Type 3 collagen (Supplements, benefits, and use)

Type 3 collagen is responsible for healing and regeneration. See what else you need to know about it.

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Mateusz Podlecki

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At Natu.Care, she educates about healthy lifestyles and debunks dangerous myths, contrasting them with the results of the latest scientific research. Additionally, she is interested in new technologies and their impact on health and everyday life.

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Ilona Bush

Master of Pharmacy

Ilona Krzak obtained her Master of Pharmacy degree from the Medical University of Wrocław. She did her internship in a hospital pharmacy and in the pharmaceutical industry. She is currently working in the profession and also runs an educational profile on Instagram: @pani_z_apteki

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Type 3 collagen (Supplements, benefits, and use)

21 August, 2024

Recenzja24 May, 2023

Redakcja30 May, 2023

Fact-checking26 June, 2023

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12 min

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Third on the list, and second in your body - is type III collagen. Type 3 collagen builds blood vessels, ensures better wound healing, regeneration and elasticity of your tissues, and on top of that it 'works' with type 1 collagen.

Together with pharmacist and educator Ilona Krzak, M.D., we will tell you everything you need to know about it in order to lead a healthier and better life.

From this article you will learn:

What type 3 collagen is.
What it is.
What type III collagen is responsible for in your body.
What is the difference between type 1, type 2 and type 3 collagen.
What is type 3 collagen?
What collagen supplements experts recommend.

See also:

What is type 3 collagen?

Collagen type III is a protein found in many tissues of the body, including the skin, lungs, liver, muscles or blood vesselsand. It provides structural support and helps maintain their integrity and elasticity. Type 3 collagen is important for wound healing, tissue regeneration and in blood clotting.

Collagen type III is the second most common type of collagen in the body and is often found with collagen type I, although it has less tensile strength. Over the years, type III collagen is replaced by type I collagen.

Best collagen - ranking of recommended products

Check out the expert-selected collagen supplements that also include type III collagen.

How do I choose the best collagen supplement?

If you are going to choose a collagen supplement, it is essential to pay attention to a few important aspects:

Collagen content: good supplements with collagen have a dose in the range of 2,500-15,000 mg (2.5-15 g). The optimal daily requirement is around 4,000-5,000 mg (4-5 g). Collagen is very difficult to overdose on, so it is better to take 10 000 mg than just 200 or 400 mg. The largest portions of collagen are collagen powder (in sachets) and for drinking, as well as in liquid.
Purpose of supplementation and type of collagen: type I collagen has more of an effect on hair, skin and nails, type 2 collagen on joints, and III is important for tissue regeneration.
Origin: decide whether you prefer fish collagen (sea collagen), beef, pork or maybe poultry.
Form: there are many options to choose from, including collagen powder and sachets, drinkable collagen, collagen in tablets or capsules or collagen in liquid.
Position: it is relevant whether you are taking natural collagen, collagen hydrolysate, or freeze-dried collagen; whether it is powdered animal cartilage or, however, biologically bioactive peptides - it all matters for the bioavailability of collagen.
Additional active ingredients: collagen supplements should contain vitamin C (supports natural collagen production and synthesis). In addition, look for ingredients such as hyaluronic acid, coenzyme Q10, field horsetail extract, biotin, zinc, copper, vitamin A, manganese and omega-3 acids or MSM. Here you will see the full criteria.

When choosing collagen, pay attention to whether it is hydrolysate or native collagen (natural). When you are faced with this dilemma, remember that it is best to choose hydrolysed fish collagen. Collagen peptides are smaller than normal collagen particles, making them better absorbed and more effective, and fish collagen is most similar to human collagen, which also makes it less allergenic.

Hydrolysed collagen peptides have a mass of only 3-6 kDa, while native collagen is typically 285-300 kDa.

Ilona Krzak Master of Pharmacy

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Where is type 3 collagen found?

Collagen type 3 is a protein that is found in many parts of the body. It can be found in the skin, lungs, blood vessels, myometrium, and in fetal tissuesand.

Mutation of the COL3A1 gene causes the vascular type of Ehlers-Danlos syndrome. Large arteries rupture and lead to sudden death in the patient.

Ilona Krzak Master of Pharmacy

You will also find it in muscle and bone marrow. What's more, it is also present in the extracellular matrix of some cancersand.

This type of collagen is found in smooth-cell myxomas or in malignant tumours: myxosarcoma, smooth-cell myxoma or fibrosarcoma.

Ilona Krzak Master of Pharmacy

Type III collagen belongs to a group of proteins called fibrillar collagens with interrupted triple helices (FACIT).

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What is type III collagen responsible for?

Although type III collagen is the second most common type of collagen in the body, its contribution to the physiological maintenance and repair of skeletal tissues is yet to be fully exploredand.

Type III collagen in bones was only discovered in 1991. Prior to that, it was thought to simply not be there.

Ilona Krzak Master of Pharmacy

Type III collagen works together with type I collagen and. Together, they provide structural support and maintain tissue integrity in the body. The combination of type 1 and type 3 collagen fibres gives elasticity to tissues.

The uterus enlarges more than 100 times during pregnancy

Ilona Krzak Master of Pharmacy

Type III collagen is particularly important for wound healing and tissue regeneration - it also helps in the formation of new blood vessels and collagen fibres, as well as platelet aggregationand.

During collagen remodelling, type II collagen is replaced by type I collagen to restore the normal collagen composition of the skin .

In addition, type III collagen is involved in the formation of the basement membrane, which has a protective function for tissues and organs , and also interacts with platelets in the clotting process .

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What is the difference between collagen types 1, 2 and 3?

The major types of collagen differ primarily in their structure and structure (primarily the number of alpha-1 and alpha-2 chains - that's enough for you now) and where they are found in the bodyand.

Type I collagen is the most abundant type of collagen in the body - making up as much as 90% of all collagen. It is found in skin, bones, tendons and ligamentsand.

Type II collagen is the main component of joint cartilage. It is also found in the auricle, nasal septum and intervertebral discs.

Type III collagen is present in skin, lungs, blood vessels, uterus and fetal tissues, among others. Type 3 collagen regulates type 1 collagen fibres and can also be found in reticular fibres, such as bone marrowand.

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Summary

Collagen type 3 is - after collagen type I - the second most common collagen in the human body.
It is present in many tissues of the body, including the skin, muscles, blood vessels or lungs, as well as in the tissues of the foetus.
Collagen type III is the most common type of collagen in the human body.
Type III collagen strengthens and ensures tissue integrity, promotes tissue regeneration and wound healing, and helps build blood vessels.
Collagen type III and type I fibres combine to give elasticity to tissues in the body.
Collagen supplements have a combination of type I and type III collagen in their formulation.
Collagen supplements have a combination of type I and type III collagen in their formulation.

FAQ

How many types of collagen are there?

Today there are said to be nearly 30 types of collagen - 28 to be exact. From your health and beauty perspective, the most important are type I, type II, type III and X.

For more interesting facts and benefits of collagen, see: 47 facts about the properties of collagen.

What kind of collagen for the skin?

The most important for skin is type I collagen. To improve its condition, radiance, firmness or colour a better solution than cosmetics and creams will be collagen supplements. The collagen molecules used in creams are usually too large to reach the dermis. In this form, they may help to moisturise it, but the effect will not be long-lasting. If you want long-lasting results, work from within.

Check out what is the best collagen for the skin.

What is the best collagen in tablets?

Choosing collagen tablets is difficult as new products are constantly appearing. Before buying, pay attention to the collagen content per dose, the origin and form of the collagen in question. Consider that there are also options in sachets, ampoules and shots if you want to conveniently take collagen on the go.

Are collagen and gelatine the same thing?

Collagen and gelatine are two different substances, but they have a few things in common. Gelatin is a product that is obtained from collagen by boiling and evaporating water.

Collagen is used in cosmetics, medicine and for supplementation. Gelatine is primarily used in the catering and food industry. Your favourite jellies have a lot of gelatine, but for health purposes and to supplement collagen deficiency, choosecollagen supplements.

Is collagen well absorbed?

Collagen bioavailability depends mainly on the source and how it is produced.

The best absorbed collagen is hydrolysed fish-derived collagen in the form of small peptides. Fish collagen (sea collagen) is absorbed up to 50% better than beef collagen.

What are collagen peptides?

Collagen peptides are short chains of amino acids, small collagen molecules that are formed during the process of collagen hydrolysis. The smaller the molecules, the more easily collagen is absorbed. Therefore, for supplementation choose products with collagen peptides.

Is vitamin K involved in collagen synthesis?

Vitamin K plays an important role in collagen synthesis. It is essential for the modification and activation of collagen-forming proteins. Without sufficient vitamin K, collagen may not be fully functional and unable to maintain proper structure.

Also important for the natural production of collagen is vitamin C.

Which fish collagen to choose?

When choosing fish collagen (sea collagen), pay attention to its dose per serving, as well as its origin and method of production. Check if the manufacturer uses patented ingredients or states where the raw material comes from and how the collagen is sourced.

What meat has the most collagen?

Based on the available literature, it is difficult to say unequivocally which meat has the most collagen. Its amount will vary depending on the type of meat and where the cut in question comes from. Some studies show that high amounts of collagen are contained in beef tendon, cod and eel skin or shark tail, among others. It has also been found that the content, bioavailability and properties of collagen also decrease with cooling.

Products (and foods) rich in collagen are primarily meat jellies, fruit jellies, offal, broth or chicken feet and fish - the latter also being a rich source of omega-3 acids.

Will I get collagen as a medicine?

No, there is no collagen on the market with drug status - you can buy collagen supplements in both pharmacies and drugstores. Remember to choose a particular product primarily based on the collagen content, its origin, form, form and additional active ingredients.

Sources

See all

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Archile-Contreras, A. C., Cha, M. C., Mandell, I. B., Miller, S. P., & Purslow, P. P. (2011). Vitamins E and C May Increase Collagen Turnover by Intramuscular Fibroblasts. Potential for Improved Meat Quality. Journal of Agricultural and Food Chemistry, 59(2), 608-614. https://doi.org/10.1021/jf103696t

Asai, T., Takahashi, A., Ito, K., Uetake, T., Matsumura, Y., Ikeda, K., Inagaki, N., Nakata, M., Imanishi, Y., & Sato, K. (2019). Amount of Collagen in the Meat Contained in Japanese Daily Dishes and the Collagen Peptide Content in Human Blood after Ingestion of Cooked Fish Meat. Journal of Agricultural and Food Chemistry, 67(10), 2831-2838. https://doi.org/10.1021/acs.jafc.8b06896

Eble, J. A., Kassner, A., Niland, S., Mörgelin, M., Grifka, J., & Grässel, S. (2006). Collagen XVI Harbors an Integrin α1β1 Recognition Site in Its C-terminal Domains *. Journal of Biological Chemistry, 281(35), 25745-25756. https://doi.org/10.1074/jbc.M509942200

Effect of refrigeration on the collagen and texture characteristics of yak meat. (n.d.). Retrieved 25 May 2023, from https://cdnsciencepub.com/doi/10.1139/cjas-2021-0059

Ichikawa, T., Horie-Inoue, K., Ikeda, K., Blumberg, B., & Inoue, S. (2006). Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells *♦. Journal of Biological Chemistry, 281(25), 16927-16934. https://doi.org/10.1074/jbc.M600896200

Kuivaniemi, H., & Tromp, G. (2019). Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene, 707, 151-171. https://doi.org/10.1016/j.gene.2019.05.003

Liu, X., Wu, H., Byrne, M., Krane, S., & Jaenisch, R. (1997). Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proceedings of the National Academy of Sciences, 94(5), 1852-1856. https://doi.org/10.1073/pnas.94.5.1852

Rørtveit, R., Reiten, M. R., Lingaas, F., Sveri, S. B., Brech, A., Espenes, A., & Jansen, J. H. (2015). Glomerular Collagen V Codeposition and Hepatic Perisinusoidal Collagen III Accumulation in Canine Collagen Type III Glomerulopathy. Veterinary Pathology, 52(6), 1134-1141. https://doi.org/10.1177/0300985814560237

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Stanchev, S., Stamenov, N., Kirkov, V., Dzhambazova, E., Nikolov, D., & Paloff, A. (2020). Differential collagen expression in kidney and heart during hypertension. Bratislavske Lekarske Listy, 121(1), 73-78. https://doi.org/10.4149/BLL_2020_011

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