Lysine benefits, side effects, and best supplements 2025

Lysine is a small amino acid that is important for your body. More so than you might think.

AuthorMateusz Podlecki

Author

Mateusz Podlecki

Writer

At Natu.Care, she educates about healthy lifestyles and debunks dangerous myths, contrasting them with the results of the latest scientific research. Additionally, she is interested in new technologies and their impact on health and everyday life.

Learn more about our editorial process

Reviewed byIlona Bush

Verified by an expert

Reviewed by

Ilona Bush

Master of Pharmacy

Ilona Krzak obtained her Master of Pharmacy degree from the Medical University of Wrocław. She did her internship in a hospital pharmacy and in the pharmaceutical industry. She is currently working in the profession and also runs an educational profile on Instagram: @pani_z_apteki

Learn more about our editorial process

Edited byBart Turczynski

Edited by

Bart Turczynski

Editor-in-Chief

Bart Turczynski is the editor-in-chief of Natu.Care. He is responsible for the quality of the content created on Natu.Care, among others, and ensures that all articles are based on sound scientific research and consulted with industry specialists.

Learn more about our editorial process

Fact-checkingLudwik Jelonek

Fact-checking

Ludwik Jelonek

Natu.Care Editor

Ludwik Jelonek is the author of more than 2,500 texts published on leading portals. His content has found its way into services such as Ostrovit and Kobieta Onet. At Natu.Care, Ludwik educates people in the most important area of life - health.

Learn more about our editorial process

Lysine benefits, side effects, and best supplements 2025

Updated:03 December, 2024

16 min

Why you can trust us

Articles on Natu.Care are written based on scientific research, data from government websites and other reliable sources. The texts are written in cooperation with doctors, nutritionists and other health and beauty experts. Articles are reviewed before publication and during significant updates.

Learn more about our editorial process

Information on advertisements

Information about advertisements

Content on Natu.Care may contain links to products from the sale of which we may receive a commission. When creating content, we adhere to high editorial standards and take care to be objective about the products discussed. The presence of affiliate links is not dictated by our partners, and we select the products we review ourselves completely independently.

Learn more about our terms and Conditions

Media about us:

Our body is a perfectly designed machine in which every element matters. Even the smallest ones. That's where lysine comes in - an amino acid without which a lot in your body starts to fail.

With educator and pharmacist, Ilona Krzak, we will take a closer look at what exactly lysine is and why it is so important for you.

From this article you will learn:

What lysine and collagen have in common.
What you need to know.
What are the symptoms and effects of lysine deficiency.
Which products contain the most lysine.
What is the most lysine?
Whether lysine is worth supplementing.
Why it is worth combining lysine with vitamin C.
Will lysine help with herpes.
Why is lysine worth supplementing?

Natu.Care Slim Protein, Bourbon Vanilla — Discover why Slim Protein Bourbon Vanilla is a protein you'll want to come back to every day.

Convenient dosing, easy to fit around your own schedule. High-quality supplement. Worth every penny, highly recommend.

Agata

Scopri di più

See also:

What is lysine?

Lysine (L-lysine, lysine, Lys, abbreviated K) is one of the essential essential amino acids. It means that your body is unable to produce it on its ownand and you must supply it along with your diet.

Essentially, because it has many key functions - from regenerating damaged tissues, producing proteins (including collagen) and supporting calcium metabolism, to protecting against atherosclerosis and strengthening the immune systemand.

What is the role of lysine in the body and what does it help with?

Amino acids are crucial to our lives. Ba, we are made up of amino acids. They are what tissues are made of; they are what participate in many processes and regulate the functions of individual cells.

And what exactly does a leaf do?

And what exactly does lysine do? Here are some of its extraordinary powers.

Aids in collagen synthesis

Lysine is a key amino acid in collagen synthesis. This is because it participates in the hydroxylation process, which increases the stability and strength of collagen fibresand. Adequate levels of lysine are necessary to maintain the health and elasticity of skin, tendons and all collagen-rich tissues.

See also:

Promotes wound healing

Lysine also improves the ability to heal woundsand. At the wound site, lysine acts as binding agents, stimulating cells to grow. They will appear faster, there will be more of them - so regeneration will happen faster and more effectivelyand.

Wound healing is a complex process involving many factors, vitamins and minerals - the role of lysine here is invaluableand.

Strengthens joints and bones

Lysine is also an important element in calcium metabolism - it increases calcium absorption in the gut and helps the kidneys retain it in the body.

A study of 30 women (including 15 with osteoporosis) showed that calcium supplementation (3 g) and lysine (400 mg) significantly reduced urinary calcium lossand.

Lysine also protects your bones and helps to control the transport of calcium in your body, preventing excessive accumulation in, among other things, blood vessels .

Alleviates herpes

herpes is an unpleasant infection that manifests as small, fluid-filled blisters at the corners of the mouth. They cause discomfort, tingling, pain and burning. Herpes is caused by the HSV-1 virus , but lysine supplementation inhibits the secretion of arginine, the amino acid responsible for the spread of the virus .

Supplementation of at least 3000 mg (3 g) per day is shown to be effective. Doses of less than 1000 mg (1 g) have no effect in either the treatment or prevention of herpes.

Ilona Krzak Master of Pharmacy

Inhibits stress and anxiety

Lysine may also play an important role in reducing anxiety, feelings of restlessness and lowering the stress hormone, cortisol and. This is because it blocks the action of receptors involved in the stress response.

Effects are dose-dependent - in one study, lysine and arginine supplementation produced effects after one week and in another after three months .

See also:

Other uses of lysine

Lysine - as a building block of proteins - is involved in the production of hormones, enzymes and antibodies. It also exhibits properties that may benefit in the following areas:

Hypertension: lysine supplements significantly lower blood pressureand;
Diabetes: preliminary studies suggest that lysine may help regulate blood glucose levels, but this has not been observed in older people ;
Immune system: increases immunity and relieves symptoms of infection;
Atherosclerosis: reduces its risk by strengthening the cardiovascular system;
Cancer: in combination with antioxidants, it can prevent the formation and spread of cancer cells;
Eyes: lysine for the eyes has a multifaceted effect - it helps fight 'dry eye syndrome' , and one study suggests that lysine supplementation may prevent the development of cataracts .

Lysine is also important for normal muscle growth and renewal and is involved in the formation of carnitine, which is found in most cells in your body. Lysine also helps cells transport fat to provide you with energyand.

Lysine deficiency - symptoms and effects

Although lysine deficiency is quite rare, it can occur with long-term restrictive or protein-poor diets. Vegans are particularly prone to deficiency.

The most common symptoms of lysine deficiency areand:

decreased immunity,
anemia,
feeling of fatigue,
dizziness,
problems with memory and concentration,
weakness and hair loss,
decrease in energy,
bloody eyes,
stunted growth,
irritability,
problems with fertility and the reproductive system,
disordered growth,
disability,
skin problems,

Lysine deficiencies - best food sources

Make up lysine deficiencies with your daily diet.

Best sources of lysine.

The best sources of lysine are primarily foods with high protein content:

meat - red and poultry,
yellow cheeses and cottage cheese,
fish - especially cod, sardines, halibut and tuna,
chocolate,
nuts - almonds,
soya and soya products - tofu,
spirulina,
eggs,
red beans,
whole grain products,
wheat groats,
quinoa,
amaranth,

(Yes, there is chocolate on the list, but don't ignore the other 12 products!)

Already this short list shows that you can compose a variety of tasty lysine-rich meals every day and more - and for breakfast, lunch and a light dinner.

Do not sip lysine supplements (or other proteins) with a strong infusion of tea - it contains tannins, which reduce the bioavailability of proteins.

Ilona Krzak Master of Pharmacy

Lysine supplements - recommended preparations

If you have a known deficiency (or are concerned that you may have one), you can start lysine supplementation after consulting your doctor. Here are some products you may benefit from:

Peptan® F

Natu.Care Premium Collagen 5000 mg, natural

5.0

Collagen content: 5000 mg of marine collagen hydrolysate Peptan® F
Form: sachets with powder for drinking
Serving: 1 sachet daily
Sufficient for: 30 days
Available in five flavours: natural, mango-passion fruit, blackberry, strawberry-rhubarb, cocoa or a mix of flavours

Check Price

Product Description

Premium Collagen 5000 mg by Natu.Care is pure hydrolysed fish collagen Peptan® F — a branded raw material of the highest quality, sourced from white fish, free from heavy metals and dioxins. This is type I collagen, identical to that which naturally occurs in the human body, responsible for the elasticity, firmness, and regeneration of the skin.

Regular supplementation supports a healthy appearance of skin, hair, and nails, and positively affects joints, bones, and overall body condition. Clinical studies confirm the effectiveness of Peptan® F — it improves skin elasticity by 19%, increases hydration by 12%, and reduces the number of micro-wrinkles by 26%.

The formula contains as many as 18 amino acids, including glycine, proline, and hydroxyproline — key for the structure of connective tissue. Collagen in this form features a low molecular weight (2000 Da), ensuring high bioavailability. The product is free from gluten, lactose, and GMOs, and its neutral taste makes it easy to add to coffee, tea, porridge, smoothies, or yogurt.

Each sachet contains 5000 mg of bioactive collagen, only 19 kcal, and no unnecessary additives. It is a convenient and effective way to care for beauty from the inside out.

Pros and Cons

Pros:

Contains branded raw material Peptan® F — one of the most clinically studied fish collagens in the world.
Clinically proven effectiveness: +19% skin elasticity, +12% hydration, -26% fewer micro-wrinkles, +9% skin density, -31% fewer collagen fibre damages.
Type I collagen — identical to that which naturally occurs in the human body.
Low molecular weight (2000 Da) → high bioavailability.
Contains as many as 18 amino acids, including glycine, proline, and hydroxyproline — key for the regeneration of connective tissue.
Neutral taste — easy to add to coffee, tea, smoothies, porridge, or soup.
Only 19 kcal in one sachet.
Gluten-free, lactose-free, and GMO-free. Excellent solubility, without a fishy aftertaste.
Composition tested by an independent laboratory J.S. Hamilton. Production process certified by GMP (food safety).

Cons:

None

Branded raw material Seagarden®, pure composition

Natu.Care Premium Collagen Shot 10000 mg

5.0

Collagen content: as much as 10,000 mg of hydrolysed branded marine collagen Seagarden®
Additional active ingredients: vitamin C 80mg, low molecular weight hyaluronic acid 60mg, vitamin E 12mg, biotin 2500 µg.
Form: bottles with liquid for drinking
Portion: 1 bottle
Sufficient for: 15 days
Taste: delicious, tart-sweet forest fruits, without a fishy aftertaste

Check Price

Product Description

Fish collagen from the brand Natu.Care Seagarden® in a dose of 10,000 mg, based on certified high-quality ingredients whose effects are clinically proven. Sourced from wild Atlantic cod, free from dioxins and heavy metals.

Regular supplementation will positively impact the appearance of skin, hair, and nails – they will be rebuilt and strengthened from within. In addition to valuable collagen for health and beauty, it also offers other active ingredients that help maintain a youthful appearance of the skin, shiny hair, and strong nails.

The preparation contains a sufficient portion of active substance to positively affect joints, the musculoskeletal system, and immunity.

Natu.Care Premium Collagen has a delicious forest fruit flavour and its formula is based on the following active ingredients: hydrolysed marine collagen Seagarden®, extract from wild rose buds, and hyaluronic acid. Additionally, the product contains vitamin C, vitamin E, hyaluronic acid, and biotin for even better effects.

Pros and Cons

Pros:

Contains branded raw material Seagarden® from wild deep-sea cod caught from the clean waters of the Barents Sea. The action of collagen Seagarden® is clinically proven. The raw material has FSSC 22000 certification, MSC quality certification (supports sustainable fishing), Responsible Sourcing Audit programme (ethical catches), as well as kosher and Halal certifications.
The product composition has been tested by an independent and accredited laboratory J.S. Hamilton.
Hydrolysed collagen type I with optimal molecular weight - 3 kDa ensuring absorbability
Additives: vitamin C aids in collagen synthesis, hyaluronic acid supports skin hydration and joint health, vitamin E additionally cares for skin health, and biotin improves elasticity, regeneration, and strengthens the structure of skin and hair.
Delicious forest fruit flavour (without a fishy aftertaste)
Production takes place in a GMP-certified facility (food production standard).

Cons:

None.

Best overall

Natu.Care Collagen Premium 5000 mg, mango-maracuja

5.0

Collagen content: 5000 mg marine collagen hydrolysate
.
Additional active ingredients: vitamin C, low molecular weight hyaluronic acid (and L-theanine and coenzyme Q10 in cocoa flavoured collagen or vitamin A and vitamin E in mango–passion fruit flavoured collagen)
.
Form: powder sachets
.
Dose: 1 sachet per day
.
Sufficient for: 30 days
.

See price

Product description

Fish collagen from the Natu.Care brand in a dose of 5000 mg. The formula contains a sufficient portion of the active substance to positively affect your joints, musculoskeletal system and immunity.

Take care of your tendons, joint cartilage, ligaments, muscles and even bones by supplying them with the building blocks to function properly. Move without bólu and provide the necessary support for any physical activity.

And as a „gratis” to regular supplementation, you will also receive firm skinóhand, healthy and shiny hair and strong nails.

Natu.Care Premium Collagen is available in two flavours – Cacao Bloom and Rise&Shine. Both formulas are based on the following active ingredients: marine collagen hydrolysate, wild roseóbud extract and hyaluronic acid.

Additionally, Cacao Bloom contains natural L-theanine, coenzyme Q10 and defatted Dutch cacao. Rise&Shine instead contains vitamin E and vitamin A.

These are the best collagens in the world.

These best fish collagens on the market also rós taste – Cacao Bloom is a treat for chocolate lovers. Rise&Shine will appeal to those whoóenjoy the refreshing taste of mangoófruit and passion fruit.

Pros and cons

Fish collagen from the Natu.Care brand in a dose of 5000 mg. The formula contains a sufficient portion of the active substance to positively affect your joints, musculoskeletal system and immunity.

And as a „gratis” to regular supplementation, you will also receive firm skinóhand, healthy and shiny hair and strong nails.

Additionally, Cacao Bloom contains natural L-theanine, coenzyme Q10 and defatted Dutch cacao. Rise&Shine instead contains vitamin E and vitamin A.

These are the best collagens in the world.

Additional information

Fish collagen from the Natu.Care brand in a dose of 5000 mg. The formula contains a sufficient portion of the active substance to positively affect your joints, musculoskeletal system and immunity.

And as a „gratis” to regular supplementation, you will also receive firm skinóhand, healthy and shiny hair and strong nails.

Additionally, Cacao Bloom contains natural L-theanine, coenzyme Q10 and defatted Dutch cacao. Rise&Shine instead contains vitamin E and vitamin A.

These are the best collagens in the world.

User review

Fish collagen from the Natu.Care brand in a dose of 5000 mg. The formula contains a sufficient portion of the active substance to positively affect your joints, musculoskeletal system and immunity.

And as a „gratis” to regular supplementation, you will also receive firm skinóhand, healthy and shiny hair and strong nails.

Additionally, Cacao Bloom contains natural L-theanine, coenzyme Q10 and defatted Dutch cacao. Rise&Shine instead contains vitamin E and vitamin A.

These are the best collagens in the world.

Natu.Care Collagen Glow Bar, toffee-flavoured bar

5.0

Collagen content: 2.4 g of branded, hydrolysed fish collagen Seagarden®

Additional active ingredients:

18.8 g of protein (WPC80 concentrate + calcium caseinate + soy crisps)
2.84 g of fibre (polydextrose)
Sweetened with xylitol and maltitol – 0 g added sugar
Natural additives: sugar-free milk chocolate, peanuts, natural flavours

Form: Functional protein-collagen bar with toffee flavour; serving: 1 piece / 40 g (also available in a box of 12 pieces)

Check Price

Product Description

Functional protein-collagen bar with a creamy toffee flavour, created as a quick snack that both satisfies and supports the skin thanks to bioactive collagen Seagarden®.

Pros and Cons

Pros:

High portion of protein and collagen in one bar
Zero added sugar, low glycemic index
Convenient format – fits in a bag, backpack, or on a desk

Cons:

None

Delicious fruity flavour

Natu.Care Premium Collagen 5000 mg, strawberry-rhubarb

5.0

Collagen content: 5000 mg marine collagen hydrolysate
Additional active ingredients: vitamin C, low molecular weight hyaluronic acid (as well as L-theanine and coenzyme Q10 in cocoa-flavoured collagen or vitamin A and vitamin E in mango-passion fruit, blackberry, strawberry-rhubarb flavoured collagen)
Form: sachets with powder for drinking
Portion: 1 sachet daily
Sufficient for: 30 days
Available in four flavours: mango, blackberry, strawberry-rhubarb, cocoa or a mix of flavours

Check Price

Product Description

Fish collagen from Natu.Care Seagarden in doses of 5000 mg or 10,000 mg, based on certified ingredients of the highest quality. Regular supplementation will positively impact the appearance of skin, hair, and nails – they will be rebuilt and strengthened from within.

In addition to the valuable collagen for health and beauty, it also offers other active ingredients that help maintain a youthful appearance of the skin, shiny hair, and strong nails.

The preparation contains a sufficient amount of active substance to positively affect joints, the musculoskeletal system, and immunity.

Natu.Care Premium collagen is available in four flavours: mango-passion fruit, blackberry, strawberry-rhubarb, and cocoa. All formulas are based on the following active ingredients: hydrolysed marine collagen, extract from wild rose buds, and hyaluronic acid.

Additionally, the cocoa collagen contains natural L-theanine, coenzyme Q10, and Dutch cocoa powder. The fruity flavours contain vitamin E and vitamin A.

These top fish collagens on the market also differ in taste – cocoa is a treat for chocolate lovers. Others will appeal to those who enjoy the refreshing taste of fruits.

Pros and Cons

Pros:

Contains branded raw material Seagarden® from wild deep-sea cod caught from the clean waters of the Barents Sea. The action of collagen Seagarden® is clinically proven. The raw material has FSSC 22000 Certification, MSC quality certification (supports sustainable fishing), Responsible Sourcing Audit (ethical catches), and kosher and Halal certifications.
The product's composition has been tested by an independent and accredited laboratory J.S. Hamilton.
Hydrolysed collagen type I with optimal molecular weight - 3 kDa ensuring absorption
Additives: vitamin C aids in collagen synthesis, hyaluronic acid supports skin hydration and joint health, vitamins A and E additionally care for skin health, coenzyme Q10 (cocoa flavour) has antioxidant properties.
Choice of four delicious flavours (no fish aftertaste): mango-passion fruit, blackberry, strawberry-rhubarb, and cocoa or mix of flavours.
Production takes place in a GMP-certified facility (food production standard).

Cons:

None.

Additional Information

Fish collagen from Natu.Care is praised for being delicious. You won't find the fishy aftertaste that often comes through in other collagens. And you have two delicious flavours to choose from: mango–passion fruit, blackberry, strawberry-rhubarb, and cocoa.

Active ingredients such as coenzyme Q10, hyaluronic acid, and natural L-theanine have anti-inflammatory, antioxidant effects and delay the aging process.

User Review

I have been using collagen for 3 months and I am delighted with the results, my skin is radiant and hydrated, my nails and hair are growing faster, and on top of that, it tastes great!

Aleksandra K. customer of Natu.Care

The best I have ever had. I have found the one. I have been using it for 8 months. Visible improvement in the condition of my hair and skin, and I won't switch to another. This is my favourite.

Monika M. customer of Natu.Care

Refreshing taste

Natu.Care Premium Collagen 5000 mg, blackberry

5.0

Collagen content: 5000 mg of hydrolysed marine collagen
Additional active ingredients: vitamin C, low molecular weight hyaluronic acid (as well as L-theanine and coenzyme Q10 in collagen with cocoa flavour or vitamin A and vitamin E in collagen with mango-passionfruit, blackberry, strawberry-rhubarb)
Form: sachets with powder for drinking
Portion: 1 sachet daily
Sufficient for: 30 days
Available in four flavours: mango, blackberry, strawberry-rhubarb, cocoa or mix of flavours

Check Price

Product Description

Fish collagen from the brand Natu.Care Seagarden in doses of 5000 mg or 10,000 mg, based on certified high-quality ingredients. Regular supplementation will positively impact the appearance of skin, hair, and nails – they will be rebuilt and strengthened from within.

In addition to valuable collagen for health and beauty, it also offers other active ingredients that help maintain a youthful appearance of the skin, shiny hair, and strong nails.

The preparation contains a sufficient portion of active substance to positively affect joints, the musculoskeletal system, and immunity.

Natu.Care Premium Collagen is available in four flavours: mango-passion fruit, blackberry, strawberry-rhubarb, and cocoa. All formulas are based on the following active ingredients: hydrolysed marine collagen, extract from wild rose buds, and hyaluronic acid.

Additionally, the cocoa collagen contains natural L-theanine, coenzyme Q10, and Dutch-processed cocoa. The fruit flavours contain vitamin E and vitamin A.

These top fish collagens on the market also differ in taste – cocoa is a treat for chocolate lovers. Others will appeal to those who enjoy the refreshing taste of fruits.

Pros and Cons

Pros:

Contains branded raw material Seagarden® from wild deep-sea cod caught from the clean waters of the Barents Sea. The action of collagen Seagarden® is clinically proven. The raw material has FSSC 22000 certification, MSC quality certification (supports sustainable fishing), Responsible Sourcing Audit programme (ethical catches), as well as kosher and Halal certifications.
The product composition has been tested by an independent and accredited laboratory J.S. Hamilton.
Hydrolysed collagen type I with optimal molecular weight - 3 kDa ensuring absorbability
Additives: vitamin C helps in collagen synthesis, hyaluronic acid supports skin hydration and joint health, vitamins A and E additionally care for skin health, coenzyme Q10 (cocoa flavour) has antioxidant properties.
Choice of four delicious flavours (without a fishy aftertaste): mango-passion fruit, blackberry, strawberry-rhubarb, and cocoa or flavour mix.
Production takes place in a GMP-certified facility (food production standard).

Cons:

None.

Additional Information

Fish collagen from Natu.Care is praised for being delicious. You won't find a fishy taste here, which often comes through in other collagens. And you have two delicious flavours to choose from: mango–passion fruit, blackberry, strawberry-rhubarb, and cocoa.

Active ingredients such as coenzyme Q10, hyaluronic acid, or natural L-theanine have anti-inflammatory, antioxidant effects and delay the aging process.

User Review

It reminds me of childhood with its scent, I feel nostalgic :) After 2 packs of collagen from Natu, my facial inflammations have calmed down, and the "rash" has completely disappeared. I recommend!

Kuba K. customer of Natu.Care

Super flavour surprise, no artificial sweetness that I detected in the mango-passion fruit collagen. I have already recommended collagen to 4 other people, all of whom decided to subscribe :) I see a smoothing of wrinkles, especially on my forehead, and better-hydrated skin.

Kinga D. customer of Natu.Care

Best for joints

Natu.Care Collagen Premium 10000 mg, cherry

5.0

Collagen content: 10,000 mg of hydrolyzed bovine collagen
Additional active ingredients: vitamin C, low molecular weight hyaluronic acid, glucosamine, chondroitin, extract of Indian frankincense resin (boswellia serrata)
Form: powder sachets for drinking
Serving: 1 sachet per day
Lasts for: 30 days

See price

Product description

One of the strongest collagens on the market, providing as much as 10,000 mg per daily serving. This product can effectively support the condition of joints, skin, hair, and nails.

With this supplement, you will support your skeletal and joint system as well as your beauty, helping you visually halt the aging process and feel rejuvenated!

Pros and cons

Pros:

The daily portion of collagen is very large – as much as 10,000 mg.
Proven collagen formula – COLLinstant, whose effectiveness has been confirmed in clinical studies.
Effective dose of hyaluronic acid, which additionally moisturizes the skin and positively affects joint health.
Vitamin C supports the body's natural collagen production.
Glucosamine is a fundamental building block of compounds found in joint cartilage and a component of collagen that gives elasticity to connective tissue in tendons.
Chondroitin is a natural component found in the human body, mainly in cartilage. This large molecule (mucopolysaccharide) has the ability to absorb water, which helps maintain the elasticity and resilience of cartilage.
Frankincense resin extract supports blood circulation and joint mobility and reduces their stiffness. It may help alleviate inflammatory conditions.
The composition has been tested by the independent and accredited J.S. Hamilton laboratory.

Cons:

None.

Additional information

Users praise Natu.Care Collagen Premium for the easy dissolving of the powder.

ALLDEYNN Collarose Fish

4.7

Collagen content: 5000 mg hydrolysate fish collagen VERISOL F®
Additional active ingredients: vitamin C, hyaluronic acid, biotin
Form: powder to dissolve in water
Dose: one scoop (6 g) of powder daily
Sufficient for: 50 days

See price

Product description

Atlantic cod collagen VERISOL F® contained in the formula are easily absorbed collagen peptides of fish origin. Regular supplementation can firm your skinóhand and slow down the ageing process. Your nails will become stronger and stop breaking. The addition of biotin will improve the condition of your hairów. The collagen portion is high enough to also have a good effect on your joints, muscles and bones.

Pros and cons

Additional information

Expert and user opinion

DuoLife Collagen fish collagen 2500 mg

4.0

Collagen content: 2500 mg collagen
Additional active ingredients: vitamin C, silicon, glucosamine, hyaluronic acid, nettle and bamboo extracts
Form: liquid to drink
Dose:25 ml

.
Sufficient for: 30 days
.

See price

Product description

100% natural collagen liquid without unnecessary ingredientsós. The composition of ingredientsós improves the appearance and condition of skinóry, hairów, nails. DuoLife is a good choiceór if you notice the first signs of skinóry ageing or want to stop this process. A tasty liquid, convenient to use.

Pros and cons

Additional information

User review

Convenient form

Pharmovit liquid collagen 10000 mg

4.6

Collagen content: 10000 mg hydrolysed bovine collagen types I and III
Additional active ingredients: hyaluronic acid, natural plant extracts, vitamin C, B vitamins, zinc, vitamin D
Form: vials
Dose: 25 ml
Sufficient for: 20 days

See price

Product description

A solid daily dose of collagen for jointómuscle and bone health and beauty. The duo of collagen and vitamin C has a positive effect on each other, so that „the protein of youth” is better absorbed and more efficiently produced in the body.

Pros and cons

Additional information

High dose

KFD Premium Collagen+

4.9

Collagen content: 12,440 mg of gelatin collagen hydrolysate
Additional active ingredients: vitamin C, vitamin D, MSM, hyaluronic acid, calcium, frankincense resin extract
Form: powder to be dissolved in water
Dose: 4 scoops (20 g) of powder daily
Sufficient for: 20 days

See price

Product description

High dose of collagen and a real bomb of vitamins C and D and organic sulphur. With this preparation the effects will come immediately. You will improve the firmness of your skin and reduce wrinkles. Your hair and nails will be strong and shiny.

A generous dose of collagen will improve the mobility of your jointsós, benefit your bone system and muscles. Do you do sports and need a product thatós able to keep up with your needs? This product will do the trick.

Pros and cons

Additional information

Expert opinion

Pork collagen

SFD Collagen Premium

4.2

Collagen content: 12,440 mg of hydrolysed pork collagen
Additional active ingredients: vitamin C, hyaluronic acid glucosamine sulfate, extract from frankincense resin, calcium, organic sulfur MSM, manganese, vitamin D
Form: strawberry-raspberry flavoured powder
Serving: 20 g (2 scoops) daily
Lasts for: 20 days

Check Price

Product Description

SFD Collagen Premium is hydrolysed pork collagen with added ingredients that support joint health.

Pros and Cons

Pros:

Vitamin C supports the production of collagen by the body, enhancing its effectiveness.
High dose of collagen.
Tested composition.

Cons:

The manufacturer does not specify the source of the raw material.
Pork collagen does not guarantee the same bioavailability as fish collagen.

Collagen Reme

4.0

Collagen content: 2500 mg pork collagen
Additional active ingredients: vitamin C, niacin (vitamin B3), riboflavin (vitamin B2), vitamin A, biotin, vitamin D, zinc, manganese, copper, iodine, selenium
Form: powder
Dose: one scoop per day
Sufficient for: 30 days

See price

Product description

The dietary supplement from Remé contains beef collagen in a patented formula and vitamin C, whichóra aids its absorption. The formula comes in three flavours: neutral, orange-maracuja and strawberry-pomegranate. The formula can effectively support and improve the condition of the skinóry, hairóry and nails.

Pros and cons

Additional information

Check out other Solgar brand supplements.

Lysine supplementation - what do you need to know?

Lysine supplementation is safe, however, there are some important things to know.

Lysine or L-lysine?

The right lysine supplement is a product that will contain free lysine (i.e. preceded by the letter L), or L-lysine. Choose this for its better bioavailability and absorption. L-lysine is easily digestible and goes directly into the bloodstream without loss - you don't need to digest it.

Dosage

The safe adult dose of lysine for daily intake is approximately 12 mg for every kilogram of body. In practice, this means that an adult weighing 65 kg should consume approximately 780 mg of lysine per day.

Research suggests that...

For therapeutic purposes, one should take between 100 and 4,000 mg of lysine per dayand.

Dosage depends on age, health or nutritional needs, so always stick to the manufacturer's directions and consult your doctor before starting supplementation.

L-lysine supplementation at a dose of 3 g per day increases the activity of lysozyme, which is a bactericidal enzyme and protects against the spread of infection.

Ilona Krzak Master of Pharmacy

Natu.Care Slim Protein, Pistachio — Discover why Slim Protein Pistachio is the protein chosen when flavour and consistency matter.

A very tasty and light shake, great in the evening or between meals. It's not overly sweet. If the pistachio version is too sweet for someone, the vanilla one is a good alternative.

Katarzyna

Scopri di più

Can you overdose on lysine?

Although lysine is considered safe, non-toxic, and there is no indication of a maximum dose, consuming it in large amounts can lead to undesirable side effects.

Some researchers suggest that you should not take more than 6000 mg (6 g) of lysine per dayand

Side effects

The most common side effects caused by lysine supplementation , are:

abdominal pain,
diarrhoea,
nausea,

Gastrointestinal complaints usually last a short time and do not require a medical consultation. If symptoms persist, see a doctor.

Rarely.

Very rarely, serious symptoms such as kidney failure or gallstones may occurand.

Contraindications and possible interactions

The main contraindications to taking lysine supplements are mainlyand:

pregnancy and breastfeeding;
calcium supplementation - lysine increases the amount of calcium absorbed, which can lead to so-called hypercalcaemia;
lysine protein intolerance - a rare condition in which the body poorly digests lysine and other amino acids;
planned surgery in the near future;

Do not use lysine supplements on your own without consulting your doctor if you are taking:

arginine - high levels of arginine can reduce lysine levels;
aminoglycoside antibiotics (e.g. gentamicin, streptomycin or neomycin) - use with lysine may increase the risk of nephrotoxicity, i.e. negative effects on kidney function;

People with pyridoxine-dependent epilepsy should also be wary of lysine supplementation. Studies have shown that it can generate seizuresand.

Ilona Krzak Master of Pharmacy

Natu.Care Premium Collagen 5000 mg, cocoa — See what Natu.Care Premium Collagen 5000 mg can do for your health and beauty -15% with code BLOG15

I started noticing results after about 5 weeks. My hair is hydrated and has stopped falling out. My sensitive skin has stopped drying out too. Extra points for the delicious taste!

@Milena Dlugosz

Scopri di più

See also:

Summary

In summary

Lysine is an important amino acid that is involved in the construction of proteins, enzymes and hormones.
Lysine is an important amino acid that is involved in the construction of proteins, enzymes and hormones.
It aids wound healing, collagen production and the fight against herpes.
It is an important amino acid.
Must supply it with food.
The best sources of lysine are high-protein foods, including red and white meat, eggs, tofu or legumes.
Lysine deficiency is rare, although it can cause symptoms such as weakened immunity, decreased energy, growth problems, dizziness or hair loss.
People on restrictive diets, including vegans, are mainly at risk of lysine deficiency.
For supplementation, choose preparations with free lysine (L-lysine) - it is better absorbed.

FAQ

What vitamin is missing when herpes occurs?

Perpes is a viral disease and one of the causes of herpes can be insufficient vitamins and minerals, including antioxidants, which are closely linked to your immunity. These may include:

In addition to these, lysine is also important, a reduced amount of which increases susceptibility to herpes.

Why combine lysine with vitamin C?

Vitamin C and lysine play a huge role in our body. They interact with many processes and can enhance each other's effects, including:

promoting collagen production,
supporting the immune system,
improving the absorption of minerals, e.g. iron.

Can I take lysine every day?

Lysine supplementation is safe and there is no set maximum dose. Some studies suggest not to exceed 6 g (6000 mg) of lysine per day. Lysine overdose can cause gastrointestinal unpleasantness, including nausea and diarrhoea.

See: When to drink collagen?

What is the most lysine in?

The best sources of lysine are foods that are high in protein, including white and red meat, beans, tofu, dark chocolate, almonds, spirulina, halibut, salmon, tuna, quinoa or amaranth.

See: What collagen is - the best sources

What is limited by lysine?

Research shows that lysine inhibits the production of arginine, an amino acid that is responsible for, among other things, the spread of the herpes virus in your body.

Is my body producing lysine?

No. Lysine is an amino acid exogenous, which means your body does not produce it. It is necessary to supply lysine along with food. If you have a known deficiency, you can start lysine supplementation. Before doing so, consult your doctor to determine the dosage.

Which lysine is best?

The best lysine is a high-quality supplement that comes from a reputable manufacturer. When choosing a particular product, pay attention to the form (reach only for free lysine - L-lysine), the purity of the composition (check for unnecessary additives and allergens), the dosage (you will encounter mainly 500 and 1000 mg on the market). It is also worth reading reviews on both the product and the manufacturer.

Resources

See all

Apparent Protein and Energy Digestibility and Amino Acid Availability of Corn and Co-products in Extruded Diets for Nile Tilapia, Oreochromis niloticus. (n.d.). https://doi.org/10.1111/jwas.12184

Chen, C., Sander, J. E., & Dale, N. M. (2003). The Effect of Dietary Lysine Deficiency on the Immune Response to Newcastle Disease Vaccination in Chickens. Avian Diseases, 47(4), 1346-1351. https://doi.org/10.1637/7008

Civitelli, R., Villareal, D. T., Agnusdei, D., Nardi, P., Avioli, L. V., & Gennari, C. (1992). Dietary L-lysine and calcium metabolism in humans. Nutrition (Burbank, Los Angeles County, Calif.), 8(6), 400-405.

Cold sores: Overview. (2018). In InformedHealth.org [Internet]. Institute for Quality and Efficiency in Health Care (IQWiG). https://www.ncbi.nlm.nih.gov/books/NBK525782/

Congestive Heart Failure Treated with a Multiple Micronutrient Supplement Program: A Case Report. (n.d.). Journal of Clinical & Medical Case Reports. Retrieved April 27, 2023, from https://www.avensonline.org/fulltextarticles/JCMCR-2332-4120-02-0015.html

Coughlin, C. R., Tseng, L. A., Bok, L. A., Hartmann, H., Footitt, E., Striano, P., Tabarki, B. M., Lunsing, R. J., Stockler-Ipsiroglu, S., Gordon, S., Van Hove, J. L. K., Abdenur, J. E., Boyer, M., Longo, N., Andrews, A., Janssen, M. C., van Wegberg, A., Prasad, C., Prasad, A. N., ... International PDE Consortium. (2022). Association Between Lysine Reduction Therapies and Cognitive Outcomes in Patients With Pyridoxine-Dependent Epilepsy. Neurology, 99(23), e2627-2636. https://doi.org/10.1212/WNL.0000000000201222

Crowther, L. M., Mathis, D., Poms, M., & Plecko, B. (2019). New insights into human lysine degradation pathways with relevance to pyridoxine-dependent epilepsy due to antiquitin deficiency. Journal of Inherited Metabolic Disease, 42(4), 620-628. https://doi.org/10.1002/jimd.12076

Deng, J., Zhang, X., Tao, L., Bi, B., Kong, L., & Lei, X. (2011). D-lysine can be effectively utilized for growth by common carp (Cyprinus carpio). Aquaculture Nutrition, 17(2), e467-e475. https://doi.org/10.1111/j.1365-2095.2010.00783.x

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). (2013). Scientific opinion on the safety and efficacy of concentrated liquid L-lysine (base), concentrated liquid L-lysine monohydrochloride and L-lysine monohydrochloride produced by Escherichia coli (FERM BP-10941) for all animal species, based on three dossiers submitted by Ajinomoto Eurolysine SAS. EFSA Journal, 11(10), 3365. https://doi.org/10.2903/j.efsa.2013.3365

FoodData Central. (n.d.). Retrieved April 26, 2023, from https://fdc.nal.usda.gov/fdc-app.html#/?component=1214

Hall, S. L., & Greendale, G. A. (1998). The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study. Calcified Tissue International, 63(3), 183-189. https://doi.org/10.1007/s002239900512

Hayamizu, K., Oshima, I., & Nakano, M. (2020). Comprehensive Safety Assessment of l-Lysine Supplementation from Clinical Studies: A Systematic Review. The Journal of Nutrition, 150(Supplement_1), 2561S-2569S. https://doi.org/10.1093/jn/nxaa218

Kalogeropoulou, D., LaFave, L., Schweim, K., Gannon, M. C., & Nuttall, F. Q. (2009). Lysine ingestion markedly attenuates the glucose response to ingested glucose without a change in insulin response. The American Journal of Clinical Nutrition, 90(2), 314-320. https://doi.org/10.3945/ajcn.2008.27381

Liao, S. F., Wang, T., & Regmi, N. (2015). Lysine nutrition in swine and the related monogastric animals: Muscle protein biosynthesis and beyond. SpringerPlus, 4(1), 147. https://doi.org/10.1186/s40064-015-0927-5

Lin, L.-Y., Bhate, K., Forbes, H., Smeeth, L., Warren-Gash, C., & Langan, S. M. (2021). Vitamin D Deficiency or Supplementation and the Risk of Human Herpesvirus Infections or Reactivation: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, 8(1), ofaa570. https://doi.org/10.1093/ofid/ofaa570

Lin, P.-H., Jian, H.-J., Li, Y.-J., Huang, Y.-F., Anand, A., Huang, C.-C., Lin, H.-J., & Lai, J.-Y. (2022). Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels. Acta Biomaterialia, 141, 140-150. https://doi.org/10.1016/j.actbio.2022.01.044

Lo, J. C., Chertow, G. M., Rennke, H., & Seifter, J. L. (1996). Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. American Journal of Kidney Diseases, 28(4), 614-617. https://doi.org/10.1016/S0272-6386(96)90476-X

Lopez, M. J., & Mohiuddin, S. S. (2023). Biochemistry, Essential Amino Acids. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK557845/

Mailoo, V. J., & Rampes, S. (2017). Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence. Integrative Medicine: A Clinician's Journal, 16(3), 42-46.

Matthews, D. E. (2020). Review of Lysine Metabolism with a Focus on Humans. The Journal of Nutrition, 150, 2548S-2555S. https://doi.org/10.1093/jn/nxaa224

P, S., & G, C. (2017). A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS. Asian Journal of Pharmaceutical and Clinical Research, 219-221. https://doi.org/10.22159/ajpcr.2017.v10i5.16431

Pedrazini, M. C., da Silva, M. H., & Groppo, F. C.. (2022). L-lysine: Its antagonism with L-arginine in controlling viral infection. Narrative literature review. British Journal of Clinical Pharmacology, 88(11), 4708-4723. https://doi.org/10.1111/bcp.15444

Pougovkina, O., te Brinke, H., Wanders, R. J. A., Houten, S. M., & de Boer, V. C. J. (2014). Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism. Journal of Inherited Metabolic Disease, 37(5), 709-714. https://doi.org/10.1007/s10545-014-9684-9

PubChem. (n.d.). Lysine. Retrieved April 25, 2023, from https://pubchem.ncbi.nlm.nih.gov/compound/5962

Rutherfurd, S. M., Bains, K., & Moughan, P. J. (2012). Available lysine and digestible amino acid contents of proteinaceous foods of India. British Journal of Nutrition, 108(S2), S59-S68. https://doi.org/10.1017/S0007114512002280

Rutherfurd, S. M., & Moughan, P. J. (2005). Digestible Reactive Lysine in Selected Milk-Based Products. Journal of Dairy Science, 88(1), 40-48. https://doi.org/10.3168/jds.S0022-0302(05)72660-6

Schencking, M., Vollbracht, C., Weiss, G., Lebert, J., Biller, A., Goyvaerts, B., & Kraft, K. (2012). Intravenous Vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study. Medical Science Monitor, 18(4), CR215-CR224. https://doi.org/10.12659/MSM.882621

Singh, M., Rao, D., Pande, S., Battu, S., Rajeswar Dutt, K., & Ramesh, M. (2011). Medicinal Uses of L-Lysine: Past and Future. International Journal of Research in Pharmaceutical Sciences, 2.

Smriga, M., Ando, T., Akutsu, M., Furukawa, Y., Miwa, K., & Morinaga, Y. (2007). Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Biomedical Research (Tokyo, Japan), 28(2), 85-90. https://doi.org/10.2220/biomedres.28.85

Smriga, M., Ghosh, S., Mouneimne, Y., Pellett, P. L., & Scrimshaw, N. S. (2004). Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proceedings of the National Academy of Sciences of the United States of America, 101(22), 8285-8288. https://doi.org/10.1073/pnas.0402550101

Smriga, M., Kameishi, M., Uneyama, H., & Torii, K. (2002). Dietary L-Lysine Deficiency Increases Stress-Induced Anxiety and Fecal Excretion in Rats. The Journal of Nutrition, 132(12), 3744-3746. https://doi.org/10.1093/jn/132.12.3744

Spallotta, F., Cencioni, C., Straino, S., Sbardella, G., Castellano, S., Capogrossi, M. C., Martelli, F., & Gaetano, C. (2013). Enhancement of lysine acetylation accelerates wound repair. Communicative & Integrative Biology, 6(5), e25466. https://doi.org/10.4161/cib.25466

Sulochana, K. N., Punitham, R., & Ramakrishnan, S. (1998). Beneficial Effect of Lysine and Amino Acids on Cataractogenesis in Experimental Diabetes through Possible Antiglycation of Lens Proteins. Experimental Eye Research, 67(5), 597-601. https://doi.org/10.1006/exer.1998.0547

Terajima, M., Taga, Y., Chen, Y., Cabral, W. A., Hou-Fu, G., Srisawasdi, S., Nagasawa, M., Sumida, N., Hattori, S., Kurie, J. M., Marini, J. C., & Yamauchi, M. (2016). Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen *. Journal of Biological Chemistry, 291(18), 9501-9512. https://doi.org/10.1074/jbc.M115.699470

Tipton, K. D. (2015). Nutritional Support for Exercise-Induced Injuries. Sports Medicine (Auckland, N.z.), 45, 93-104. https://doi.org/10.1007/s40279-015-0398-4

Tomé, D., & Bos, C. (2007). Lysine Requirement through the Human Life Cycle. The Journal of Nutrition, 137(6), 1642S-1645S. https://doi.org/10.1093/jn/137.6.1642S

Ukmar-Godec, T., Hutten, S., Grieshop, M. P., Rezaei-Ghaleh, N., Cima-Omori, M.-S., Biernat, J., Mandelkow, E., Söding, J., Dormann, D., & Zweckstetter, M. (2019). Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications, 10(1), Article 1. https://doi.org/10.1038/s41467-019-10792-y

Vuvor, F., Mohammed, H., Ndanu, T., & Harrison, O. (2017). Effect of lysine supplementation on hypertensive men and women in selected peri-urban community in Ghana. BMC Nutrition, 3(1), 67. https://doi.org/10.1186/s40795-017-0187-6

Wang, W., Xu, Y., Chi, S., Yang, P., Mai, K., & Song, F. (2020). Dietary Lysine Regulates Body Growth Performance via the Nutrient-Sensing Signaling Pathways in Largemouth Bass (Micropterus salmoides). Frontiers in Marine Science, 7. https://www.frontiersin.org/articles/10.3389/fmars.2020.595682

Wu, M., Cronin, K., & Crane, J. S. (2023). Biochemistry, Collagen Synthesis. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK507709/

Yamauchi, M., & Sricholpech, M. (2012). Lysine post-translational modifications of collagen. Essays in Biochemistry, 52, 113-133. https://doi.org/10.1042/bse0520113

Yamauchi, M., Terajima, M., & Shiiba, M. (2019). Lysine Hydroxylation and Cross-Linking of Collagen. Methods in Molecular Biology (Clifton, N.J.), 1934, 309-324. https://doi.org/10.1007/978-1-4939-9055-9_19

Jelonek, L. (2023). Collagen. Everything you need to know (B. Turczynski, ed.; 1st ed.). Natu.Care. https://books.google.com/books?vid=9788396887801

Rate the article

4.5

Vote cast

463 opinions, rating: 4.5