What not to mix with ashwagandha? Interactions + examples
Ashwaghanda is an adaptogen that influences the effects of medicines, supplements and herbal preparations.
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.Ashwagandha in combination with certain plants or active substances enhances each other's effects. Sometimes you want to more calm down or give yourself more energy, so you put on your alchemist's hat and combine. Maybe classically you want to do well, and ashwagandha is just a plant after all...
Unfortunately, some combinations may harm you, as ashwagandha is a potent adaptogen, not... siano. So before you create your 'stack' with ashwagandha, ask your Master Alchemist (doctor) for his/her opinion and find out what are the explosive combinations with ashwagandha.
From this article you will learn:
- With which medicines, supplements and herbs not to combine ashwagandha.
- What are the contraindications to the use of this plant.
- How to use ashwagandha safely.
- What are the benefits of using ashwagandha.
See also:
- Ashwagandha
- Ashwagandha - dosage
- Ashwagandha - contraindications to use
- Ashwagandha - side effects
- Ashwagandha - morning or night?
- Ashwagandha - when does it start working?
- Indian ginseng
- Adaptogens
Ashwagandha - what not to combine with?
Ashwagandha should not be combined with medications: for thyroid, blood thinners, immunosuppressants, sleeping pills, sedatives, antihistamines, antidiabetics, contraceptives, antiepileptics and blood pressure regulators . Combining it with these agents may, for example, increase sedative effects.
Ashwagandha may also weaken or exacerbate the effects of the drugs themselves, which negatively affects health.
Also, ashwagandha should not be combined with alcohol and dietary supplements or herbs with calming, sedative effects containing valerian or St. John's wort .
Interactions of ashwagandha with medications
Below you will find a table with groups of medications that should not be used concurrently with ashwagandha along with examples given of the most popular preparations available .
|
Group of drugs |
Examples of medicines available in Poland |
|
Regulating hormones thyroid |
Letrox, Eurhyrox, Thyrozole |
|
Used in the treatment of depression, anxiety |
Cital, Dulsevia, Pramolan, Anafranil, Amitriptyline, Fevarin, Xanax, Parogen |
|
Regulating high blood pressure |
Torsemed, Captopril, Prestarium, Telmizek, Hydrochlorothiazide |
|
Blood thinners (anticoagulants) |
Warfin, Pradaxa, Xarelto, Aspirin, Acard |
|
Immonosuppressants |
Metypred, Prograf, Equoral, Endoxan, Azathioprine |
|
Somnolent |
Miansen, Mirror, Zopiclone, Zolpidem, Trittico |
|
Antidiabetic |
Pioglitazone, Metformax, Amaryl, Forxiga, Jardiance |
|
Antihistamines |
Allertec, Clatra, Lirra Gem, Zyrtec, Clatra |
|
Antiepileptic |
Sabril, Zonisamidum Neuraxpharm, Milocardin, Rivotril, Hydacorn |
The use of ashwagandha with these medications may intensify, reduce or nullify their effects . Before taking ashwagandha preparations or teas, consult your doctor.
Sleep with Benefits – Vegan Sleep Gummies, Ashwagandha KSM-66, Raspberry Flavor
Supports better sleep and stress reduction (ashwagandha). Promotes relaxation and cognitive function (L-theanine). Has a positive effect on the nervous system (passionflower).
- Main active ingredient: 10:1 extract of ashwagandha root (Withania somnifera) KSM-66®
- Amount of main active ingredient: 100 mg
- Standardization: 5% withanolides
- Other ingredients: L-theanine 98 mg, Passionflower herb extract 34 mg, L-tryptophan 200 mg
- Daily serving: 2 gummies
- Packaging: 60 gummies
- Sufficient for: 30 days
Product description
Supports better sleep and stress reduction, promoting relaxation and cognitive functions. It also has a positive effect on the nervous system. The vegan Sleep with Benefits gummies use KSM-66® ashwagandha – the most researched, highest quality extract from the root of Withania somnifera.
The product is sugar-free – each gummy contains only 6 kcal! Sleep with Benefits is available in two flavors: pineapple and raspberry.
Pros and cons
Pros:
- Highest quality Ashwagandha – KSM-66®
- Well-balanced, simple ingredients
- No melatonin (which may allow combining this supplement with others that contain it)
- Fantastic raspberry or pineapple flavor
Cons:
- Reasonable doses of active ingredients may be perceived as "weak" – remember that this is a dietary supplement, and calming substances can amplify each other's effects. Additionally, this supplement was also designed as a complement to other supplements that may contain melatonin or ashwagandha.
Goli Ashwagandha
- Active ingredient: KSM-66® Ashwagandha root extract
- Quantity of active substance: 150 mg of KSM-66® Ashwagandha, 12,5 mcg of vitamin D
- Form: gummies
- Daily serving: 2 gummies a day
- Packaging: 60 gummies
- Sufficient for: 30 days
Product description
These gummies are a convenient way to enjoy the health benefits of ashwagandha, a powerful adaptogen known for its ability to help manage stress, support relaxation, and improve overall well-being.
Pros and cons
Pros:
- Highest quality of ashwagandha – KSM-66®
- Vitamin D supports immune health and mood alongside the ashwagandha benefits.
- Suitable for individuals following gluten-free or plant-based diets
Cons:
- Contains sugar - in one gummy there are approximately 2 grams of sugar.
Lemme Chill De-stress Gummies
- Active ingredient: KSM-66® Ashwagandha root extract
- Quantity of active substance: 300 mg of KSM-66® Ashwagandha, 15 mg proprietary herbal blend (Passionflower, Lemon Balm, Goji Berry)
- Form: gummies
- Daily serving: 2 gummies a day
- Packaging: 60 gummies
- Sufficient for: 30 days
Product description
Enhanced with a botanical blend of Passionflower, Lemon Balm, and Goji Berry, Lemme Chill promotes a calm, relaxed state while helping manage stress.
Pros and cons
Pros:
- Highest quality of ashwagandha – KSM-66®
- Includes Passionflower, Lemon Balm, and Goji Berry for additional relaxation and rejuvenation benefits.
- Suitable for individuals following gluten-free or plant-based diets
Cons:
- High in sugar - in one gummy there are approximately 3 grams of sugar and 20 calories.
OLLY Goodbye Stress
- Active ingredients: Ashwagandha, GABA, L-Theanine, Lemon Balm
- Quantity of active substances: 125 mg Ashwagandha, 100 mg GABA, 100 mg L-Theanine, 75 mg Lemon Balm
- Form: softgels
- Daily serving: 2 softgels per day
- Packaging: 60 softgels
- Sufficient for: 30 days
Opis produktu
OLLY Ultra Strength Goodbye Stress Softgels combine Ashwagandha, GABA, L-Theanine, and Lemon Balm to help reduce stress and promote calm. Keep your cool thanks to this soothing mix and decrease mental tension.
Pros and cons
Pros:
- Contains additional ingredients synergistic with ashwagandha
- Suitable for individuals following gluten-free diet
- Sugar free
Cons:
- No information about standardization
- For some people softgels can be hard to swallow
Nature Made Ashwagandha
- Main active ingredient: SENSORIL® Ashwagandha
- Amount of main active ingredient: 125 mg
- Standardization: 10% withanolides
- Other ingredients: None
- Daily serving: 1 capsule
- Packaging: 60 capsules
- Sufficient for: 60 days
Product description
Clinically studied, SENSORIL® Ashwagandha helps reduce cortisol and feelings of stress as well as promotes relaxation.
Pros and cons
Pros:
- High quality Ashwagandha – SENSORIL®
- The package lasts for long - 2 months
- Gluten-free, with no artificial flavors or preservatives
Cons:
- Doesn't contain additional ingredients
- For some people capsules may be hard to swallow
Products contain affiliate links
Ashwagandha vs antidepressants
Do not combine ashwagandha with antidepressants, as this plant has activity similar to some preparations used to treat depression through its effect on serotonin receptors .
Combining ashwagandha with certain medications results in interactions and may affect the efficacy and safety of prescribed pharmacotherapy.
Kacper Nihalani doctor
Antidepressant medicines
The drugs used to treat depression are divided into groups: SSRIs (selective serotonin reuptake inhibitors), SNRIs (serotonin-norepinephrine reuptake inhibitors), TLDs (tricyclic and quadricyclic antidepressants), MAOs (monoamine oxidase enzyme inhibitors) .
In 2021, the results of a study examining the effects of ashwagandha on generalized anxiety disorder (GAD, Generalized Anxiety Disorder) were published. Forty people taking SSRI drugs were divided into two groups in which they took:
- 1 g ashwagandha extract,
- placebo.
After 6 weeks, subjects taking SSRIs and the extract showed a reduction in the severity of GAD symptoms .
But this is only one study, conducted under controlled conditions. It cannot be concluded on its basis that concomitant use of SSRIs and ashwagandha is safe.
In other preclinical studies, ashwagandha has been found to affect GABAergic and serotonin activity, which are important pathways for the mechanism of action of SSRIs, so it is better not to use these concomitantly.
SSSRI drugs are metabolised by CYP450 enzymes. There are currently no study results showing that ashwaghandha affects this important metabolic pathway. Many drugs, as well as alcohol, caffeine and nicotine, are metabolised by these enzymes.
.
Kacper Nihalani doctor
Ashwagandha and alcohol
Do not drink alcohol while taking ashwagandha preparations or teas. Alcohol is a psychoactive substance, specifically a depressant .
Ashwagandha induces the release of neurotransmitters that have an inhibitory effect on the central nervous system, meaning that signals between nerve cells are transmitted more slowly.
.
Kacper Nihalani doctor
Scientific research suggests that ashwagandha may play a role in regulating detoxification enzyme activity and participate in the cleansing process at the cellular level .
Alcohol has a toxic effect on the body, so the simultaneous use of these substances can cause a reduction in tolerance to alcoholic beverages, and can lead to unpleasant discomforts such as drowsiness, headache, stomach discomfort and kac-gigant.
Ashwagandha versus other plants
Consider dietary supplements and herbs with calming, sedative and sleep-enhancing effects. Ashwagandha can also exacerbate their properties in adverse ways, causing 'fogginess', concentration problems or excessive daytime sleepiness .
Ashwagandha should not be combined with valerian and wort . There are no scientific studies verifying the effects of using these herbs simultaneously. Due to their similar action profile, they may exacerbate each other's sedative and sleeping properties.
Focus on quality, not quantity. Test the effects of different preparations, but not all at once, as this may do more harm than good.
Test the effects of different herbs.
Power of plants
Valerian is known for its sedative, anti-anxiety and anticonvulsant properties. Studies have shown that valerian extracts can affect the dopaminergic and serotonergic systems .
Ashwagandha versus other adaptogens
"Stacking" adaptogens, i.e. combining different plants and fungi in this group, aims to naturally harness the synergy of different substances that complement or potentiate each other's effects.
Ashwagandha can be combined with other adaptogens, and the most popular combinations involve plants and fungi such as :
Ashwagandha can also be combined with black cumin oil (for immunity and vitality), curcuma (reduces inflammation) with magnesium and vitamin B6 (for fatigue and stress) and guarana (to improve concentration). Piperine may increase the absorption of ashwagandha.
Some phytotherapy experts recommend that adaptogens should not be combined, but given to work separately. They suggest that only then will you get to know their effects on the body and more easily track down the 'culprit' of any side effects or see if they are working for you at all.
The use of adaptogens solo is recommended for inexperienced people who have not dealt with this type of substance before.
Ashwagandha and contraception
There are no scientific studies that test whether ashwagandha can be taken with contraceptive pills and what effect the plant has on their effectiveness in preventing pregnancy, so it is important to consult a gynaecologist before starting to take ashwagandha.
Ashwagandha and Contraceptive Pills.
Taking a variety of preparations, including those of plant origin, can affect the metabolism of substances supplied to the body. To avoid a potential interaction that may decrease effectiveness of hormonal contraception, maintain an interval of a few hours between taking ashwagandha and birth control pills.
How does it work?
Ashwagandha is 'suspected' of reducing the effectiveness of hormonal contraception, as other plants show such adverse properties, e.g. St. John's wort, plantain, sabal palm and alfalfa .
Combine for better absorption
There are some combinations you can indulge in. They naturally increase the absorption of ashwaghanda.
What is worth combining ashwagandha with?
- Piperine. It is an alkaloid known to increase the bioavailability of other nutrients. This means that ashwagandha can be absorbed into the body more efficiently thanks to piperine.
- Fat. Better absorption of ashwagandha is influenced by consuming it in the presence of healthy fats, e.g. eggs, avocado, olive oil, nuts, seeds.
How to use ashwagandha safely?
If you want to try ashwaghanda, do so with your head. Keep a few tips in mind:
- Check out the contraindications to use.
- Check out the potential contraindications to use.
- Learn about potential interactions between medicines, dietary supplements and herbal preparations and ashwaghanda.
- Consult with your doctor.
- Consult your doctor, who can best tell you how to use ashwagandha so that it does not interfere with other preparations you are taking.
What are the benefits of ashwagandha?
Ashwagandha (a.k.a. sluggish ginseng or Indian ginseng)can help with a variety of ailments and be a helpful support for their treatment. Previous scientific research suggests that this adaptogen may affect :
- Stress, anxiety and mental tension. Vitania osprey is known for its anti-anxiety effects, relieving stress and its negative effects on the body. It lowers cortisol (the so-called stress hormone) and supports mental health.
- Self-esteem. By reducing stress and improving quality of sleep it positively affects mood and motivation.
- Sleep disorders. Systematic intake of this plant can improve quality of sleep, by making it easier to fall asleep, calmer and increasing nighttime rest time.
- Mind fitness. Regular supplementation can improve memory and concentration, benefiting mental performance.
- Fatigue. Vitania sluggard may reduce feelings of fatigue and add energy. This may be linked to improved sleep quality - when you are sleepy, you have more desire to perform.
- Regeneration; Supports post-workout muscle recovery.
- Improves immune function. Supports immune system function.
- Antioxidation of the body. Eliminates harmful free radicals, reduces oxidative stress and reduces the negative consequences of their action.
- Male fertility. Increases sperm motility and improves semen quality.
- Hormone levels. Increases testosterone levels in infertile men. Increases levels of hormones thyroid T3 and T4.
- Libido levels. Ashwagandha may help treat sexual dysfunction in women.
- Cholesterol. Ashwagandha reduces 'bad' LDL cholesterol.
- Pain relief. Reduces pain during chemotherapy and in osteoarthritis.
- Conditioning. Supports the body's performance, especially in athletes doing endurance training, as it increases the aerobic ceiling.
Ashwagandha (also known as sleaze plant or Indian ginseng) has an adaptogenic effect, meaning it increases the body's resistance to stress and other adverse environmental factors .
are responsible for this action.
- vitanolides, or steroidal lactones (e.g. vitanopherin a, vitanolides a-y),
- alkaloids (e.g. vitanin, somniferin, anaferin),
- vitanolid glycosides (e.g. sitoindosides, vitanosides),
- flavonoids,
- saponins,
- coumarins,
Ashwaghanda is one of the best studied adaptogens with many potential benefits for the body. When used systematically, it can support health and well-being.
See also:
Analysis of dietary supplement compositions:
- Ashwagandha SFD
- Ashwagandha Aliness
- Ashwagandha Naturell
- Solgar's Ashwagandha
- Ashwagandha Swanson
- Swanson Berberine
- The best omega-3 fatty acids
- Best magnesium
- Best vitamin D3
- Best collagen
Summary
- Ashwaghanda should not be combined with specific groups of medications (including antidepressants, sleeping pills and anticoagulants), alcohol, and herbal preparations containing St. John's wort and valerian.
- Ashwaghanda should not be used in combination with other medications.
- Ashwaghanda, as a potent adaptogen, can affect the metabolism of drugs and enhance or weaken their effects, which nullifies the therapeutic effect and can be harmful to health.
- To avoid interactions and interference with other preparations you are taking, consult your doctor.
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FAQ
Can I have malaise after ashwaganda?
Mood malaise after ashwaganda is one of the symptoms of excessive intake (above 1000 mg of extract per day) or poor tolerance to this adaptogen. If you feel unwell after ashwaganda, discontinue its use.
Is ashwagandha a drug?
No, ashwagandha is not a drug because it does not contain substances that cause addiction, it does not intoxicate and it does not lower the sensitivity of the central nervous system. Ashwagandha is not classified as a narcotic.
Ashwagandha - what to combine with?
Ashwagandha is worth combining with other adaptogenic plants, such as rhodiola montana, ginseng, cordyceps, gotu-cola or astragalus. These combinations work synergistically to support the building of stress resistance and add vitality.
Can Rhodiola be combined with ashwagandha?
Yes, it is possible to combine Rhodiola Rosea (mountain rhodiola) with ashwagandha. Extracts from these plants are often found together in herbal supplements for stress. They can work synergistically to help the body adapt to stress and maintain balance. It is safest to use 250 to 1000 mg of ashwagandha and 250-600 mg of rhodiola.
However, strictly follow the manufacturer's recommended daily servings, as each formula may have different standardisation and bioactive ingredient content.
Does ashwagandha cause harm?
Ashwagandha is harmful if taken in excessive amounts (>1000 mg of extract and >3 g of root per day) and for too long a period of time (more than 12 weeks). Failure to follow the manufacturer's recommendations can result in digestive problems, headaches and even damage to the liver.
Is it possible to combine ginseng with ashwagandha?
It is possible to combine ginseng with ashwagandha and it is quite a popular combination in dietary supplements. However, caution should be exercised and a doctor should be consulted before consuming such a combination, as both plants are adaptogens and have powerful effects on the human body.
Does ashwagandha work for neurosis?
Yes, ashwagandha works for neurosis (or more correctly, anxiety disorders), and the best anti-anxiety, calming and stress-reducing effects come from taking 250-600 mg of the extract for 8-12 weeks.
Sources
See all
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Editorials
Meet the team
Mar 27
Ashwagandha affects thyroid hormone levels. Find out if you can use it.
Mar 26
See how mountain pintail can affect your wellbeing.
Mar 26
Check out the opinions of doctors and other professionals about ashwagandha. Also find out what people on the forum think about it.