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Vitamin B12 deficiency. Causes, symptoms and treatment

Correct levels of vitamin B12 have a positive effect on our entire body. Deficiency can be associated with unpleasant health consequences.

Nina Wawryszuk - AuthorAuthorNina Wawryszuk
Nina Wawryszuk - Author
AuthorNina Wawryszuk
Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Learn more about our editorial process

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Alexandra Cudna-Bartnicka - Reviewed byReviewed byAlexandra Cudna-Bartnicka
Verified by an expert
Alexandra Cudna-Bartnicka - Reviewed by
Reviewed byAlexandra Cudna-Bartnicka
Clinical nutritionist

Clinical nutritionist whose main area of interest is nutrition in diseases and functional disorders of the digestive system.

Learn more about our editorial process

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Michael Tomaszewski - Edited byEdited byMichael Tomaszewski
Michael Tomaszewski - Edited by
Edited by
Michael Tomaszewski
Editor

Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

Learn more about our editorial process

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Nina Wawryszuk - Fact-checkingFact-checkingNina Wawryszuk
Nina Wawryszuk - Fact-checking
Fact-checkingNina Wawryszuk
Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Learn more about our editorial process

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Vitamin B12 deficiency. Causes, symptoms and treatment
29 April, 2024
10 min
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Adequate levels of vitamin B12 have a positive effect on our entire body. Deficiency can be associated with unpleasant health consequences.

Can you recognise how your body calls for vitamin B12 supplementation? Together with nutritionist Aleksandra Cudna, we will introduce you to everything you need to know about B12 deficiency and how to deal with it in a healthy way.

The following is an overview of how to identify B12 deficiency.

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Description of contents:

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  1. What causes vitamin B12 deficiency? Find out the causes
  2. B12 deficiency - symptoms and effects on the body
  3. .
  4. How to find out if I have a vitamin B12 deficiency
  5. .
  6. How to make up a vitamin B12 deficiency
  7. .
  8. Vitamin B12 in the diet - advice from a nutritionist
  9. .
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 See also:

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What causes vitamin B12 deficiency? Find out the causes

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Deficiency can occur when serum concentrations of vitamin B12 become too low to meet the body's requirementsand

Causes of deficiency:

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Diet 

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  • poor and poorly nutritious, 
  • .
  • non-nutritious, monotonous,
  • low nutritional value, 
  • low nutritional value.
  • low in calories,
  • vegetarian or vegetarian food,
    • poor in nutrition,
    • low in calories.
    • vegan or vegetarian,
    • .
    • large amount of alcohol,
    • .

    Disorders of absorption

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    • stomach diseases (e.g. gastritis),
    • .
    • inherited intrinsic factor deficiency (the vitamin has nothing to bind to, so it is not absorbed),
    • .
    • diseases of the small intestine (e.g. Crohn's disease, cancer),
    • .
    • celiac disease,
    • .
    • inherited malabsorption,
    • inherited malabsorption,
    • inherited malabsorption.
    • increased consumption by bacteria (bacterial overgrowth syndrome SIBO),
    • .
    • infection with tapeworms,
    • .

    Medication intake

    .

    Simultaneous use of the following substances impairs absorption of vitamin B12and:

    • drugs that reduce gastric acid secretion,
    • .
    • methformin (antidiabetic drug),
    • methformin (antidiabetic drug).
    • contraception hormonaland,
    • .
    • aminosalicylic acid (antitubercular drug),
    • .
    • colchicine (an anti-inflammatory drug used in the prevention and treatment of gout attacks).

    Are you using any of these substances? Don't worry! Your doctor may decide to change your medication or the time you take it, depending on the problems you are experiencing.

    Age 60+

    .

    In this age group, gastric and assimilationand of this vitamin are often affected. 

    Immune system disorders

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    • Graves-Basedow disease,
    • .
    • Addison-Biermer disease,
    • .
    • lupus,
    • .

    Megaloblastic anaemia

    .

    Developing anaemia from a deficiency of vitamin B12 in the body when it is not properly absorbed from the gastrointestinal tract.

    Post-operative conditions

    .
    • Removal of part/whole stomach,
    • .
    • bariatric surgery, 
    • .
    • removal of ileum,
    • .

    Are you at risk of vitamin B12 deficiency? Check out the symptoms of vitamin B12 deficiency now - sound familiar? Or maybe someone close to you has some of the symptoms?

    .

    B12 deficiency - symptoms and effects on the body

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    Vitamin B12 deficiency manifests itself on the part of many systems in the body and you may experience weakness, dizziness, gastrointestinal disturbances, malaise or characteristic 'clotting', among other things.

    Find out more about vitamin B12 deficiency.

    Find out what to look out for in particular.

    .

    Symptoms of vitamin B12 deficiency:

    .

    Nerve system: 

    .
    • pain and dizziness,
    • .
    • weakness, muscle aches and fatigue,
    • .
    • disorders of the sensory organs, especially touch,
    • .
    • paresthesias (numbness, tingling, burning),
    • .
    • ataxia (reduced coordination of movements and trouble maintaining balance)and.
    • .

    Cardiovascular system:

    .

    Deficiency leads to anemia (anemia) megaloblastic manifesting as:

    • dizziness, 
    • .
    • blindness, 
    • .
    • spiration, 
    • .
    • weakness, 
    • .
    • fast heart rate, 
    • .

    Digestive system: 

    .
    • constipation or diarrhea;
    • loss of appetite.
    • loss of appetite, nausea,
    • .
    • weight loss,
    • .
    • distaste disorder,
    • disorder of taste,
    • disorder of taste.
    • stomatitis with ulceration and inflammationand,
    • .
    • swelling, burning and redness of the tongue, 
    • .

    Psychiatry:

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    • low mood,
    • .
    • mood changes,
    • .
    • symptoms depressive symptomsand,
    • anxiety,
    • .
    • concentration and memory problems;
    • .

    Emergency:

    .
    • disorders of vision.
    .

skin, hair, nails:

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  • yellowish colour skinand,
  • .
  • breakage and hair loss,
  • fracture, splitting and pigmentation changes on nails.

Libido:

  • Erectile dysfunctionand as a result of increased levels of homocysteine in the body.

How to find out if I have a vitamin B12 deficiency?

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Before supplementation, take a look at your diet. Is it varied? Are you eating foods rich in vitamin B12? If you're not sure, and you're experiencing some of the symptoms we write about above - it's best and safest to have your blood B12 levels tested.
Aleksandra Cudna.

Aleksandra Cudna Nutritionist

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You can take the test privately. It is worth buying the whole package of B vitamins at once - the price is cheaper, and you will be examined comprehensively. 

See also:

How to make up for vitamin B12 deficiency?

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I had a patient who came to me with low vitamin B12 levels. The cause was probably long-term use of hormonal contraception, problems with the gastric mucosa and, above all, a poorly varied and highly processed diet. 
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Aleksandra Cudna.

Aleksandra Cudna Nutritionist

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We supplemented the resulting deficiency with an individualised whole food diet combined with a vitamin B12 supplement. I can see from experience that this combination works best, and the patient very quickly stops feeling the effects of the deficiency," adds the dietician.

See: 

I'm vegan! How do I make sure I have adequate levels of B12?

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Vegans and vegetarians often suffer from cobalamin deficienciesand. It is difficult to cover the daily requirement of this vitamin with fortified products alone. Therefore, people on a meat-free diet should additionally supplement vitamin B12 and monitor their levels. 

How can you supplement vitamin B12? You can read about this below.

Forms of administration of vitamin B12

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There are plenty of over-the-counter supplements with vitamin B12 in the form of: 

in pharmacies.
  • capsules, 
  • .
  • hard tablets,
  • .
  • effervescent tablets
  • .
  • drops,
  • .
  • liquids,
  • .
  • sprays,
  • .
  • gels,
  • .

The doctor may prescribe injections with vitamin B12 by prescription Injections intramuscular or deep subcutaneous are prescribed for :

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  • acute deficiencies,
  • .
  • absorption disorders,
  • .
  • pain relief (e.g. neuropathy, sciatica),
  • .
  • life and health emergencies,
  • .

Consult your doctor or pharmacist if you are unsure what form of administration will work best for you and whether it will interfere with other medicines/supplements.

Vitamin B12 in the diet - advice from a nutritionist

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Tips from an expert - how to ensure an adequate supply of B12 in your diet:

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    .
  • Diversity. Try to use a variety of zoonotic food groups on a daily basis, don't just rely on meat alone.
  • Include eggs, milk and dairy products - cream cheese, cottage cheese, yoghurt, kefir - in your diet.
  • .
  • Attempt to eat fish and seafood. Steam it, make pastes, try it out!
  • Cook and eat it.
  • Use products fortified with vitamin B12. Nowadays, we can get fortified breakfast cereals, vegetable drinks, soy products, yeast flakes or energy bars on the market. 
  • Remember to include a source of complete protein, preferably of animal origin, in each of your meals. 

Example menu - variety throughout a day of healthy eating!

. . . . .
Food Proposal
Breakfast Warming shakshuka or spinach omelette
Breakfast.
Second breakfastYogurt with seasonal fruit, granola and flaxseed
Second breakfast.
Lunch Lean poultry meat (chicken, turkey) or fatty fish (salmon, halibut), favourite vegetables and porridge/brown rice/potatoes
Cooked meat.
Afternoon snackWheat cheese or cottage cheese with tomato and chives
Afternoon snack.
DinnerCaprese salad with mozzarella cheese
Salad.

To ensure adequate absorption of vitamin B12, avoid stimulants - smoking, alcohol consumption, excessive amounts of coffee.

 See also other articles on B vitamins:

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Summary

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Vitamin B12 deficiency can have deplorable consequences as it has a multisystemic impact on our health and wellbeing. 

With your nutritionist, we encourage you to change your eating habits and get vitamins and minerals from your diet. You may find that additional supplementation will lead to unnecessary vitamin excess or you may be spending money down the drain - because you have optimal levels.

Did you know that vitamin B12 has such versatile effects on our bodies? Did anything surprise you? Leave a comment, I'm curious - I was surprised more than once when writing the article!

I invite you to other interesting posts about vitamins and minerals.

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FAQ

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. How to quickly correct a vitamin B12 deficiency?.

The quickest and most effective way to increase vitamin B12 is to eat animal-based foods, which are the best source of it. You can also support yourself with dietary supplements or over-the-counter medications with vitamin B12. It is worth discussing the dose and supplementation plan with your doctor.

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. What leaches vitamin B12 from the body?.

Alcohol and nicotine flush vitamin B12 out of the body, which can lead to vitamin B12 deficiency. Vitamin B12 deficiency is often diagnosed in alcohol abusers and compulsive smokers.

. Does vitamin B12 deficiency cause neurological symptoms?.

Neurological symptoms of vitamin B12 deficiency include: headaches and dizziness, muscle pain, weakness and fatigue, sensory disturbances, paresthesias (numbness, tingling, burning), ataxia (reduced coordination of movements and trouble with balance).

. Does vitamin B12 calm the nerves?.

Yes, the B vitamins, including vitamin B12 have a huge impact on the nervous system, mood and psyche. Deficiencies of these vitamins can manifest as lowered mood and mental fatigue. It is worth taking care of an adequate supply of these vitamins or supplementation to enjoy mental health and physical health.

. After how long does vitamin B12 take to take effect?.

How quickly it takes to correct a vitamin B12 deficiency is an individual matter of the body, the level of deficiency and the dose of medication or dietary supplement taken. Typically, after about two weeks of regular supplementation, blood levels of vitamin B12 should increase.

. How to treat vitamin B12 deficiency?.

Treating vitamin B12 deficiency involves adding foods rich in the vitamin to the diet and taking dietary supplements or medication in appropriate doses. The doctor may also decide to give intramuscular injections.

. How much does a blood test for vitamin B12 levels cost?.

The price of testing the concentration of vitamin B12 in the blood depends on the laboratory. Prices range from £47 to £60. You can also ask your internist or endocrinologist for a referral for the test under the National Health Service, for which you will not pay.

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Resources

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. See all.

Afra, T. P., Razmi, T. M., & Narang, T. (2020). Reversible Melanonychia Revealing Nutritional Vitamin-B12 Deficiency. Indian Dermatology Online Journal, 11(5), 847-848. https://doi.org/10.4103/idoj.IDOJ_13_20

Ankar, A., & Kumar, A. (2022). Vitamin B12 Deficiency. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK441923/

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Ata, F., Bint I Bilal, A., Javed, S., Shabir Chaudhry, H., Sharma, R., Fatima Malik, R., Choudry, H., & Bhaskaran Kartha, A. (2020). Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report. Annals of Medicine and Surgery, 60, 316-322. https://doi.org/10.1016/j.amsu.2020.11.010

Baik, H. W., & Russell, R. M. (1999). Vitamin B12 deficiency in the elderly. Annual Review of Nutrition, 19, 357-377. https://doi.org/10.1146/annurev.nutr.19.1.357

Berenson, A. B., & Rahman, M. (2012). Effect of hormonal contraceptives on vitamin B12 level and the association of the latter with bone mineral density. Contraception, 86(5), 481-487. https://doi.org/10.1016/j.contraception.2012.02.015

Boumenna, T., Scott, T. M., Lee, J.-S., Palacios, N., & Tucker, K. L. (2021). Folate, vitamin B-12, and cognitive function in the Boston Puerto Rican Health Study. The American Journal of Clinical Nutrition, 113(1), 179-186. https://doi.org/10.1093/ajcn/nqaa293

Gupta, K., Jain, A., & Rohatgi, A. (2018). An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy. Diabetes & Metabolic Syndrome, 12(1), 51-58. https://doi.org/10.1016/j.dsx.2017.08.014

Jatoi, S., Hafeez, A., Riaz, S. U., Ali, A., Ghauri, M. I., & Zehra, M. (n.d.). Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus, 12(2), e6976. https://doi.org/10.7759/cureus.6976

Kobayashi, A., & Iwasaki, H. (2020). Pernicious anemia presenting as glossitis. CMAJ : Canadian Medical Association Journal, 192(16), E434. https://doi.org/10.1503/cmaj.191331

Sharabi, A. F., & Winters, R. (2022). Glossitis. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK560627/

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Wolffenbuttel, B. H. R., Wouters, H. J. C. M., Heiner-Fokkema, M. R., & van der Klauw, M. M. (2019). The Many Faces of Cobalamin (Vitamin B12) Deficiency. Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 3(2), 200-214. https://doi.org/10.1016/j.mayocpiqo.2019.03.002

Xu, J., Xu, Z., Ge, N., Wang, C., Hu, C., Chen, Z., Ouyang, J., & Pei, C. (2021). Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction-A cross-sectional study. Andrology, 53(11), e14234. https://doi.org/10.1111/and.14234

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Meet the team
Nina Wawryszuk - Author

Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Alexandra Cudna-Bartnicka - Reviewed by

Clinical nutritionist

Verified by an expert

Clinical nutritionist whose main area of interest is nutrition in diseases and functional disorders of the digestive system.

Michael Tomaszewski - Edited by

Editor

Michael Tomaszewski

Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

Nina Wawryszuk - Fact-checking

Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

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