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KSM-66 - the best and purest ashwagandha extract

Pure as a tear? From now on, say: pure as ... KSM-66 extract - Experience the best formula on the market.

Nina Wawryszuk - AuthorAuthorNina Wawryszuk
Nina Wawryszuk - Author
AuthorNina Wawryszuk
Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

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Ilona Bush - Reviewed byReviewed byIlona Bush
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Ilona Bush - Reviewed by
Reviewed byIlona Bush
Master of Pharmacy

Ilona Krzak obtained her Master of Pharmacy degree from the Medical University of Wrocław. She did her internship in a hospital pharmacy and in the pharmaceutical industry. She is currently working in the profession and also runs an educational profile on Instagram: @pani_z_apteki

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Bartholomew Turczynski - Edited by
Edited byBartholomew Turczynski
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Bartłomiej Turczyński is the editor-in-chief of Natu.Care. He is responsible for the quality of the content created on Natu.Care, among others, and ensures that all articles are based on sound scientific research and consulted with industry specialists.

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Fact-checkingEmilia Moskal
Natu.Care Editor

Emilia Moskal specialises in medical and psychological texts, including content for medical entities. She is a fan of simple language and reader-friendly communication. At Natu.Care, she writes educational articles.

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KSM-66 - the best and purest ashwagandha extract
29 April, 2024
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There has been 14 years of research and development to perfect the KSM-66 extract of ashwagandha. Ixoreal squeezed all the potential out of this plant so that when you supplement, you experience the full power of ayurveda, instead of... sterile disappointment.

It is difficult to find another equally well-documented process for the production of ashwagandha extract and an impressive amount of in-house research. The creators of KSM-66 have sweated in production so that you don't have to, browsing through 26,354 formulations to choose from.

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From this article you will learn:

  • What ashwagandha KSM-66 is.
  • .
  • Why it is the best form of ashwagandha.
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  • What are the benefits of using KSM-66.
  • .

See also:

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Ashwagadha (or Indian ginseng, sparkle plantwithania somnifera) is a plant popular in Eastern medicine - Ayurveda. It belongs to the group adaptogens, which are plants that induce physiological, morphological or biochemical changes in the human bodyand

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Ashwagandha is a known adaptogen as it increases resistance to physical, chemical and biological stressors, builds energy and overall vitality.
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Ilona Krzak.

Ilona Krzak Master of Pharmacy

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This plant is the best studied adaptogen, and scientific findings suggest that its use is safe and well tolerated by most people. Ashwagandha is a popular choice for people who are overtired, stressed, have problems with tension, anxiety and experience sleep disordersand.

KSM-66 - what is it?

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KSM-66 is a patented extract of the root ashwagandha with a high concentration of 5% vitanolides. The extract is produced using a unique proprietary extraction process based on 'green chemistry' principles, without the use of alcohol or any other chemical solventand.

This is pure, high-quality ashwagandha with good bioavailability, which means your body can extract more health and mind benefits from the extract. The positive properties of KSM-66 have been tested in 24 clinical trials, with results suggesting that regular intake of supplements with this extract benefits mood, sleep and healthand.

Green chemistry - what does it mean?

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Green chemistry is a concept consisting of 12 principles that involve designing and carrying out chemical processes in such a way as to reduce the use and generation of harmful substances 

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Why choose KSM-66?

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It is worth choosing formulations with the KSM-66 formula because this way you are sure of what you are consuming and in what quantity. Some products with ashwa are tempting. However, when you look at the ingredients, it turns out to be siano - e.g. powdered root, no standardisation.... When choosing the best ashwagandha for you, choose products that are likely to work.

What makes the case for choosing KSM-66?

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Patented formula

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Having a patented formula can indicate that a product is innovative, differentiates it from others on the market and may provide additional benefits over other similar productsand.

The Ixoreal company - the creator of KSM-66 - is the only producer of ashwagandha in the world with its own farms, production facilities, testing laboratories, research centre and distribution, and it took 14 years to develop this formula .

Ashwagandha root extract is extracted using a unique proprietary process based on 'green chemistry' principles, making the formula pure and free of unnecessary additives. In short, you won't find another raw material like it.

High-quality extract

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KSM-66 is an ashwagandha root extract with a high concentration of 5% vitanolides and the most bioavailable, full spectrum on the market. By keeping all the natural constituents of this plant in 'original balance', you can realise 100% of the potential of vitanolides and feel its positive effects on your body.

The balance of compounds in ashwaganda refers to the proportions and ratios between the bioactive components that are present in it. The plant contains a variety of compounds, including alkaloids, vitanolides, sterols and lactonesand.

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The balance of compounds is important because different components can act synergistically or complementarily, allowing the plant to exhibit a broad spectrum of biological activities.
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Ilona Krzak.

Ilona Krzak Master of Pharmacy

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It is important to use appropriate methods of ashwagandha extraction and processing to maintain this balance and extract the full potential of the active substances - adds pharmacist.

Scientific research

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Ixoreal is an industry leader in clinical and basic research into the efficacy of ashwagandha. It collaborates with academic and research institutes. All clinical trials conducted by the company follow 'gold standards' - randomised, double-blinded and placebo-controlled.

The company boasts 24 scientific studies using KSM-66, the results of which suggest its comprehensive positive effects in study participants.

Vitanolides content

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Preparations with the KSM-66 formula contain a high percentage of vitanolides. They are responsible for most of the health and mental benefits. It contains 5% concentration of vitanolides measured by HPLC ( High-Performance Liquid Chromatography).

HPLC is an advanced chromatographic technique that is widely used in analytical, scientific and industrial research. It is a method that is used for the separation, identification and quantification of chemicals in samplesand.

Vitanolides found in plants are organic chemical compounds that have high biological activity. This means that they can have antimicrobial, antiviral, antioxidant and anti-inflammatoryand, among other effects.

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Ashwaghanda root contains the most vitanolides and is the best source of them.
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Ilona Krzak.

Ilona Krzak Master of Pharmacy

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Studies have shown that extracts of withania somnifera exhibit numerous therapeutic effects, including reduction of inflammationoxidative stress, improvement of memory and cognitive function.

Certificates

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KSM-66 has an impressive number of certifications that prove that the raw material as well as its production process is of high quality. The formula and its production have passed the most extensive inspections and safety assessments in the industry.

Certifications that KSM-66 holds include:

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  • GMP good manufacturing practices,
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  • 100% USDA Organic,
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  • Non-GMO,
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  • Gluten Free,
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  • BSCG-drug free,
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  • Kosher, Halal,
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  • HACCP,
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  • GRAS,
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  • Vegan,
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Results of scientific studies

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Research conducted by Ixoreal using KSM-66 tested how regular supplementation of various daily servings of this formula affects several areas of health.

Most important information about the study:

  • The study lasted 8-10 weeks.
    • The participants were given the following information.
    • Participants were typically given 600 mg of the extract divided into 2 daily servings or a placebo.
    • Participants were given the following.
    • Participants from different age groups were included in the studies.
    • Two studies were conducted.
    • Two studies were conducted with animals, one using an in vitro method.
    • .

    Analysis of studies involving humans

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    The results were within normal limits.

    Health area studied

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    Results

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    Daily intake of KSM-66 and duration of study

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    .

    Safety of use and well-being

    The consumption of KSM-66 for 8 weeks is safe, well tolerated and free of adverse effects in healthy men and women. Physical, haematological and biochemical parameters measured in the participants were within normal limits.

    600 mg of extract administered in 2 portions daily for 8 weeks

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    Stress, mental tension and anxiety

    Reduce cortisol levels, improve resistance to stress, improve well-being.

    Reduce cortisol levels, improve resistance to stress, improve well-being.

    600 mg extract administered in 2 portions daily for 8 weeks

    Memory and cognitive function

    Improvement of both immediate and general memory, support of executive function, concentration and speed of information processing.

    600 mg of extract administered in 2 portions per day for 8 weeks

    Sleep quality

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    Reduction in time to fall asleep, subjective improvement in quality of sleep, reduction in pre-sleep tension.

    600 mg of extract administered in 2 portions daily for 10 weeks

    Men's sexual health

    Subjective assessment of sexual health improvement as assessed by desire and libido parameters in subjects.

    600 mg of extract administered in 2 doses daily for 8 weeks

    Female sexual health

    There was a subjective improvement in sexual health in women with sexual dysfunction as assessed by the parameters: desire, arousal, lubrication, orgasm, sexual satisfaction and degree of pain.

    600 mg of extract administered in 2 doses daily for 8 weeks

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    Menopausal symptoms during menopause

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    Reduce some of the symptoms that accompany menopause - hot flashes, night sweats, memory problems and mood swings.

    Reduce some of the symptoms that accompany menopause - hot flashes, night sweats, memory problems and mood swings.

    600 mg of extract given in 2 doses daily for 8 weeks

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    Effect on testosterone concentrations

    Increase in testosterone concentration

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    675 mg of extract administered in 2 servings daily for 8 weeks

    Increase in testosterone levels.

    Regeneration and increase in muscle mass

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    Improve strength performance, increase muscle mass and shorten post-workout recovery.

    Improve strength performance, increase muscle mass and shorten post-workout recovery.

    600 mg of extract administered in 2 servings daily for 8 weeks

    Effect on hormone levels thyroid hormones in people with low levels

    Increase concentrations of the hormones TSH, FT-3, FT-4.

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    600 mg of extract administered in 2 portions daily for 8 weeks

    Strength and performance

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    Increase aerobic ceiling and improve endurance

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    600 mg of extract administered in 2 portions daily for 8 weeks

    Studies involving animals

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    Horses

    The effects of ashwagandha on stress and overall health in horses were studied. Twenty-four Kathiawari animals were divided into 2 groups - one consuming normal feed and the other consuming feed with different amounts of ashwagandha root extractand.

    It is worth adding that horses of this breed are used as pack animals (carrying goods) and in equestrianism. This exposes them to physical as well as psychological stress.

    After 3 weeks, horses consuming feed with the extract showed a reduction in concentrations of  cortisol, triglycerides and epinephrine (adrenaline), among others.

    Dogs

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    In this 4-week study, 24 dogs experiencing stress and anxiety received either placebo or 15 mg/kg body weight of ashwagandha root extract daily. Outcome measures included urinary cortisol/creatine ratio, the Canine Behavioural Assessment and Research Questionnaire, the Canine Brief Pain Inventory (CBPI) pain scale and the Body Condition Score (BCS)and.

    The results suggest that taking ashwagandha root extract reduced symptoms related to stress, anxiety and worry, and pain severity. It was also associated with a statistically significant reduction in the urinary cortisol/creatine ratio.

    Take of Ashwagandha was well tolerated by all dogs and no adverse effects were reported.

    In vitro study

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    In an 'in glass' study, human HeLa cells were treated with different concentrations of ashwagandha root extract. The results showed an increase in telomerase (enzyme) activity, suggesting that KSM-66 has anti-ageing potentialand.

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    HeLa cells are the oldest cell culture derived from humans. It is the most widely used cell line in scientific research.
    .
    Ilona Krzak.

    Ilona Krzak Master of Pharmacy

    .
    .

    Telomerase activity is important because this enzyme is responsible for 'rebuilding' telomeres, the ends of DNA that naturally shorten during cell replication. If telomeres shorten too much, cells stop dividing properly, which is one aspect of the ageing processand.

    KSM-66 for... hair?

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    A recent study from 2023 tested the effects of ashwagandha KSM-66 on hair loss. Study participants were to apply topically 1-2 drops per day of aqueous ashwagandha root extract to the scalpand.

    After 75 days ashwagandha:

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    • significantly reduced hair loss,
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    • increased their density and thickness,
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    • improved hair growth,
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    Performed much better than the group of people in this study who applied a placebo to the scalp.

    Findings from the study on the effects of KSM-66

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    The researchers experienced beneficial effects from taking ashwagandha KSM-66 using 600 mg of the extract (divided into 2 daily servings) daily for 8 weeks. This is a valuable tip to stick to systematics and... be patient.

    According to research, taking KSM-66 extract of ashwagandhaand:

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    • reduces mental stress and tension,
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    • positively affects mood,
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    • improves memory and concentration,
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    • increases performance and endurance,
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    • enhances post-workout recovery,
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    • increases testosterone and thyroid hormones,
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    • relieves some symptoms of menopause,
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    • promotes sexual health in men and women,
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    • has antioxidant and tonic effects on the body,
    • .

    The consumption of ashwagandha KSM-66 is safe, well tolerated and free of adverse effects in healthy adults and animals.

    See also compositional analyses:

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    Who can benefit from the use of KSM-66?

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    Ashwagandha may be helpful for you if: 

    • you want to improve your memory and concentration,
    • .
    • you feel chronic fatigue,
    • .
    • you live with mental tension, 
    • .
    • you have problems falling asleep and relaxing,
    • you have problems sleeping,
    • and
    • you suffer from moderate sleep problems,
    • .
    • you want to improve sports performance - strength as well as endurance, 
    • .
    • you want to improve your sexual health,
    • .
    • you are in the difficult period of menopause,
    • .
    .

    Important

    Remember that even the purest extract will not help if your health problems are serious - for example, you suffer from insomnia, chronic fatigue or impaired thyroid function. Treat ashwagandha as a support, not the main source of treatment.

    Contraindications to use

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    The use of ashwagandha extract preparations is not suitable forand:

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      .
    • pregnant and breastfeeding women,
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    • persons under 18 years of age,
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    • patients with autoimmune diseases (including thyroid disease, rheumatoid arthritis, diabetes, multiple sclerosis),
    • .
    • persons with bleeding disorders and gastric ulcers,
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    • persons planning surgery,
    • .

    Also, ashwagandha should not be used with certain medications. Below is a list of medications and examples of popular preparations in Poland that belong to this group.

    Ashwagandha should not be combined with medications:

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    • blood-thinning drugs, e.g. Warfin, Pradaxa, Xarelto, Aspirin, Acard,
    • .
    • used in the treatment of disorders thyroid conditions, e.g. Letrox, Eurhyrox, Thyrozol,
    • .
    • inhibitors of the immune system, e.g. Metypred, Prograf, Equoral, Endoxan, Azathioprine, 
    • .
    • used for the treatment of depression or anxiety, e.g. Trittico, Dulsevia, Pramolan, Anafranil, Amitriptyline,
    • .
    • insomniacs, e.g. Zopiclone, Zolpidem, Trittico,
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    • for high blood pressure, e.g. Torsemed, Captopril, Prestarium, Telmizek, Hydrochlorothiazide,
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    • antidiabetics, e.g. Pioglitazone, Metformax, Amaryl, Forxiga, Jardiance.
    • .

    Ashwagandha KSM-66 - side effects

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    A number of studies confirm that ashwagandha is considered a safe supplement for most people when taken in an optimal daily dose and for no more than 12 weeks.

    However, Indian ginseng can cause various side effects in some people, and the most common areand:

    • abdominal pain,
    • .
    • nausea,
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    • vomiting,
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    • headache,
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    • insomnia, insomnia and nightmares,
    • .

    According to some scientific studies, the use of ashwagandha may adversely affect thyroid function and interfere with hormone production - particularly in the case of hypothyroidismand. Occasionally this plant may cause a skin rash and a doctor should be consulted.

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    Maintain in mind

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    Ashwagandha may cause falsely elevated digoxin levels in an immunoassayand. Digoxin is used in advanced heart failure, among other conditions. As you can see, it is a plant with a huge impact on the body and its functioning.

    See also:

    Summary

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    • KSM-66 is a high quality patented extract of ashwagandha developed by Ixoreal.
    • The extract is produced using a proprietary extraction process based on 'green chemistry' principles, without the use of alcohol or any other chemical solvent.
    • KSM-66 contains a 5% concentration of vitanolides, which are responsible for most of the beneficial properties of this plant.
    • The Ixoreal company cooperates with academic and research institutes. It has conducted 24 scientific studies according to the so-called gold standard, which suggest positive effects of KSM-66 on health and well-being.
    • Supplementation with ashwagandha extract can support mood, improve sleep quality, reduce tension and stress, affect hormone concentrations (including testosterone), increase performance and support post-workout recovery.
    • KSM-66 will be a helpful support in treating sexual dysfunction in women, improving libido and semen quality in men, and may reduce unpleasant symptoms of menopause.
    • Preparations with KSM-66 include information about the extract content on the packaging.
    • .

    FAQ

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    . Is KSM-66 legal?.

    Yes, ashwagandha KSM-66 is legal, i.e. the raw material (root extract) is authorised and can be used and sold by manufacturers of dietary supplements in products. KSM-66 has numerous certifications attesting to the high quality of production as well as the raw material itself.

    . What does the name KSM-66 mean?.

    The manufacturer has not disclosed what the name of the raw material KSM-66 means and it is not known what it refers to.

    . Can KSM-66 be given to children?.

    No, KSM-66 ashwagandha extract should not be given to children. The effects of this and other plants of the adaptogen group on people under the age of 18 are unknown. This age group has not been involved in scientific studies, so for safety reasons it is better not to give them ashwagandha.

    . Which ashwagandha is best?.

    The best ashwagandha should standardise on the percentage of vitanolides in a daily serving. This way, you know what quality ashwagandha is and how much you are realistically providing your body with the valuable vitanolides that are responsible for most of the properties of this adaptogenic plant.

    . What is DER?.

    DER ( Drug Extract Ratio), an indication of how much plant material was used to produce one part of the extract obtained, e.g. DER 10:1. The higher the DER, the stronger the extract.

    . Is ashwagandha KSM-66 addictive?.

    No, ashwagandha KSM-66 is not addictive as it contains no substances that cause mental or physical dependence. Ashwagandha is safe to use and generally well tolerated.

    . Does KSM-66 have a stimulant effect?.

    No, the extract from ashwagandha KSM-66 does not stimulate because it is not a stimulant and does not have an immediate effect, unlike, for example, caffeine or taurine. However, in some products KSM-66 may be present in the formulation with other stimulant ingredients, but the extract by itself does not act in this way.

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    Sources

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    . See all.

    A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults-PubMed. (n.d.). Retrieved November 21, 2023, from https://pubmed.ncbi.nlm.nih.gov/23439798/

    Ambiye, V. R., Langade, D., Dongre, S., Aptikar, P., Kulkarni, M., & Dongre, A. (2013). Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evidence-Based Complementary and Alternative Medicine: eCAM2013, 571420. https://doi.org/10.1155/2013/571420

    Chauhan, S., Srivastava, M. K., & Pathak, A. K. (2022). Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial. Health Science Reports5(4), e741. https://doi.org/10.1002/hsr2.741

    Choudhary, B., Shetty, A., & Langade, D. G. (2015). Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu36(1), 63-68. https://doi.org/10.4103/0974-8520.169002

    Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract. Journal of Evidence-based Complementary & Alternative Medicine22(1), 96-106. https://doi.org/10.1177/2156587216641830

    Dasgupta, A., Tso, G., & Wells, A. (2008). Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Journal of Clinical Laboratory Analysis, 22(4), 295-301. https://doi.org/10.1002/jcla.20252

    Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: A randomized controlled trial-ScienceDirect. (n.d.). Retrieved November 24, 2023, from https://www.sciencedirect.com/science/article/abs/pii/S1558787822000326

    Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults-PubMed. (n.d.). Retrieved November 21, 2023, from https://pubmed.ncbi.nlm.nih.gov/26730141/

    Elliott, G. C.. (2002). A brief guide to understanding patentability and the meaning of patents. Academic Medicine: Journal of the Association of American Medical Colleges77(12 Pt 2), 1309-1314. https://doi.org/10.1097/00001888-200212001-00002

    Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial-PMC. (n.d.). Retrieved November 21, 2023, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658772/

    Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., & Kala Kumar, B. (2020). Adaptogenic and Immunomodulatory Activity of Ashwagandha Root Extract: An Experimental Study in an Equine Model. Frontiers in Veterinary Science7, 541112. https://doi.org/10.3389/fvets.2020.541112

    Shear, R. H., & Kelley, T. E. (2003). A Researcher's Guide to Patents. Plant Physiology132(3), 1127-1130. https://doi.org/10.1104/pp.103.022301

    Tiwari, S., Gupta, S. K., & Pathak, A. K. (2021). A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Journal of Ethnopharmacology272, 113929. https://doi.org/10.1016/j.jep.2021.113929

    US EPA, O. (2013, February 12). Basics of Green Chemistry [Overviews and Factsheets]. https://www.epa.gov/greenchemistry/basics-green-chemistry

    Verma, N., Gupta, S. K., Tiwari, S., & Mishra, A. K. (2021). Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, study in Healthy Volunteers. Complementary Therapies in Medicine57, 102642. https://doi.org/10.1016/j.ctim.2020.102642

    Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. (2015). Examining the effect of Withania somnifera supplementation on muscle strength and recovery: A randomized controlled trial. Journal of the International Society of Sports Nutrition12(1), 43. https://doi.org/10.1186/s12970-015-0104-9

    Wongtrakul, J., Thongtan, T., Kumrapich, B., Saisawang, C., & Ketterman, A. J. (2021). Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model. Heliyon7(10), e08172. https://doi.org/10.1016/j.heliyon.2021.e08172

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Meet the team
Nina Wawryszuk - Author

Natu.Care Editor

Nina Wawryszuk specialises in sports supplementation, strength training and psychosomatics. On a daily basis, in addition to writing articles for Natu.Care, as a personal trainer she helps athletes improve their performance through training, diet and supplementation.

Ilona Bush - Reviewed by

Master of Pharmacy

Verified by an expert

Ilona Krzak obtained her Master of Pharmacy degree from the Medical University of Wrocław. She did her internship in a hospital pharmacy and in the pharmaceutical industry. She is currently working in the profession and also runs an educational profile on Instagram: @pani_z_apteki

Bartholomew Turczynski - Edited by

Editor-in-Chief

Bartłomiej Turczyński is the editor-in-chief of Natu.Care. He is responsible for the quality of the content created on Natu.Care, among others, and ensures that all articles are based on sound scientific research and consulted with industry specialists.

Emilia Moskal - Fact-checking

Natu.Care Editor

Emilia Moskal specialises in medical and psychological texts, including content for medical entities. She is a fan of simple language and reader-friendly communication. At Natu.Care, she writes educational articles.

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