Piperine - action, properties, side effects. When are the first effects?

Piperine is the main ingredient in pepper, which shows health-promoting effects on our body.

Nina Wawryszuk - AuthorAuthorNina Wawryszuk
Nina Wawryszuk - Author
AuthorNina Wawryszuk
Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

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Michael Tomaszewski - Edited byEdited byMichael Tomaszewski
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Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

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Piperine - action, properties, side effects. When are the first effects?
29 April, 2024
13 min
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The piperine contained in pepper is responsible for its health-promoting properties. It is due to its action that pepper is used in natural medicine. 

After reading this article, you will never look at pepper in the same way. When seasoning a dish or taking a pinch of pepper in your fingers, you will experience its smell as a harbinger of health-promoting benefits. Check out the properties of piperine as described in scientific studies.

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From this article you will learn:

  • What is piperine
  • .
  • What its effects and properties are
  • .
  • How to dose piperine safely
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  • What are the contraindications and side effects of piperine
  • .

See also:

What is piperine?

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Piperine is one of the main ingredients in pepper. It gives this spice a peppery taste and aroma. The greatest amount of piperine is found in black, white, green and coloured pepper, respectively. Piperine is an alkaloid, a naturally occurring chemical compound with multifaceted effects on the human bodyand.

Natural medicine has used piperine for thousands of years to treat and alleviate many ailments. Only recently have scientists been looking closely at its properties. Research is underway that may, in the future, result in the implementation of piperine as an additional ingredient to assist in the treatment of many conditionsand.

There is relatively little piperine in pepper. It is only pepper extracts that contain the amounts needed to have an effective effect on our body. Piperine is obtained as an extract from black pepper or, less commonly, by chemical synthesis . We will not realise the full potential of piperine by consuming pepper alone.

Piperine - effects and properties

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The most important properties of piperine are: increasing the bioavailability of nutrients and drugs (by up to 30%-200%), supporting weight loss, anti-inflammatory, anti-microbial and antioxidant effects, and supporting the nervous, cardiovascular and digestive systemsand.

Piperine has long been under the magnifying glass of scientists, with a growing body of research findings confirming its unique properties for healthand.

What does the scientific research to date suggest about the effects of piperine on different areas of our health?

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Piperine for weight loss

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Piperine may support weight loss by: inhibiting appetite, regulating carbohydrate and fat metabolism and increasing thermogenesisand.

Remember that the cornerstone of weight reduction is a calorie deficit . For best results, include your favourite activity and nutritious diet. Treat piperine supplementation as a support, not the main remedy for overweight.

Check out articles on chromium and berberine, both of which have been attributed with weight-loss properties.

Powerful antioxidant

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Today we are exposed to large amounts of free radicals - unstable molecules that can damage body cellsand. This is promoted by stress, fatigue, diet, as well as exposure to pollution, cigarette smoke and sunlight .

Research suggests that piperine is a potent antioxidant that may help prevent or delay the damaging effects of free radicals by eliminating them. A diet rich in antioxidants has been linked to reduced risk of certain diseases (e.g. cancer) and delayed ageingand. It also reduces harmful oxidative stress.

Anti-inflammatory potential

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Chronic inflammation can contribute to the development of diseases such as rheumatoid arthritis, heart disease and cancerand. Piperine is currently being studied to prevent or inhibit the development of inflammation in the body. Animal studies look promising - perhaps in a few years' time piperine will support the treatment of many inflammatory diseases 

Increases bioavailability of nutrients and drugs

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Piperine can increase the bioavailability of certain nutrients and drugs by up to 30%-200% . The mechanisms of this effect depend on, among other things, the substance in question and the state of the gut.

Piperine can increase absorption :

  • minerals (e.g. calcium, selenium, iron), 
  • vitamins (e.g. B vitamins and vitamins A, D, E, K),
  • some compounds contained in plants (e.g. polyphenols in green tea, curcumin from curcumin),
  • drugs (e.g. rifampicin, nevirapine, isoniazid, pyrazinamide, ethambutol)
  • .

Cancer

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In vitro studies suggest that piperine slows replication (growth) of breast, prostate and colon cancer cells and induces cancer cell deathand. Human studies are needed to learn more and understand the exact mechanism of action of piperine. At this point, we are keeping our fingers crossed for the researchersand.

Nerve system

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In animal studies, piperine has shown potential benefits for symptoms associated with degenerative brain diseases such as Alzheimer's and Parkinson's disease 

The compound improved memory and reduced the formation of amyloid plaques, which are clusters of harmful protein fragments in the brain linked to Alzheimer's disease 

Digestive system

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Piperine cares for our digestive system in several ways: it can increase the amount of good bacteria in the gut, improves digestion by increasing the secretion of gastric juices and stimulating the secretion of pancreatic enzymes .

Lipid profile

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Animal studies have shown that piperine lowers total cholesterol and 'bad' cholesterol (LDL), and increases 'good' cholesterol (HDL)and. These are very promising results, and in the future piperine may be an effective support for the treatment of obesity and cardiovascular disease.

Blood glucose metabolism

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Piperine may improve insulin sensitivity and reduce blood sugar spikes. Proper sugar metabolism prevents sudden hunger attacks and the development of metabolic diseases (e.g. osteoporosis, type II diabetes)and.

Libido

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Today we are exposed to stress, which can have an adverse effect on lowering libido. As far back as traditional Indian and Chinese medicine, piperine has been used as an aphrodisiac and remedy for sexual dysfunction. Modern research suggests its positive effects on erection in menand.

Antimicrobial activity

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Piperine has been shown to have antibacterial propertiesand. Studies suggest that black pepper extract fights bacteria such as Staphylococcus aureus, Escherichia coli and Chromobacterium violaceum .

Support for the treatment of depression

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Animal studies to date suggest that piperine may have an antidepressant effect . Researchers are looking at combining different natural active ingredients (e.g. piperine with resveratrol). The synergistic effect obtained from these combinations may provide clues for the design of innovative antidepressants with high efficacy and rare side effects 

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Summary

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On the internet you will find many articles assuring you of the amazing properties of piperine. Keep in mind that most of these are animal studies. Piperine supplementation will certainly benefit you, but let it be an addition, a supplement to a nutritious diet and exercise, which are the cornerstones of health.

Piperine - when do the first effects occur?

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You may notice the first effects of piperine after approximately4-8 weeks of daily supplementation with 5-10 mgand. Depending on your expectations, you may want to record the date you started supplementation and your initial condition (e.g. lipid profile test results, waist circumference) and check these parameters after 4 weeks. Remember that piperine does not work on an ad hoc basisand.

Have a tendency to forget to take pills? 

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  • Purchase piperine, which is consumed once a day.
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  • Set up a cyclical supplementation reminder on your smartphone.
  • Set up a daily supplementation reminder.
  • Set up a daily ritual, such as a piperine tablet for the second breakfast or after dinner.
  • .
  • If you have a product that requires several servings a day, buy a graduated pill container.
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  • When buying a supplement, calculate how long you will need 1 packet for. Consider making a stockpile so you don't stop supplementation.
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Regular consumption of piperine, combined with a varied diet and physical activity, can bring many benefits. Feel like a scientist and see after 4 weeks if something you've been waiting for has changed (e.g. smaller waist circumference, better blood test results).

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Piperine is considered safe when supplemented at 5 to 10 mg per day and. Manufacturers in Poland offer several forms of piperine administration and different contents per serving, so always follow the directions on the leaflet. 

The amount of piperine depends on the species of pepper, e.g. black pepper contains approximately 2-7.4%and. Wanting to exploit the potential of this spice, fortunately we don't have to add pepper to literally everything (which can end up irritating the stomach!) 

A resolution of the Dietary Supplements Panel of the Sanitary and Epidemiological Council dated 04/02/2022 indicated a maximum daily allowance of piperine for adults of 2 mg .  

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There is a lack of research into the long-term use of piperine in larger quantities - use common sense and bet, regular supplementation with products from proven manufacturers, rather than shock doses that don't work and can only cause multiple disorders 
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Dr Witold Tomaszewski.

Witold Tomaszewskidoctor of medical sciences

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Contraindications to the use of piperine

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Piperine contraindications include: hypersensitivity to black pepper, pregnancy, breastfeeding, blood clotting disorders, use of high blood pressure medication, antidepressants, antidiabetics. Piperine should not be consumed by children or people expecting surgeryand.

Piperine side effects

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In some people, piperine may cause side effects such as gastrointestinal complaints (zgaga, nausea), coughingand. Piperine is generally considered safe for supplementation, with side effects common with excessive supplementationand.

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These side effects usually affect people who use excessive amounts of piperine. The unpleasant symptoms of piperine excess should subside on their own, and to avoid them in the future, moderation is important.
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Dr Witold Tomaszewski.

Witold Tomaszewskidoctor of medical sciences

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Interactions

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Piperine may interfere with the absorption of some drugs  (digoxin, theophylline) or potentiate their effects (diclofenac, carbamazepine, chlorzoxazone) 

If you are unsure if you or a loved one is taking these substances, and you want to start piperine supplementation - consult your doctor for safety.

Piperine - which is the best?

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When looking for the best piperine supplement, we should look at:

  • Concentration of piperine -preferably above 95%.
  • Concentration of piperine.
  • Active ingredients that support the action of piperine (e.g. ginger, turmeric).
  • Active ingredients that support the action of piperine (e.g. ginger, turmeric).
  • Form of administration, which should be convenient for us (capsules, tablets, syrup).

Also, when buying piperine, pay attention to other medicines and supplements you are taking. If in doubt, ask your doctor or pharmacist.

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Best for the liver

Pharmovit Curcumin + Piperine

Pharmovit Curcumin + Piperine
4.9
  • Curcumin content: 237.50 mg
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  • Additional active ingredients: micronized apple pomace, black pepper fruit extract (including piperine)
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  • Form: capsules
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  • Dose: 1 capsule daily
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  • Sufficient for: 90 days
  • .
See price
in the Natu.Care shop
Product description

Curcumin + Piperine Pharmovit is a dietary supplement that supports liver health, fatódigestion, joints and the immune system. Long Oyster Extract provides up to 237.50 mg of curcumin, while Black Pepper Fruit Extract contains 9.50 mg of piperine. 

The supplement has no fillers or colourings 

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Pros and cons

Curcumin + Piperine Pharmovit is a dietary supplement that supports liver health, fatódigestion, joints and the immune system. Long Oyster Extract provides up to 237.50 mg of curcumin, while Black Pepper Fruit Extract contains 9.50 mg of piperine. 

The supplement has no fillers or colourings 

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Additional information

Curcumin + Piperine Pharmovit is a dietary supplement that supports liver health, fatódigestion, joints and the immune system. Long Oyster Extract provides up to 237.50 mg of curcumin, while Black Pepper Fruit Extract contains 9.50 mg of piperine. 

The supplement has no fillers or colourings 

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Standardised extract

YANGO Turmeric - extract + piperine

YANGO Turmeric - extract + piperine
4.4
  • Curcumin content: 750 mg (no information on curcuminoidócontent)
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  • Form: capsules
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  • Dose: 2 capsules daily
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  • Sufficient for: 30 days
  • .
See price
in the Natu.Care shop
Product description

Turmeric extract 10:1 combined with turmeric root powder and the addition of piperine, whichóra increases the bioavailability of the active ingredients.

Pros and cons

Turmeric extract 10:1 combined with turmeric root powder and the addition of piperine, whichóra increases the bioavailability of the active ingredients.

Additional information

Turmeric extract 10:1 combined with turmeric root powder and the addition of piperine, whichóra increases the bioavailability of the active ingredients.

Simple composition

Primabiotic Turmeric + piperine

Primabiotic Turmeric + piperine
4.8
  • Turmeric content: 400 mg rhizome extract curcumin, including 380 mg curcuminoids
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  • Additional active ingredients: piperine
  • Form: capsules
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  • Dose: 1 capsule per day
  • .
  • Sufficient for: 60 days
  • .
See price
in the Natu.Care shop
Product description

The product will support liver function and improve digestion. It will have a beneficial effect on the circulatory system. Supplementation with turmeric may be helpful in the treatment of chronic inflammation      

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The addition of piperine improves the absorption of turmeric into the body for maximum supplementation effects.

Pros and cons

The product will support liver function and improve digestion. It will have a beneficial effect on the circulatory system. Supplementation with turmeric may be helpful in the treatment of chronic inflammation      

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The addition of piperine improves the absorption of turmeric into the body for maximum supplementation effects.

Additional information

The product will support liver function and improve digestion. It will have a beneficial effect on the circulatory system. Supplementation with turmeric may be helpful in the treatment of chronic inflammation      

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The addition of piperine improves the absorption of turmeric into the body for maximum supplementation effects.

Best for digestion

Sundose° Daily Lightness°

Sundose° Daily Lightness°
4.8
  • Active ingredients: caraway extract, artichoke extract, curcumin, piperine and probiotics
  • Form: capsules + powder
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  • Dose: 1 sachet + 3 hard capsules
  • Sufficient for: 30 days
  • .
See price
in the Natu.Care shop
Product description

Sundose° Daily Lightness° is a formula thatós supports the stomach and liver, reduces the frequency of gasóing and bloating, and supports optimal digestion. The formula contains no unnecessary additivesós, and the composition of the active ingredients (e.g. curcumin with piperine) mutually enhances their absorption.
The dietary supplement from Sundose comes in two flavour versions: orange and green.

Pros and cons

Sundose° Daily Lightness° is a formula thatós supports the stomach and liver, reduces the frequency of gasóing and bloating, and supports optimal digestion. The formula contains no unnecessary additivesós, and the composition of the active ingredients (e.g. curcumin with piperine) mutually enhances their absorption.
The dietary supplement from Sundose comes in two flavour versions: orange and green.

Additional information

Sundose° Daily Lightness° is a formula thatós supports the stomach and liver, reduces the frequency of gasóing and bloating, and supports optimal digestion. The formula contains no unnecessary additivesós, and the composition of the active ingredients (e.g. curcumin with piperine) mutually enhances their absorption.
The dietary supplement from Sundose comes in two flavour versions: orange and green.

3 valuable ingredients

OstroVit Curcumin + Black Pepper + Ginger

OstroVit Curcumin + Black Pepper + Ginger
4.7
  • Curcumin content: 300 mg, including 285 mg curcuminoidsów
  • .
  • Other active ingredients: piperine, ginger
  • Form: capsules
  • .
  • Dose: 1 capsule
  • .
  • Sufficient for: 90 days
  • .
See price
in the Natu.Care shop
Product description

Preparation with standardised extracts with herbal ingredients thatóre positively influencing the functioning of the body. Curcumin improves digestion, has an antioxidant effect and supports jointós health. Ginger helps to reduce inflammationólation, has an anti-bioactive effect and is rich in antioxidants. Piperine increases the bioavailability of someós food substances, has anti-inflammatory effects and increases thermogenesis in the body.

Pros and cons

Preparation with standardised extracts with herbal ingredients thatóre positively influencing the functioning of the body. Curcumin improves digestion, has an antioxidant effect and supports jointós health. Ginger helps to reduce inflammationólation, has an anti-bioactive effect and is rich in antioxidants. Piperine increases the bioavailability of someós food substances, has anti-inflammatory effects and increases thermogenesis in the body.

Additional information

Preparation with standardised extracts with herbal ingredients thatóre positively influencing the functioning of the body. Curcumin improves digestion, has an antioxidant effect and supports jointós health. Ginger helps to reduce inflammationólation, has an anti-bioactive effect and is rich in antioxidants. Piperine increases the bioavailability of someós food substances, has anti-inflammatory effects and increases thermogenesis in the body.

Natural ingredients

Primabiotic for digestion

Primabiotic for digestion
4.7
  • Turmeric content: 100 mg  extract of long-stemmed thistle, including 95 mg curcumin
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  • Additional active ingredients: piperine, rosemary extract, fennel extract, peppermint extract, bromelain, artichoke extract, dandelion extract
  • Form: capsules
  • .
  • Dose: 1 capsule 2 times daily
  • .
  • Sufficient for: 30 days
  • .
See price
in the Natu.Care shop
Product description

A herbal blend to improve digestion. It will support the liver, stomach, intestines and kidneys. The natural ingredients effectively deal with flatulence, troublesome belching or a feeling of heaviness in the stomach.

The addition of piperine ensures optimal absorption of the ingredients.

The addition of piperine ensures optimal absorption of the active ingredients into the body, so supplementation is more effective.

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Pros and cons

A herbal blend to improve digestion. It will support the liver, stomach, intestines and kidneys. The natural ingredients effectively deal with flatulence, troublesome belching or a feeling of heaviness in the stomach.

The addition of piperine ensures optimal absorption of the ingredients.

The addition of piperine ensures optimal absorption of the active ingredients into the body, so supplementation is more effective.

.
Additional information

A herbal blend to improve digestion. It will support the liver, stomach, intestines and kidneys. The natural ingredients effectively deal with flatulence, troublesome belching or a feeling of heaviness in the stomach.

The addition of piperine ensures optimal absorption of the ingredients.

The addition of piperine ensures optimal absorption of the active ingredients into the body, so supplementation is more effective.

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Piperine - expert opinions

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Is piperine supplementation worth trying? Read what your doctor and nutritionist think about it.

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Piperine used sensibly and based on the recommendations of a doctor, can be a good support for the treatment of many ailments.  In the future, piperine may prove to be a valuable addition to many therapies, which will interestingly show how conventional medicine can be effectively combined with what nature offers. 
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Dr Witold Tomaszewski.

Witold Tomaszewskidoctor of medical sciences

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Piperine supplements have many research-proven properties. Particularly noteworthy is piperine's increased bioavailability of elements and vitamins. This is important because piperine thus helps to better nourish the body and support it in times of greater need. 
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Julia Skrajda.

Julia SkrajdaDietitian

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See also articles on health:

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Summary

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The use of natural spices to treat various ailments is a practice that has been used successfully for thousands of years. Nowadays, thanks to the work of scientists, we can more and more accurately select a spice and its active ingredients for our ailments.

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Piperine in a nutshell... knowledge:

  • Piperine is the active ingredient found in pepper.
  • .
  • In studies, it has been shown to have anti-inflammatory and antioxidant effects.
  • Piperine is an active ingredient found in pepper.
  • It can help with weight loss, and achieves best results when combined with a reduction diet and exercise.
  • .
  • Has anti-cancer and antidepressant potential, but further research is needed.
  • .
  • Has a strong effect on the absorption of some drugs, supplements and nutrients.
  • .
  • Pregnant and lactating women and children should not supplement with piperine. If you are undergoing chronic medical treatment, also consult piperine consumption with your healthcare provider.
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FAQ

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. Whether piperine is safe for health concerns.

Yes, piperine is considered safe for health. However, it is important to note that despite its natural origin, there are contraindications to its supplementation. Interactions and effects on the absorption of other substances should be considered, as well as not exceeding the manufacturer's recommended doses.

. Does piperine lose weight?.

No, piperine by itself does not cause fat loss. Instead, it is a good complement to a reducing diet and physical activity, due to its potential to accelerate metabolism and thermogenesis. It has the best effects when combined with curcumin.

. Can you drink pepper with water on an empty stomach?.

Yes, you can drink pepper with water on an empty stomach. Caution should be exercised by those with sensitive stomachs and those suffering from gastric and duodenal ulcers - in these two cases it is strongly discouraged.

. What are the benefits of drinking pepper water?.

Drinking pepper water increases the secretion of gastric acids, stimulates the secretion of pancreatic enzymes and this improves digestive processes. In addition, it has an anti-inflammatory and antibacterial effect.

. Does piperine raise blood pressure?.

No, piperine does not raise blood pressure. Piperine lowers and regulates blood pressure in cases of hypertension. If you are unsure whether you can take piperine and you have high blood pressure and are taking medication, please consult your doctor.

. What is the most piperine in?.

Naturally, most piperine is found in the fruits of black, white, green and coloured pepper. Large amounts of piperine can also be found in piperine supplements or in the combination of curcumin with piperine.

. Does pepper have calories?.

Yes, black pepper has 251 kcal/100 g. One pinch has virtually no energy value. However, this inconspicuous powder has plenty of nutritional value, containing B vitamins, vitamin A, vitamin K and potassium, magnesium and iron.

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Butt, M. S., Pasha, I., Sultan, M. T., Randhawa, M. A., Saeed, F., & Ahmed, W. (2013). Black Pepper and Health Claims: A Comprehensive Treatise. Critical Reviews in Food Science and Nutrition, 53(9), 875-886. https://doi.org/10.1080/10408398.2011.571799

Chronic diseases, inflammation, and spices: How are they linked? | Journal of Translational Medicine | Full Text. (n.d.). Retrieved 15 March 2023, from https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1381-2

Haq, I.-U., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S. (2021). Piperine: A review of its biological effects. Phytotherapy Research, 35(2), 680-700. https://doi.org/10.1002/ptr.6855

Maeda, A., Shirao, T., Shirasaya, D., Yoshioka, Y., Yamashita, Y., Akagawa, M., & Ashida, H. (2018). Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Molecular Nutrition & Food Research, 62(11), 1800086. https://doi.org/10.1002/mnfr.201800086

Parim, B., Harishankar, N., Balaji, M., Pothana, S., & Sajjalaguddam, R. R. (2015). Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats. Pharmaceutical Biology, 53(9), 1318-1328. https://doi.org/10.3109/13880209.2014.980585

Rondanelli, M., Opizzi, A., Perna, S., Faliva, M., Solerte, S. B., Fioravanti, M., Klersy, C., Edda, C., Maddalena, P., Luciano, S., Paola, C., Emanuela, C., Claudia, S., & Donini, L. M. (2013). Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects. Endocrine, 44(2), 391-401. https://doi.org/10.1007/s12020-012-9863-0

Srinivasan, K. (2007). Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects. Critical Reviews in Food Science and Nutrition, 47(8), 735-748. https://doi.org/10.1080/10408390601062054

Kesarwani, K., & Gupta, R. (2013). Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal of Tropical Biomedicine, 3(4), 253-266. https://doi.org/10.1016/S2221-1691(13)60060-X

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Meet the team
Nina Wawryszuk - Author

Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Witold Tomaszewski - Reviewed by

Doctor of Medicine

Verified by an expert

Doctor of Medicine, food and pharmaceutical law expert and experienced medical professional.

Michael Tomaszewski - Edited by

Editor

Michael Tomaszewski

Graduate of Journalism and Artes Liberales at the University of Warsaw. Since 2017, he has been working with the biggest portals in Poland and abroad as an editor. Previously worked for 3 years in one of the leading pharmaceutical companies - he knows the health and beauty industry inside out. In his free time, he most enjoys playing tennis or skiing.

Gregory Dill - Fact-checking

Fact-checker

Gregory Dill

Grzegorz Koper is in charge of verifying quoted sources and checking that published content is truthful.

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