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Withania somnifera - properties, how it works, what it helps + opinions

Withania somnifera (or ashwagandha) shows beneficial adaptogenic effects on the human body.

AuthorNina Wawryszuk

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Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

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Reviewed byJulia Skrajda

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Reviewed byJulia Skrajda

Clinical nutritionist

A clinical nutritionist, she works in the profession and creates personalised menus and recommendations for disease entities.

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Withania somnifera - properties, how it works, what it helps + opinions

10 July, 2024

Reviewed by06 December, 2023

Updated by08 December, 2023

Fact-checking04 December, 2023

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19 min

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For thousands of years, withania somnifera, also known as ashwagandha, has been used by practitioners in Eastern medicine for its support of stress resistance, improved sleep and even improved libido. If you're tempted to check out this exotic plant, find out what it can help you with and how to use it safely.

From this article you will learn:

What properties withania somnifera exhibits.
How much and how much it can help you.
How much and how to use it to feel the effects.
What the side effects of use may be.
Who should take it?
Who should not take withania somnifera.

See also:

Withania somnifera - what is this plant?

Withania somnifera is the plant also known by the names: ashwagadha, Indian ginseng, and withania somnifera. It is commonly used in Ayurveda - traditional Indian medicine for : stress relief,

among other things.

improve sleep quality, strengthen the body, support health and well-being .

It belongs to adaptogens, a group of plants with specific effects on the human body. Adaptogens induce physiological, morphological and biochemical changes in the body, exhibit antioxidant, tonic effects and help restore a state of homeostasis (balance) .

Adaptogens, which also include rhodiola rosea, membranous astragalus or cordiaceps are non-toxic and safe for most people .

Active substances

The compounds in Withania somnifera that are responsible for its health benefits are :

alkaloids (e.g. vitanin, somniferin, anaferin),
vitanolides, or steroidal lactones (e.g. vitanoline a, vitanolides a-y),
vitanolid glycosides (e.g. sitoindosides, vitanosides),
flavonoids,
saponins,
coumarins,

Ashwagandha contains the most structurally diverse set of valuable vitanolides of all plants, which translates into its unique effects on the human body.

Julia SkrajdaDietitian

Withania somnifera - properties

Sleptomania has adaptogenic properties - it increases resistance to stress and its negative effects, has antioxidant and tonic effects, helps maintain a sense of well-being and supports healthy sleep. It restores balance in the body and is a helpful support in the treatment of certain ailments .

This plant is one of the most studied adaptogens. Many scientific papers have examined its effects on physical and mental health. Results to date suggest that, in some individuals, it can be a helpful support for daily functioning as well as the treatment of many ailments .

withania somnifera can help with :

Stress, anxiety and mental tension. Vitania osprey is known for its anti-anxiety effects, relieving stress and its negative effects on the body. It lowers cortisol (the so-called stress hormone) and supports mental health.
Sleep disorders. Systematic intake of this plant can improve the quality of sleep, by making it easier to fall asleep, calmer and increasing nighttime rest time.
Self-esteem. By reducing stress and improving quality of sleep it positively affects mood and motivation.
Mind fitness. Regular supplementation can improve memory and concentration, positively affecting mental performance.
Fatigue. Withania somnifera may reduce feelings of fatigue and add energy. This can be linked to improved sleep quality - when you are sleepy, you have more desire to perform.
Regeneration of the body. Supports post-workout muscle recovery.
Improves immune function. Supports immune system function.
Antioxidation of the body. Eliminates harmful free radicals, reduces oxidative stress and reduces the negative consequences of their action.
Fertility. Increases sperm motility and improves semen quality.
Hormones. Increases testosterone levels in infertile men. Increases levels of thyroid hormones T3 and T4, so may support treatment of thyroid insufficiency.
Libido. Ashwagandha may help treat sexual dysfunction in women.
Cholesterol. Ashwagandha lowers 'bad' LDL cholesterol.
Pain relief. Reduces pain during chemotherapy and in osteoarthritis.
Conditioning. Supports the body's performance, especially in athletes doing endurance training, as it increases the aerobic ceiling.

Dosing of Withania somnifera

Dosage of Withania somnifera depends on the manufacturer and form of the preparation. However, the most common use is:

300 to 500 mg of extract per day for capsules or tablets,
up to 3 g of powdered root,
1 to 2 tablespoons (5 to 7 g) of tea made from the root,

Various daily portions of Withania somnifera have been used in research studies, with a common regimen being 300 mg of extract twice daily . Adjust the form and dosage to your preference and watch how you feel.

For improved sleep quality, stress reduction and tranquillity, 500 mg per night is recommended, while when it comes to muscle recovery and improved performance a 2 × 300 mg regimen will actually work.

Julia SkrajdaDietitian

If we are concerned about improving fertility in men and sperm quality, regular teas and infusions of the root work best - adds clinical nutritionist.

Is it possible to overdose on Withania somnifera?

Yes, it is possible to lead to an overdose. This is usually the result of using too much Withania somnifera, not in accordance with the manufacturer's recommendations. Scientists have used various doses (as high as 5000 mg) and forms (extracts, infusions) of this plant in their studies, but under controlled conditions.

Based on scientific work, it is considered that daily not to exceed 1,000 mg of extract and 3 g of powdered vitania periwinkle root . In using this adaptogen, regularity is key, rather than a high daily dose. You can take 800 mg every few days and you will achieve less benefit than someone using 300 mg but every day for 12 weeks.

Important

Withania somnifera is becoming increasingly popular, so many manufacturers are adding it to multi-ingredient formulations, such as for sleep, stress or vitality, and to so-called functional drinks. Sometimes it's a modest addition, but pay attention to what you're using so you don't unknowingly end up with an excess.

How long can Withania somnifera be used?

Withania somnifera can be safely used for up to 12 weeks, followed by a minimum 4-week break. There is no reliable data on chronic intake of this plant, so at this point it is considered "probably safe for humans" when used daily for 3 months .

You may encounter information that taking a break is unnecessary, however, there are no scientific studies that have documented the effects of chronic use of Withania somnifera . Don't be a self-proclaimed 'guinea pig', and for a 4-week break try other adaptogens, such as rhodiola rosea, cordyceps, maca or Chinese citronella.

Contraindications to the use of Withania somnifera

Withania somnifera should not be used :

pregnant and breastfeeding women,
persons under 18 years of age,
patients with autoimmune diseases, including thyroid disease, multiple sclerosis, type I diabetes, rheumatoid arthritis,
patients with bleeding disorders, gastric ulcers,
persons planning surgery,

Do not take Withania somnifera preparations if you are concurrently using :

blood-thinning medicines,
medications used to treat the thyroid gland,
medications that suppress the immune system,
medications used to treat depression and anxiety,
medications for high blood pressure,
sleep medicines,
herbal preparations that cause drowsiness (e.g. St. John's wort, valerian, methystine pepper).
herbal preparations that cause drowsiness.

Consult your doctor if in doubt and you want to try Withania somnifera.

Is Withania somnifera good for children?

There are no scientific studies that test what effect consuming ashwagandha has on children. We do not know if or how it affects their development, emotions and behaviour - for this reason, it is not recommended to give adaptogens to children.

Let's not kid ourselves - it is not an essential, irreplaceable plant for various ailments. If your child is restless, has trouble sleeping or is overtired, consult your doctor instead of giving them Withania somnifera.

If your child is restless, has trouble sleeping or is overtired, consult your doctor instead of giving them Withania somnifera.

Withania somnifera - side effects

The use of ashwagandha may cause side effects :

abdominal pain,
vomiting,
nausea,
diarrhoea,
headache,
rash,
bad mood,
insomnia, insomnia, nightmares,
thyroid dysfunction,

To avoid side effects, check for contraindications to use and for interactions between your medication and other dietary supplements you are taking. If in doubt, advise your doctor.

How to choose the best withania somnifera product?

To choose the best Withania somnifera (ashwagandha) product pay attention to:

Standardisation. Determines whether there is an active ingredient in a particular herbal product and in what quantity. Withania somnifera supplements should be standardised for vitanolides content. Ideally, there should be a minimum of 2.5% (a maximum of 10% - you won't buy more in Poland).
DER ( Drug Extract Ratio). Indicates how much plant material was used to produce one part of the extract obtained. E.g. DER 10:1 means that 10 g yielded 1 g of extract. The higher the DER, the stronger the extract.
Certificates. Trusted producers are happy to boast stamps attesting to good production practices, sustainable cultivation or laboratory testing.
Convenience. Consider what form will be most convenient - drops, capsules, tablets, infusion. Will you want to make a drink every day? Do you have a problem swallowing tablets?

Who can withania somnifera help?

The use of Withania somnifera is recommended for everyone:

experiencing stress, tension, anxiety,
fatigued,
with moderate sleep problems,
wanting to improve memory and concentration,
physically active,
women experiencing sexual dysfunction or menopause,
men with libido and fertility problems,
who want to feel a natural surge of energy and add vitality,

Famous moon milk

In Indian medicine, to achieve harmony of body, soul and mind, a nutritious diet and good sleep are fundamental. A recommended drink that is beneficial for a good night's rest is moon milk. Will you try it?

Ingredients for 1 serving:

milk or vegetable drink - 200 g
natural honey - 1 tbsp (approx. 20 g)
ashwagandha root powder - incomplete teaspoon (up to 3 g)
nutmeg - 1 pinch
ground cinnamon - 1 pinch
curcuma - 1 pinch

Making:

Heat the milk or vegetable drink over a low heat.
Add to the warm milk or vegetable drink.
Add all the ingredients except the honey to the warm liquid.
Stir the ingredients well, preferably with a whisk.
Add the honey, but do not boil the liquid.
Decorate or add other ingredients as desired, e.g. dried flowers, fruit.

See also:

Analysis of dietary supplements:

Summary

Withania somnifera is an adaptogenic plant used in Eastern medicine - Ayurveda. It is better known by the names ashwagandha and ashwagandha and withania somnifera.
Thanks to the bioactive compounds it contains (including vitanolides), it has an adaptogenic effect, i.e. it supports the body in coping with stress and restoring physical and mental balance.
Vitanolid improves mood, proper sleep, helps with stress, anxiety and tension, influences testosterone and thyroid hormone levels, supports male fertility, libido, helps with recovery and improves fitness.
The main contraindications to its use are age under 18, pregnancy, lactation, use of specific category drugs and certain diseases.
The usual use of this plant is 300-500 mg of extract or 3 g of Withania somnifera powder per day.
The use of this plant is safe for 3 months, then it is recommended to take a break.

FAQ

How does Withania somnifera work?

Withania somnifera acts adaptogenically in that it increases the body's resistance to stress and negative environmental factors through the bioactive substances it contains (mainly vitanolides). It acts antioxidant, tonic, supports healthy sleep and improves mood.

This adaptogen supports sexual health, improves male fertility, reduces the severity of some menopausal symptoms, and is a useful addition to the diet of performance athletes as well as those weight training.

How to pronounce and spell ashwagandha correctly?

On the internet you will find many incorrect (as well as funny) spellings of this plant, e.g.: ashpaganda, asheaganda, ashfaganda, ashwafanda. The correct spelling is ashwagandha, and is pronounced ash-wa-gan-duh.

How to use withania somnifera.

To feel the benefits of consuming this adaptogen, take a high-quality extract with a minimum of 2.5% vitanolides and use it daily for 8-12 weeks. You can feel the first effects of use even after 4 weeks.

Does ashwagandha make you sleepy?

No, ashwagandha (Withania somnifera) does not have a sleep-inducing effect because it does not have an ad hoc effect (the effects are visible after 4-8 weeks of daily use) and it does not contain substances that would affect sleepiness (therefore it can be used at any time of the day). Ashwagandha, after prolonged use, supports falling asleep and may improve sleep quality.

Is ashwagandha safe?

Yes, ashwagandha (Withania somnifera) is safe - it is one of the best studied adaptogens that is well tolerated by most people and rarely causes side effects. Typically, ashwagandha harms people who use excessive amounts of it.

Vegetable ashwagandha - where to buy?

You can buy Withania somnifera (ashwagandha) stationary, e.g. in good herbal shops, health food shops, pharmacies and online. When shopping, check the quality of the product - a good ashwagandha preparation should contain a standardised percentage of vitanolides.

How many tablets of ashwagandha per day?

How many tablets (capsules, powder) of ashwagandha to take per day depends on the specific manufacturer, so always take it as it is written on the packaging. Preparations with this adaptogen have different forms and daily portions.

Does withania somnifera work?

Yes, Withania somnifera has antioxidant and tonic effects, supports mental function, healthy sleep, reduces fatigue and reduces the negative effects of stress on mental and physical health. In addition, it has beneficial effects on male fertility, libido and reduces sexual dysfunction in women.

Sources

See all

A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults-PubMed. (n.d.). Retrieved November 25, 2023, from https://pubmed.ncbi.nlm.nih.gov/23439798/

Abdelwahed, M. T., Hegazy, M. A., & Mohamed, E. H. (2023). Major biochemical constituents of Withania somnifera (ashwagandha) extract: A review of chemical analysis. Reviews in Analytical Chemistry, 42(1). https://doi.org/10.1515/revac-2022-0055

Ahmad, M. K., Mahdi, A. A., Shukla, K. K., Islam, N., Rajender, S., Madhukar, D., Shankhwar, S. N., & Ahmad, S. (2010). Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Fertility and Sterility, 94(3), 989-996. https://doi.org/10.1016/j.fertnstert.2009.04.046

Ahmed, W., Mofed, D., Zekri, A.-R., El-Sayed, N., Rahouma, M., & Sabet, S. (2018). Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line. The Journal of International Medical Research, 46(4), 1358-1369. https://doi.org/10.1177/0300060517752022

Ajgaonkar, A., Jain, M., & Debnath, K. (n.d.). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus, 14(10), e30787. https://doi.org/10.7759/cureus.30787

Ambiye, V. R., Langade, D., Dongre, S., Aptikar, P., Kulkarni, M., & Dongre, A. (2013). Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evidence-Based Complementary and Alternative Medicine: eCAM, 2013, 571420. https://doi.org/10.1155/2013/571420

Anwer, T., Sharma, M., Pillai, K. K., & Iqbal, M. (2008). Effect of Withania somnifera on insulin sensitivity in non-insulin-dependent diabetes mellitus rats. Basic & Clinical Pharmacology & Toxicology, 102(6), 498-503. https://doi.org/10.1111/j.1742-7843.2008.00223.x

Ashwagandha. (2012). In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.ncbi.nlm.nih.gov/books/NBK548536/

Björnsson, H. K., Björnsson, E. S., Avula, B., Khan, I. A., Jonasson, J. G., Ghabril, M., Hayashi, P. H., & Navarro, V. (2020). Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver International, 40(4), 825-829. https://doi.org/10.1111/liv.14393

Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. Indian Journal of Psychological Medicine, 34(3), 255-262. https://doi.org/10.4103/0253-7176.106022

Chauhan, S., Srivastava, M. K., & Pathak, A. K. (2022). Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial. Health Science Reports, 5(4), e741. https://doi.org/10.1002/hsr2.741

Cheah, K. L., Norhayati, M. N., Husniati Yaacob, L., & Abdul Rahman, R. (2021). Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PloS One, 16(9), e0257843. https://doi.org/10.1371/journal.pone.0257843

Choudhary, B., Shetty, A., & Langade, D. G. (2015). Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu, 36(1), 63-68. https://doi.org/10.4103/0974-8520.169002

Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract. Journal of Evidence-based Complementary & Alternative Medicine, 22(1), 96-106. https://doi.org/10.1177/2156587216641830

Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974. PLOS ONE, 4(8), e6628. https://doi.org/10.1371/journal.pone.0006628

Dhama, P., Ding, X., & Sharma, A. (2023). Exploring phytochemicals of Withania somnifera from different vicinities for functional foods. Journal of Future Foods, 3(3), 278-287. https://doi.org/10.1016/j.jfutfo.2023.02.010

Dongre, S., Langade, D., & Bhattacharyya, S. (2015a). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. BioMed Research International, 2015, e284154. https://doi.org/10.1155/2015/284154

Dongre, S., Langade, D., & Bhattacharyya, S. (2015b). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. BioMed Research International, 2015, 284154. https://doi.org/10.1155/2015/284154

Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial-ScienceDirect. (n.d.). Retrieved November 17, 2023, from https://www.sciencedirect.com/science/article/abs/pii/S1558787822000326

Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults-PubMed. (n.d.). Retrieved November 25, 2023, from https://pubmed.ncbi.nlm.nih.gov/26730141/

Jędruszczak, P., Zdun, S., Walczak, K., Wesołowska, Z., & Gaweł, W. (2023). Ashwagandha (Withania somnifera) - influence on sleep: Review. Quality in Sport, 9(1), Article 1. https://doi.org/10.12775/QS.2023.09.01.005

Kamal, H. I., Patel, K., Brdak, A., Heffernan, J., & Ahmad, N. (n.d.). Ashwagandha as a Unique Cause of Thyrotoxicosis Presenting With Supraventricular Tachycardia. Cureus, 14(3), e23494. https://doi.org/10.7759/cureus.23494

Kumar, A., & Kalonia, H. (2008). Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism. Indian Journal of Pharmaceutical Sciences, 70(6), 806-810. https://doi.org/10.4103/0250-474X.49130

Kumar, R., Gupta, K., Saharia, K., Pradhan, D., & Subramaniam, J. R. (2013). Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Annals of Neurosciences, 20(1), 13-16. https://doi.org/10.5214/ans.0972.7531.200106

Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (n.d.). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus, 11(9), e5797. https://doi.org/10.7759/cureus.5797

Langade, D., Thakare, V., Kanchi, S., & Kelgane, S. (2021). Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of Ethnopharmacology, 264, 113276. https://doi.org/10.1016/j.jep.2020.113276

Lopresti, A. L., Drummond, P. D., & Smith, S. J. (2019). A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. American Journal of Men's Health, 13(2), 1557988319835985. https://doi.org/10.1177/1557988319835985

Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2022). Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: A systematic review of human trials. Nutritional Neuroscience, 25(8), 1704-1730. https://doi.org/10.1080/1028415X.2021.1892253

Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186

Lubarska, M., Halasinski, P., Hryhorowicz, S., Mahadea, D. S., Łykowska-Szuber, L., Eder, P., Dobrowolska, A., & Krela-Kaźmierczak, I. (2023). Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. International Journal of Environmental Research and Public Health, 20(5), 3921. https://doi.org/10.3390/ijerph20053921

Mh, M., E, M., M, B., Rm, C., & J, P. (2009). Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules (Basel, Switzerland), 14(7). https://doi.org/10.3390/molecules14072373

Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057

Murray, M. (2022). Ashwagandha Research Analysis. https://examine.com/supplements/ashwagandha/

Nasimi Doost Azgomi, R., Zomorrodi, A., Nazemyieh, H., Fazljou, S. M. B., Sadeghi Bazargani, H., Nejatbakhsh, F., Moini Jazani, A., & Ahmadi AsrBadr, Y. (2018). Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence. BioMed Research International, 2018, e4076430. https://doi.org/10.1155/2018/4076430

Panda, S., & Kar, A. (1998). Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. The Journal of Pharmacy and Pharmacology, 50(9), 1065-1068. https://doi.org/10.1111/j.2042-7158.1998.tb06923.x

Pingali, U., Pilli, R., Fatima, N., & Fatima, N. (2014). Effect of Standardized Aqueous Extract of Withania Somniferaon Tests of Cognitive and Psychomotor Performance in Healthy Human Participants. Pharmacognosy Research, 6(1), 12-18. https://doi.org/10.4103/0974-8490.122912

Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., & Kala Kumar, B. (2020). Adaptogenic and Immunomodulatory Activity of Ashwagandha Root Extract: An Experimental Study in an Equine Model. Frontiers in Veterinary Science, 7, 541112. https://doi.org/10.3389/fvets.2020.541112

Remenapp, A., Coyle, K., Orange, T., Lynch, T., Hooper, D., Hooper, S., Conway, K., & Hausenblas, H. A. (2022). Efficacy of Withania somnifera supplementation on adult's cognition and mood. Journal of Ayurveda and Integrative Medicine, 13(2), 100510. https://doi.org/10.1016/j.jaim.2021.08.003

Sahin, K., Orhan, C., Akdemir, F., Tuzcu, M., Gencoglu, H., Sahin, N., Turk, G., Yilmaz, I., Ozercan, I. H., & Juturu, V. (2016). Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats. BMC Complementary and Alternative Medicine, 16(1), 318. https://doi.org/10.1186/s12906-016-1303-x

Salve, J., Pate, S., Debnath, K., Langade, D., Salve, J., Pate, S., Debnath, K., & Langade, D. G. (2019). Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 11(12). https://doi.org/10.7759/cureus.6466

Sarris, J. (2018). Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytotherapy Research, 32(7), 1147-1162. https://doi.org/10.1002/ptr.6055

Sharma, A. K., Basu, I., & Singh, S. (2018). Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial. The Journal of Alternative and Complementary Medicine, 24(3), 243-248. https://doi.org/10.1089/acm.2017.0183

Singh, N., Bhalla, M., Jager, P. de, & Gilca, M. (2011). An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), Article 5S. https://doi.org/10.4314/ajtcam.v8i5S.9

Singh, R. H., Narsimhamurthy, K., & Singh, G. (2008). Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology, 9(6), 369-374. https://doi.org/10.1007/s10522-008-9185-z

Srivastava, A. N., Ahmad, R., & Khan, M. A. (2016). Evaluation and Comparison of the In Vitro Cytotoxic Activity of Withania somnifera Methanolic and Ethanolic Extracts against MDA-MB-231 and Vero Cell Lines. Scientia Pharmaceutica, 84(1), Article 1. https://doi.org/10.3797/scipharm.1507-13

Tandon, N., & Yadav, S. S. (2020). Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. Journal of Ethnopharmacology, 255, 112768. https://doi.org/10.1016/j.jep.2020.112768

Tharakan, A., Shukla, H., Benny, I. R., Tharakan, M., George, L., & Koshy, S. (2021). Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Journal of Clinical Medicine, 10(16), 3644. https://doi.org/10.3390/jcm10163644

Tiwari, S., Gupta, S. K., & Pathak, A. K. (2021). A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Journal of Ethnopharmacology, 272, 113929. https://doi.org/10.1016/j.jep.2021.113929

Udayakumar, R., Kasthurirengan, S., Mariashibu, T. S., Rajesh, M., Anbazhagan, V. R., Kim, S. C., Ganapathi, A., & Choi, C. W. (2009). Hypoglycaemic and Hypolipidaemic Effects of Withania somnifera Root and Leaf Extracts on Alloxan-Induced Diabetic Rats. International Journal of Molecular Sciences, 10(5), 2367-2382. https://doi.org/10.3390/ijms10052367

Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., & Deshpande, M. (2010). Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: Ashwagandha. Central Nervous System Agents in Medicinal Chemistry, 10(3), 238-246. https://doi.org/10.2174/1871524911006030238

Verma, N., Gupta, S. K., Tiwari, S., & Mishra, A. K. (2021). Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, study in Healthy Volunteers. Complementary Therapies in Medicine, 57, 102642. https://doi.org/10.1016/j.ctim.2020.102642

Wang, J., Zhang, H., Kaul, A., Li, K., Priyandoko, D., Kaul, S. C., & Wadhwa, R. (2021). Effect of Ashwagandha Withanolides on Muscle Cell Differentiation. Biomolecules, 11(10), 1454. https://doi.org/10.3390/biom11101454

Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomised controlled trial. Journal of the International Society of Sports Nutrition, 12(1), 43. https://doi.org/10.1186/s12970-015-0104-9

Wei, Z., Li, T., Kuang, H., Su, H., & Wang, Q. (2020). Pharmacological Effects of Withanolides. Biomedical Journal of Scientific & Technical Research, 25(3), 19243-19248. https://doi.org/10.26717/BJSTR.2020.25.004218

White, P. T., Subramanian, C., Motiwala, H. F., & Cohen, M. S. (2016). Natural Withanolides in the Treatment of Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases, 928, 329-373. https://doi.org/10.1007/978-3-319-41334-1_14

Wongtrakul, J., Thongtan, T., Kumrapich, B., Saisawang, C., & Ketterman, A. J. (2021). Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model. Heliyon, 7(10), e08172. https://doi.org/10.1016/j.heliyon.2021.e08172

Dietary Supplements Team-Government Sanitary Inspectorate-Gov.co.uk portal. (n.d.). Chief Sanitary Inspectorate. Downloaded 25 March 2023, from https://www.gov.pl/web/gis/zespol-do-spraw-suplementow-diety

Ziegenfuss, T. N., Kedia, A. W., Sandrock, J. E., Raub, B. J., Kerksick, C. M., & Lopez, H. L. (2018). Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial. Nutrients, 10(11), Article 11. https://doi.org/10.3390/nu10111807

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