Best ashwagandha? KSM-66 (benefits, side effects, dosage)

There has been 14 years of research and development to perfect the KSM-66 extract of ashwagandha. Ixoreal squeezed all the potential out of this plant so that when you supplement, you experience the full power of ayurveda, instead of... sterile disappointment.

It is difficult to find another equally well-documented process for the production of ashwagandha extract and an impressive amount of in-house research. The creators of KSM-66 have sweated in production so that you don't have to, browsing through 26,354 formulations to choose from.

See also:

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• Ashwagandha
• Ashwagandha - contraindications
• Ashwagandha - side effects
• What not to combine ashwagandha with
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• Ashwagandha - morning or night?
• Ashwagandha - when does it start working?
• Ashwagandha - dosage
• Indian ginseng
• Adaptogens

Ashwagandha - the most popular adaptogen

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Ashwagadha (or Indian ginseng, sparkle plant, withania somnifera) is a plant popular in Eastern medicine - Ayurveda. It belongs to the group adaptogens, which are plants that induce physiological, morphological or biochemical changes in the human bodyand. 

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This plant is the best studied adaptogen, and scientific findings suggest that its use is safe and well tolerated by most people. Ashwagandha is a popular choice for people who are overtired, stressed, have problems with tension, anxiety and experience sleep disordersand.

KSM-66 - what is it?

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KSM-66 is a patented extract of the root ashwagandha with a high concentration of 5% vitanolides. The extract is produced using a unique proprietary extraction process based on 'green chemistry' principles, without the use of alcohol or any other chemical solventand.

This is pure, high-quality ashwagandha with good bioavailability, which means your body can extract more health and mind benefits from the extract. The positive properties of KSM-66 have been tested in 24 clinical trials, with results suggesting that regular intake of supplements with this extract benefits mood, sleep and healthand.

Why choose KSM-66?

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It is worth choosing formulations with the KSM-66 formula because this way you are sure of what you are consuming and in what quantity. Some products with ashwa are tempting. However, when you look at the ingredients, it turns out to be siano - e.g. powdered root, no standardisation.... When choosing the best ashwagandha for you, choose products that are likely to work.

What makes the case for choosing KSM-66?

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Patented formula

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Having a patented formula can indicate that a product is innovative, differentiates it from others on the market and may provide additional benefits over other similar productsand.

The Ixoreal company - the creator of KSM-66 - is the only producer of ashwagandha in the world with its own farms, production facilities, testing laboratories, research centre and distribution, and it took 14 years to develop this formula .

Ashwagandha root extract is extracted using a unique proprietary process based on 'green chemistry' principles, making the formula pure and free of unnecessary additives. In short, you won't find another raw material like it.

High-quality extract

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KSM-66 is an ashwagandha root extract with a high concentration of 5% vitanolides and the most bioavailable, full spectrum on the market. By keeping all the natural constituents of this plant in 'original balance', you can realise 100% of the potential of vitanolides and feel its positive effects on your body.

The balance of compounds in ashwaganda refers to the proportions and ratios between the bioactive components that are present in it. The plant contains a variety of compounds, including alkaloids, vitanolides, sterols and lactonesand.

It is important to use appropriate methods of ashwagandha extraction and processing to maintain this balance and extract the full potential of the active substances - adds pharmacist.

Scientific research

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Ixoreal is an industry leader in clinical and basic research into the efficacy of ashwagandha. It collaborates with academic and research institutes. All clinical trials conducted by the company follow 'gold standards' - randomised, double-blinded and placebo-controlled.

The company boasts 24 scientific studies using KSM-66, the results of which suggest its comprehensive positive effects in study participants.

Vitanolides content

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Preparations with the KSM-66 formula contain a high percentage of vitanolides. They are responsible for most of the health and mental benefits. It contains 5% concentration of vitanolides measured by HPLC ( High-Performance Liquid Chromatography).

HPLC is an advanced chromatographic technique that is widely used in analytical, scientific and industrial research. It is a method that is used for the separation, identification and quantification of chemicals in samplesand.

Vitanolides found in plants are organic chemical compounds that have high biological activity. This means that they can have antimicrobial, antiviral, antioxidant and anti-inflammatoryand, among other effects.

Studies have shown that extracts of withania somnifera exhibit numerous therapeutic effects, including reduction of inflammation, oxidative stress, improvement of memory and cognitive function.

Certificates

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KSM-66 has an impressive number of certifications that prove that the raw material as well as its production process is of high quality. The formula and its production have passed the most extensive inspections and safety assessments in the industry.

Certifications that KSM-66 holds include:

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• GMP good manufacturing practices,
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• 100% USDA Organic,
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• Non-GMO,
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• Gluten Free,
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• BSCG-drug free,
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• Kosher, Halal,
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• HACCP,
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• GRAS,
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• Vegan,
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Results of scientific studies

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Research conducted by Ixoreal using KSM-66 tested how regular supplementation of various daily servings of this formula affects several areas of health.

Most important information about the study:

• The study lasted 8-10 weeks.
• The participants were given the following information.
• Participants were typically given 600 mg of the extract divided into 2 daily servings or a placebo.
• Participants were given the following.
• Participants from different age groups were included in the studies.
• Two studies were conducted.
• Two studies were conducted with animals, one using an in vitro method.
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Analysis of studies involving humans

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The results were within normal limits.

Studies involving animals

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Horses

The effects of ashwagandha on stress and overall health in horses were studied. Twenty-four Kathiawari animals were divided into 2 groups - one consuming normal feed and the other consuming feed with different amounts of ashwagandha root extractand.

It is worth adding that horses of this breed are used as pack animals (carrying goods) and in equestrianism. This exposes them to physical as well as psychological stress.

After 3 weeks, horses consuming feed with the extract showed a reduction in concentrations of  cortisol, triglycerides and epinephrine (adrenaline), among others.

Dogs

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In this 4-week study, 24 dogs experiencing stress and anxiety received either placebo or 15 mg/kg body weight of ashwagandha root extract daily. Outcome measures included urinary cortisol/creatine ratio, the Canine Behavioural Assessment and Research Questionnaire, the Canine Brief Pain Inventory (CBPI) pain scale and the Body Condition Score (BCS)and.

The results suggest that taking ashwagandha root extract reduced symptoms related to stress, anxiety and worry, and pain severity. It was also associated with a statistically significant reduction in the urinary cortisol/creatine ratio.

Take of Ashwagandha was well tolerated by all dogs and no adverse effects were reported.

In vitro study

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In an 'in glass' study, human HeLa cells were treated with different concentrations of ashwagandha root extract. The results showed an increase in telomerase (enzyme) activity, suggesting that KSM-66 has anti-ageing potentialand.

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Telomerase activity is important because this enzyme is responsible for 'rebuilding' telomeres, the ends of DNA that naturally shorten during cell replication. If telomeres shorten too much, cells stop dividing properly, which is one aspect of the ageing processand.

KSM-66 for... hair?

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A recent study from 2023 tested the effects of ashwagandha KSM-66 on hair loss. Study participants were to apply topically 1-2 drops per day of aqueous ashwagandha root extract to the scalpand.

After 75 days ashwagandha:

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• significantly reduced hair loss,
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• increased their density and thickness,
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• improved hair growth,
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Performed much better than the group of people in this study who applied a placebo to the scalp.

Findings from the study on the effects of KSM-66

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The researchers experienced beneficial effects from taking ashwagandha KSM-66 using 600 mg of the extract (divided into 2 daily servings) daily for 8 weeks. This is a valuable tip to stick to systematics and... be patient.

According to research, taking KSM-66 extract of ashwagandhaand:

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• reduces mental stress and tension,
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• positively affects mood,
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• improves memory and concentration,
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• increases performance and endurance,
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• enhances post-workout recovery,
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• increases testosterone and thyroid hormones,
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• relieves some symptoms of menopause,
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• promotes sexual health in men and women,
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• has antioxidant and tonic effects on the body,
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The consumption of ashwagandha KSM-66 is safe, well tolerated and free of adverse effects in healthy adults and animals.

See also compositional analyses:

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• Ashwagandha Naturell
• Ashwagandha Aliness
• Ashwagandha Swanson
• Ashwagandha Solgar
• Ashwagandha SFD
• Swanson Berberine

Who can benefit from the use of KSM-66?

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Ashwagandha may be helpful for you if: 

• you want to improve your memory and concentration,
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• you feel chronic fatigue,
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• you live with mental tension, 
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• you have problems falling asleep and relaxing,
• you have problems sleeping,
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• you suffer from moderate sleep problems,
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• you want to improve sports performance - strength as well as endurance, 
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• you want to improve your sexual health,
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• you are in the difficult period of menopause,
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Contraindications to use

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The use of ashwagandha extract preparations is not suitable forand:

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• pregnant and breastfeeding women,
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• persons under 18 years of age,
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• patients with autoimmune diseases (including thyroid disease, rheumatoid arthritis, diabetes, multiple sclerosis),
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• persons with bleeding disorders and gastric ulcers,
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• persons planning surgery,
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Also, ashwagandha should not be used with certain medications. Below is a list of medications and examples of popular preparations in Poland that belong to this group.

Ashwagandha should not be combined with medications:

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• blood-thinning drugs, e.g. Warfin, Pradaxa, Xarelto, Aspirin, Acard,
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• used in the treatment of disorders thyroid conditions, e.g. Letrox, Eurhyrox, Thyrozol,
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• inhibitors of the immune system, e.g. Metypred, Prograf, Equoral, Endoxan, Azathioprine, 
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• used for the treatment of depression or anxiety, e.g. Trittico, Dulsevia, Pramolan, Anafranil, Amitriptyline,
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• insomniacs, e.g. Zopiclone, Zolpidem, Trittico,
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• for high blood pressure, e.g. Torsemed, Captopril, Prestarium, Telmizek, Hydrochlorothiazide,
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• antidiabetics, e.g. Pioglitazone, Metformax, Amaryl, Forxiga, Jardiance.
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Ashwagandha KSM-66 - side effects

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A number of studies confirm that ashwagandha is considered a safe supplement for most people when taken in an optimal daily dose and for no more than 12 weeks.

However, Indian ginseng can cause various side effects in some people, and the most common areand:

• abdominal pain,
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• nausea,
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• vomiting,
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• headache,
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• insomnia, insomnia and nightmares,
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According to some scientific studies, the use of ashwagandha may adversely affect thyroid function and interfere with hormone production - particularly in the case of hypothyroidismand. Occasionally this plant may cause a skin rash and a doctor should be consulted.

See also:

• Cordyceps
• Soplum echinacea
• Lion's Mane
• Reishi
• Berberine
• Maca root
• Chaga mushroom
• Passionflower
• Curcuma
• Piperine
• Martyrium
• Caffeine
• Maccharine

Summary

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