift Work Disorder? (2021, April 21). Sleep Foundation. https://www.sleepfoundation.org/shift-work-disorder/treatment

    Effect of melatonin on diurnal blood pressure profile in patients with no nocturnal blood pressure reduction. (n.d.). Retrieved March 16, 2023, from https://webcache.googleusercontent.com/search?q=cache:NbIiWA8tVEkJ:https://journals.viamedica.pl/arterial_hypertension/article/download/40901/28101+&cd=11&hl=en&ct=clnk&gl=en

    Yazdi, Z. (2008a). Efficacy and hypnotic effects of melatonin in shift-work nurses: Double-blind, placebo-controlled crossover trial (No. 0). 6(0), Article 0. https://doi.org/10.1186/1740-3391-6-10

    Yazdi, Z. (2008b). Efficacy and hypnotic effects of melatonin in shift-work nurses: Double-blind, placebo-controlled crossover trial (No. 0). 6(0), Article 0. https://doi.org/10.1186/1740-3391-6-10

    Zan, R., Roliński, Z., Kowalski, C., Burmańczuk, A., & Poland, B. (2011). Biological properties of melatonin and its clinical applications in animals. https://www.vetpol.org.pl/dmdocuments/ZW%202011_03%20%2007.pdf 

    Zhdanova, I. V., Wurtman, R. J., Regan, M. M., Taylor, J. A., Shi, J. P., & Leclair, O. U. (2001). Melatonin Treatment for Age-Related Insomnia. The Journal of Clinical Endocrinology & Metabolism, 86(10), 4727-4730. https://doi.org/10.1210/jcem.86.10.7901

    .
    .
Rate the article
0.0
Vote cast
0 opinions, rating: 0.0

Editorials

Meet the team
Nina Wawryszuk - Author

Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Witold Tomaszewski - Reviewed by

Doctor of Medicine

Verified by an expert

Doctor of Medicine, food and pharmaceutical law expert and experienced medical professional.

Michael Tomaszewski - Edited by

Editor

Michael Tomaszewski

Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

Ludwig Jelonek - Fact-checking

Natu.Care Editor

Ludwik Jelonek is the author of more than 2,500 texts published on leading portals. His content has found its way into services such as Ostrovit and Kobieta Onet. At Natu.Care, Ludwik educates people in the most important area of life - health.

Young, beautiful women with good skin condition
Take care of a healthy body

Try Natu.Care's high-quality supplements

See products
Artykuły
Melatonin for sleep - properties, dosage. Does it help?

Sep 14

Melatonin for sleep - properties, dosage. Does it help?

Melatonin is a neurohormone naturally secreted by the body that regulates our day and night cycle.

Melatonin - contraindications to use

Sep 13

Melatonin - contraindications to use

From this article you will learn who should be cautious with melatonin supplementation.

Melatonin - dosage. What is the optimal dose?

Sep 13

Melatonin - dosage. What is the optimal dose?

Melatonin is a neurohormone that regulates the day and night cycle. How to supplement it safely?